TCF7L1 Accelerates Smooth Muscle Cell Phenotypic Switching and Aggravates Abdominal Aortic Aneurysms

Phenotypic switching of vascular smooth muscle cells is a central process in abdominal aortic aneurysm (AAA) pathology. We found that knockdown TCF7L1 (transcription factor 7-like 1), a member of the TCF/LEF (T cell factor/lymphoid enhancer factor) family of transcription factors, inhibits vascular...

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Detalles Bibliográficos
Autores principales: Wang, Jing, Tian, Xiaoxiang, Yan, Chenghui, Wu, Hanlin, Bu, Yuxin, Li, Jia, Liu, Dan, Han, Yaling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Research - Preclinical
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998605/
https://www.ncbi.nlm.nih.gov/pubmed/36908661
http://dx.doi.org/10.1016/j.jacbts.2022.07.012
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author Wang, Jing
Tian, Xiaoxiang
Yan, Chenghui
Wu, Hanlin
Bu, Yuxin
Li, Jia
Liu, Dan
Han, Yaling
author_facet Wang, Jing
Tian, Xiaoxiang
Yan, Chenghui
Wu, Hanlin
Bu, Yuxin
Li, Jia
Liu, Dan
Han, Yaling
author_sort Wang, Jing
collection PubMed
description Phenotypic switching of vascular smooth muscle cells is a central process in abdominal aortic aneurysm (AAA) pathology. We found that knockdown TCF7L1 (transcription factor 7-like 1), a member of the TCF/LEF (T cell factor/lymphoid enhancer factor) family of transcription factors, inhibits vascular smooth muscle cell differentiation. This study hints at potential interventions to maintain a normal, differentiated smooth muscle cell state, thereby eliminating the pathogenesis of AAA. In addition, our study provides insights into the potential use of TCF7L1 as a biomarker for AAA.
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spelling pubmed-99986052023-03-11 TCF7L1 Accelerates Smooth Muscle Cell Phenotypic Switching and Aggravates Abdominal Aortic Aneurysms Wang, Jing Tian, Xiaoxiang Yan, Chenghui Wu, Hanlin Bu, Yuxin Li, Jia Liu, Dan Han, Yaling JACC Basic Transl Sci Original Research - Preclinical Phenotypic switching of vascular smooth muscle cells is a central process in abdominal aortic aneurysm (AAA) pathology. We found that knockdown TCF7L1 (transcription factor 7-like 1), a member of the TCF/LEF (T cell factor/lymphoid enhancer factor) family of transcription factors, inhibits vascular smooth muscle cell differentiation. This study hints at potential interventions to maintain a normal, differentiated smooth muscle cell state, thereby eliminating the pathogenesis of AAA. In addition, our study provides insights into the potential use of TCF7L1 as a biomarker for AAA. Elsevier 2022-11-30 /pmc/articles/PMC9998605/ /pubmed/36908661 http://dx.doi.org/10.1016/j.jacbts.2022.07.012 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Research - Preclinical
Wang, Jing
Tian, Xiaoxiang
Yan, Chenghui
Wu, Hanlin
Bu, Yuxin
Li, Jia
Liu, Dan
Han, Yaling
TCF7L1 Accelerates Smooth Muscle Cell Phenotypic Switching and Aggravates Abdominal Aortic Aneurysms
title TCF7L1 Accelerates Smooth Muscle Cell Phenotypic Switching and Aggravates Abdominal Aortic Aneurysms
title_full TCF7L1 Accelerates Smooth Muscle Cell Phenotypic Switching and Aggravates Abdominal Aortic Aneurysms
title_fullStr TCF7L1 Accelerates Smooth Muscle Cell Phenotypic Switching and Aggravates Abdominal Aortic Aneurysms
title_full_unstemmed TCF7L1 Accelerates Smooth Muscle Cell Phenotypic Switching and Aggravates Abdominal Aortic Aneurysms
title_short TCF7L1 Accelerates Smooth Muscle Cell Phenotypic Switching and Aggravates Abdominal Aortic Aneurysms
title_sort tcf7l1 accelerates smooth muscle cell phenotypic switching and aggravates abdominal aortic aneurysms
topic Original Research - Preclinical
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998605/
https://www.ncbi.nlm.nih.gov/pubmed/36908661
http://dx.doi.org/10.1016/j.jacbts.2022.07.012
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