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Environmental effects on brain functional networks in a juvenile twin population
The brain’s intrinsic organization into large-scale functional networks, the resting state networks (RSN), shows complex inter-individual variability, consolidated during development. Nevertheless, the role of gene and environment on developmental brain functional connectivity (FC) remains largely u...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998648/ https://www.ncbi.nlm.nih.gov/pubmed/36894644 http://dx.doi.org/10.1038/s41598-023-30672-2 |
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author | Tassi, Emma Maggioni, Eleonora Mauri, Maddalena Fagnani, Corrado Agarwal, Nivedita Bianchi, Anna Maria Stazi, Maria A. Nobile, Maria Brambilla, Paolo |
author_facet | Tassi, Emma Maggioni, Eleonora Mauri, Maddalena Fagnani, Corrado Agarwal, Nivedita Bianchi, Anna Maria Stazi, Maria A. Nobile, Maria Brambilla, Paolo |
author_sort | Tassi, Emma |
collection | PubMed |
description | The brain’s intrinsic organization into large-scale functional networks, the resting state networks (RSN), shows complex inter-individual variability, consolidated during development. Nevertheless, the role of gene and environment on developmental brain functional connectivity (FC) remains largely unknown. Twin design represents an optimal platform to shed light on these effects acting on RSN characteristics. In this study, we applied statistical twin methods to resting-state functional magnetic resonance imaging (rs-fMRI) scans from 50 young twin pairs (aged 10–30 years) to preliminarily explore developmental determinants of brain FC. Multi-scale FC features were extracted and tested for applicability of classical ACE and ADE twin designs. Epistatic genetic effects were also assessed. In our sample, genetic and environmental effects on the brain functional connections largely varied between brain regions and FC features, showing good consistency at multiple spatial scales. Although we found selective contributions of common environment on temporo-occipital connections and of genetics on frontotemporal connections, the unique environment showed a predominant effect on FC link- and node-level features. Despite the lack of accurate genetic modeling, our preliminary results showed complex relationships between genes, environment, and functional brain connections during development. A predominant role of the unique environment on multi-scale RSN characteristics was suggested, which needs replications on independent samples. Future investigations should especially focus on nonadditive genetic effects, which remain largely unexplored. |
format | Online Article Text |
id | pubmed-9998648 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-99986482023-03-11 Environmental effects on brain functional networks in a juvenile twin population Tassi, Emma Maggioni, Eleonora Mauri, Maddalena Fagnani, Corrado Agarwal, Nivedita Bianchi, Anna Maria Stazi, Maria A. Nobile, Maria Brambilla, Paolo Sci Rep Article The brain’s intrinsic organization into large-scale functional networks, the resting state networks (RSN), shows complex inter-individual variability, consolidated during development. Nevertheless, the role of gene and environment on developmental brain functional connectivity (FC) remains largely unknown. Twin design represents an optimal platform to shed light on these effects acting on RSN characteristics. In this study, we applied statistical twin methods to resting-state functional magnetic resonance imaging (rs-fMRI) scans from 50 young twin pairs (aged 10–30 years) to preliminarily explore developmental determinants of brain FC. Multi-scale FC features were extracted and tested for applicability of classical ACE and ADE twin designs. Epistatic genetic effects were also assessed. In our sample, genetic and environmental effects on the brain functional connections largely varied between brain regions and FC features, showing good consistency at multiple spatial scales. Although we found selective contributions of common environment on temporo-occipital connections and of genetics on frontotemporal connections, the unique environment showed a predominant effect on FC link- and node-level features. Despite the lack of accurate genetic modeling, our preliminary results showed complex relationships between genes, environment, and functional brain connections during development. A predominant role of the unique environment on multi-scale RSN characteristics was suggested, which needs replications on independent samples. Future investigations should especially focus on nonadditive genetic effects, which remain largely unexplored. Nature Publishing Group UK 2023-03-09 /pmc/articles/PMC9998648/ /pubmed/36894644 http://dx.doi.org/10.1038/s41598-023-30672-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Tassi, Emma Maggioni, Eleonora Mauri, Maddalena Fagnani, Corrado Agarwal, Nivedita Bianchi, Anna Maria Stazi, Maria A. Nobile, Maria Brambilla, Paolo Environmental effects on brain functional networks in a juvenile twin population |
title | Environmental effects on brain functional networks in a juvenile twin population |
title_full | Environmental effects on brain functional networks in a juvenile twin population |
title_fullStr | Environmental effects on brain functional networks in a juvenile twin population |
title_full_unstemmed | Environmental effects on brain functional networks in a juvenile twin population |
title_short | Environmental effects on brain functional networks in a juvenile twin population |
title_sort | environmental effects on brain functional networks in a juvenile twin population |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998648/ https://www.ncbi.nlm.nih.gov/pubmed/36894644 http://dx.doi.org/10.1038/s41598-023-30672-2 |
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