Regulation of SUMOylation on RNA metabolism in cancers

Post-translational modifications of proteins play very important roles in regulating RNA metabolism and affect many biological pathways. Here we mainly summarize the crucial functions of small ubiquitin-like modifier (SUMO) modification in RNA metabolism including transcription, splicing, tailing, s...

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Autores principales: Cao, Yingting, Huang, Caihu, Zhao, Xian, Yu, Jianxiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998694/
https://www.ncbi.nlm.nih.gov/pubmed/36911524
http://dx.doi.org/10.3389/fmolb.2023.1137215
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author Cao, Yingting
Huang, Caihu
Zhao, Xian
Yu, Jianxiu
author_facet Cao, Yingting
Huang, Caihu
Zhao, Xian
Yu, Jianxiu
author_sort Cao, Yingting
collection PubMed
description Post-translational modifications of proteins play very important roles in regulating RNA metabolism and affect many biological pathways. Here we mainly summarize the crucial functions of small ubiquitin-like modifier (SUMO) modification in RNA metabolism including transcription, splicing, tailing, stability and modification, as well as its impact on the biogenesis and function of microRNA (miRNA) in particular. This review also highlights the current knowledge about SUMOylation regulation in RNA metabolism involved in many cellular processes such as cell proliferation and apoptosis, which is closely related to tumorigenesis and cancer progression.
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spelling pubmed-99986942023-03-11 Regulation of SUMOylation on RNA metabolism in cancers Cao, Yingting Huang, Caihu Zhao, Xian Yu, Jianxiu Front Mol Biosci Molecular Biosciences Post-translational modifications of proteins play very important roles in regulating RNA metabolism and affect many biological pathways. Here we mainly summarize the crucial functions of small ubiquitin-like modifier (SUMO) modification in RNA metabolism including transcription, splicing, tailing, stability and modification, as well as its impact on the biogenesis and function of microRNA (miRNA) in particular. This review also highlights the current knowledge about SUMOylation regulation in RNA metabolism involved in many cellular processes such as cell proliferation and apoptosis, which is closely related to tumorigenesis and cancer progression. Frontiers Media S.A. 2023-02-24 /pmc/articles/PMC9998694/ /pubmed/36911524 http://dx.doi.org/10.3389/fmolb.2023.1137215 Text en Copyright © 2023 Cao, Huang, Zhao and Yu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Cao, Yingting
Huang, Caihu
Zhao, Xian
Yu, Jianxiu
Regulation of SUMOylation on RNA metabolism in cancers
title Regulation of SUMOylation on RNA metabolism in cancers
title_full Regulation of SUMOylation on RNA metabolism in cancers
title_fullStr Regulation of SUMOylation on RNA metabolism in cancers
title_full_unstemmed Regulation of SUMOylation on RNA metabolism in cancers
title_short Regulation of SUMOylation on RNA metabolism in cancers
title_sort regulation of sumoylation on rna metabolism in cancers
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998694/
https://www.ncbi.nlm.nih.gov/pubmed/36911524
http://dx.doi.org/10.3389/fmolb.2023.1137215
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AT huangcaihu regulationofsumoylationonrnametabolismincancers
AT zhaoxian regulationofsumoylationonrnametabolismincancers
AT yujianxiu regulationofsumoylationonrnametabolismincancers

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