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Myalgic Encephalomyelitis/Chronic Fatigue Syndrome is common in post-acute sequelae of SARS-CoV-2 infection (PASC): Results from a post-COVID-19 multidisciplinary clinic

BACKGROUND: The global prevalence of PASC is estimated to be present in 0·43 and based on the WHO estimation of 470 million worldwide COVID-19 infections, corresponds to around 200 million people experiencing long COVID symptoms. Despite this, its clinical features are not well-defined. METHODS: We...

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Detalles Bibliográficos
Autores principales: Bonilla, Hector, Quach, Tom C., Tiwari, Anushri, Bonilla, Andres E., Miglis, Mitchell, Yang, Phillip C., Eggert, Lauren E., Sharifi, Husham, Horomanski, Audra, Subramanian, Aruna, Smirnoff, Liza, Simpson, Norah, Halawi, Houssan, Sum-ping, Oliver, Kalinowski, Agnieszka, Patel, Zara M., Shafer, Robert William, Geng, Linda N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998690/
https://www.ncbi.nlm.nih.gov/pubmed/36908615
http://dx.doi.org/10.3389/fneur.2023.1090747
Descripción
Sumario:BACKGROUND: The global prevalence of PASC is estimated to be present in 0·43 and based on the WHO estimation of 470 million worldwide COVID-19 infections, corresponds to around 200 million people experiencing long COVID symptoms. Despite this, its clinical features are not well-defined. METHODS: We collected retrospective data from 140 patients with PASC in a post-COVID-19 clinic on demographics, risk factors, illness severity (graded as one-mild to five-severe), functional status, and 29 symptoms and principal component symptoms cluster analysis. The Institute of Medicine (IOM) 2015 criteria were used to determine the Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) phenotype. FINDINGS: The median age was 47 years, 59.0% were female; 49.3% White, 17.2% Hispanic, 14.9% Asian, and 6.7% Black. Only 12.7% required hospitalization. Seventy-two (53.5%) patients had no known comorbid conditions. Forty-five (33.9%) were significantly debilitated. The median duration of symptoms was 285.5 days, and the number of symptoms was 12. The most common symptoms were fatigue (86.5%), post-exertional malaise (82.8%), brain fog (81.2%), unrefreshing sleep (76.7%), and lethargy (74.6%). Forty-three percent fit the criteria for ME/CFS, majority were female, and obesity (BMI > 30 Kg/m(2)) (P = 0.00377895) and worse functional status (P = 0.0110474) were significantly associated with ME/CFS. INTERPRETATIONS: Most PASC patients evaluated at our clinic had no comorbid condition and were not hospitalized for acute COVID-19. One-third of patients experienced a severe decline in their functional status. About 43% had the ME/CFS subtype.