Anti-Kv1.4 Antibody Without Myasthenia Gravis: A Rare Cause of Autoimmune Myocarditis and Myositis

Anti-Kv1.4 antibody is often detected in thymoma-associated myasthenia gravis patients with anti-acetylcholine receptor antibody. Herein, we describe 2 patients with concurrent myocarditis and myositis. In both cases, anti-Kv1.4 antibody was positive despite the absence of thymoma and anti-acetylcho...

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Autores principales: Kuyama, Naoto, Takashio, Seiji, Nagakura, Takumi, Imamura, Michie, Takamatsu, Koutaro, Takae, Masafumi, Hirakawa, Kyoko, Yamanaga, Kenshi, Hanatani, Shinsuke, Yamamoto, Eiichiro, Matsushita, Kenichi, Ueda, Mitsuharu, Tsujita, Kenichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998724/
https://www.ncbi.nlm.nih.gov/pubmed/36909266
http://dx.doi.org/10.1016/j.jaccas.2023.101734
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author Kuyama, Naoto
Takashio, Seiji
Nagakura, Takumi
Imamura, Michie
Takamatsu, Koutaro
Takae, Masafumi
Hirakawa, Kyoko
Yamanaga, Kenshi
Hanatani, Shinsuke
Yamamoto, Eiichiro
Matsushita, Kenichi
Ueda, Mitsuharu
Tsujita, Kenichi
author_facet Kuyama, Naoto
Takashio, Seiji
Nagakura, Takumi
Imamura, Michie
Takamatsu, Koutaro
Takae, Masafumi
Hirakawa, Kyoko
Yamanaga, Kenshi
Hanatani, Shinsuke
Yamamoto, Eiichiro
Matsushita, Kenichi
Ueda, Mitsuharu
Tsujita, Kenichi
author_sort Kuyama, Naoto
collection PubMed
description Anti-Kv1.4 antibody is often detected in thymoma-associated myasthenia gravis patients with anti-acetylcholine receptor antibody. Herein, we describe 2 patients with concurrent myocarditis and myositis. In both cases, anti-Kv1.4 antibody was positive despite the absence of thymoma and anti-acetylcholine receptor antibody, and immunosuppressants eventually resolved their symptoms and cardiac function. (Level of Difficulty: Advanced.)
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spelling pubmed-99987242023-03-11 Anti-Kv1.4 Antibody Without Myasthenia Gravis: A Rare Cause of Autoimmune Myocarditis and Myositis Kuyama, Naoto Takashio, Seiji Nagakura, Takumi Imamura, Michie Takamatsu, Koutaro Takae, Masafumi Hirakawa, Kyoko Yamanaga, Kenshi Hanatani, Shinsuke Yamamoto, Eiichiro Matsushita, Kenichi Ueda, Mitsuharu Tsujita, Kenichi JACC Case Rep Case Report Anti-Kv1.4 antibody is often detected in thymoma-associated myasthenia gravis patients with anti-acetylcholine receptor antibody. Herein, we describe 2 patients with concurrent myocarditis and myositis. In both cases, anti-Kv1.4 antibody was positive despite the absence of thymoma and anti-acetylcholine receptor antibody, and immunosuppressants eventually resolved their symptoms and cardiac function. (Level of Difficulty: Advanced.) Elsevier 2023-01-27 /pmc/articles/PMC9998724/ /pubmed/36909266 http://dx.doi.org/10.1016/j.jaccas.2023.101734 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kuyama, Naoto
Takashio, Seiji
Nagakura, Takumi
Imamura, Michie
Takamatsu, Koutaro
Takae, Masafumi
Hirakawa, Kyoko
Yamanaga, Kenshi
Hanatani, Shinsuke
Yamamoto, Eiichiro
Matsushita, Kenichi
Ueda, Mitsuharu
Tsujita, Kenichi
Anti-Kv1.4 Antibody Without Myasthenia Gravis: A Rare Cause of Autoimmune Myocarditis and Myositis
title Anti-Kv1.4 Antibody Without Myasthenia Gravis: A Rare Cause of Autoimmune Myocarditis and Myositis
title_full Anti-Kv1.4 Antibody Without Myasthenia Gravis: A Rare Cause of Autoimmune Myocarditis and Myositis
title_fullStr Anti-Kv1.4 Antibody Without Myasthenia Gravis: A Rare Cause of Autoimmune Myocarditis and Myositis
title_full_unstemmed Anti-Kv1.4 Antibody Without Myasthenia Gravis: A Rare Cause of Autoimmune Myocarditis and Myositis
title_short Anti-Kv1.4 Antibody Without Myasthenia Gravis: A Rare Cause of Autoimmune Myocarditis and Myositis
title_sort anti-kv1.4 antibody without myasthenia gravis: a rare cause of autoimmune myocarditis and myositis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998724/
https://www.ncbi.nlm.nih.gov/pubmed/36909266
http://dx.doi.org/10.1016/j.jaccas.2023.101734
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