Sustained overexpression of spliced X-box-binding protein-1 in neurons leads to spontaneous seizures and sudden death in mice

The underlying etiologies of seizures are highly heterogeneous and remain incompletely understood. While studying the unfolded protein response (UPR) pathways in the brain, we unexpectedly discovered that transgenic mice (XBP1s-TG) expressing spliced X-box–binding protein-1 (Xbp1s), a key effector o...

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Detalles Bibliográficos
Autores principales: Wang, Zhuoran, Li, Qiang, Kolls, Brad J., Mace, Brian, Yu, Shu, Li, Xuan, Liu, Wei, Chaparro, Eduardo, Shen, Yuntian, Dang, Lihong, del Águila, Ángela, Bernstock, Joshua D., Johnson, Kory R., Yao, Junjie, Wetsel, William C., Moore, Scott D., Turner, Dennis A., Yang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998612/
https://www.ncbi.nlm.nih.gov/pubmed/36894627
http://dx.doi.org/10.1038/s42003-023-04594-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998612/
https://www.ncbi.nlm.nih.gov/pubmed/36894627
http://dx.doi.org/10.1038/s42003-023-04594-8

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