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Gut microbiota dysbiosis in polycystic ovary syndrome: Mechanisms of progression and clinical applications

Polycystic ovary syndrome (PCOS) is the most common endocrine diseases in women of childbearing age that leads to menstrual disorders and infertility. The pathogenesis of PCOS is complex and has not yet been fully clarified. Gut microbiota is associated with disorders of lipid, glucose, and steroid...

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Autores principales: Sun, Yan, Gao, Shouyang, Ye, Cong, Zhao, Weiliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998696/
https://www.ncbi.nlm.nih.gov/pubmed/36909735
http://dx.doi.org/10.3389/fcimb.2023.1142041
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author Sun, Yan
Gao, Shouyang
Ye, Cong
Zhao, Weiliang
author_facet Sun, Yan
Gao, Shouyang
Ye, Cong
Zhao, Weiliang
author_sort Sun, Yan
collection PubMed
description Polycystic ovary syndrome (PCOS) is the most common endocrine diseases in women of childbearing age that leads to menstrual disorders and infertility. The pathogenesis of PCOS is complex and has not yet been fully clarified. Gut microbiota is associated with disorders of lipid, glucose, and steroid hormone metabolish. A large body of studies demonstrated that gut microbiota could regulate the synthesis and secretion of insulin, and affect androgen metabolism and follicle development, providing us a novel idea for unravelling the pathogenesis of PCOS. The relationship between gut microbiota and the pathogenesis of PCOS is particularly important. This study reviewed recent research advances in the roles of gut microbiota in the occurrence and development of PCOS. It is expected to provide a new direction for the treatment of PCOS based on gut microbiota.
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spelling pubmed-99986962023-03-11 Gut microbiota dysbiosis in polycystic ovary syndrome: Mechanisms of progression and clinical applications Sun, Yan Gao, Shouyang Ye, Cong Zhao, Weiliang Front Cell Infect Microbiol Cellular and Infection Microbiology Polycystic ovary syndrome (PCOS) is the most common endocrine diseases in women of childbearing age that leads to menstrual disorders and infertility. The pathogenesis of PCOS is complex and has not yet been fully clarified. Gut microbiota is associated with disorders of lipid, glucose, and steroid hormone metabolish. A large body of studies demonstrated that gut microbiota could regulate the synthesis and secretion of insulin, and affect androgen metabolism and follicle development, providing us a novel idea for unravelling the pathogenesis of PCOS. The relationship between gut microbiota and the pathogenesis of PCOS is particularly important. This study reviewed recent research advances in the roles of gut microbiota in the occurrence and development of PCOS. It is expected to provide a new direction for the treatment of PCOS based on gut microbiota. Frontiers Media S.A. 2023-02-24 /pmc/articles/PMC9998696/ /pubmed/36909735 http://dx.doi.org/10.3389/fcimb.2023.1142041 Text en Copyright © 2023 Sun, Gao, Ye and Zhao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Sun, Yan
Gao, Shouyang
Ye, Cong
Zhao, Weiliang
Gut microbiota dysbiosis in polycystic ovary syndrome: Mechanisms of progression and clinical applications
title Gut microbiota dysbiosis in polycystic ovary syndrome: Mechanisms of progression and clinical applications
title_full Gut microbiota dysbiosis in polycystic ovary syndrome: Mechanisms of progression and clinical applications
title_fullStr Gut microbiota dysbiosis in polycystic ovary syndrome: Mechanisms of progression and clinical applications
title_full_unstemmed Gut microbiota dysbiosis in polycystic ovary syndrome: Mechanisms of progression and clinical applications
title_short Gut microbiota dysbiosis in polycystic ovary syndrome: Mechanisms of progression and clinical applications
title_sort gut microbiota dysbiosis in polycystic ovary syndrome: mechanisms of progression and clinical applications
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998696/
https://www.ncbi.nlm.nih.gov/pubmed/36909735
http://dx.doi.org/10.3389/fcimb.2023.1142041
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