Mechanisms of the “No-Reflow” Phenomenon After Acute Myocardial Infarction: Potential Role of Pericytes

Pericytes contract during myocardial ischemia resulting in capillary constriction and no reflow. Reversing pericyte contraction pharmacologically reduces no reflow and infarct size. These findings open up an entire new venue of research aimed at altering pericyte function in myocardial ischemia and...

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Detalles Bibliográficos
Autores principales: Kaul, Sanjiv, Methner, Carmen, Cao, Zhiping, Mishra, Anusha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
State-of-the-Art Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998747/
https://www.ncbi.nlm.nih.gov/pubmed/36908667
http://dx.doi.org/10.1016/j.jacbts.2022.06.008
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author Kaul, Sanjiv
Methner, Carmen
Cao, Zhiping
Mishra, Anusha
author_facet Kaul, Sanjiv
Methner, Carmen
Cao, Zhiping
Mishra, Anusha
author_sort Kaul, Sanjiv
collection PubMed
description Pericytes contract during myocardial ischemia resulting in capillary constriction and no reflow. Reversing pericyte contraction pharmacologically reduces no reflow and infarct size. These findings open up an entire new venue of research aimed at altering pericyte function in myocardial ischemia and infarction.
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spelling pubmed-99987472023-03-11 Mechanisms of the “No-Reflow” Phenomenon After Acute Myocardial Infarction: Potential Role of Pericytes Kaul, Sanjiv Methner, Carmen Cao, Zhiping Mishra, Anusha JACC Basic Transl Sci State-of-the-Art Review Pericytes contract during myocardial ischemia resulting in capillary constriction and no reflow. Reversing pericyte contraction pharmacologically reduces no reflow and infarct size. These findings open up an entire new venue of research aimed at altering pericyte function in myocardial ischemia and infarction. Elsevier 2022-09-21 /pmc/articles/PMC9998747/ /pubmed/36908667 http://dx.doi.org/10.1016/j.jacbts.2022.06.008 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle State-of-the-Art Review
Kaul, Sanjiv
Methner, Carmen
Cao, Zhiping
Mishra, Anusha
Mechanisms of the “No-Reflow” Phenomenon After Acute Myocardial Infarction: Potential Role of Pericytes
title Mechanisms of the “No-Reflow” Phenomenon After Acute Myocardial Infarction: Potential Role of Pericytes
title_full Mechanisms of the “No-Reflow” Phenomenon After Acute Myocardial Infarction: Potential Role of Pericytes
title_fullStr Mechanisms of the “No-Reflow” Phenomenon After Acute Myocardial Infarction: Potential Role of Pericytes
title_full_unstemmed Mechanisms of the “No-Reflow” Phenomenon After Acute Myocardial Infarction: Potential Role of Pericytes
title_short Mechanisms of the “No-Reflow” Phenomenon After Acute Myocardial Infarction: Potential Role of Pericytes
title_sort mechanisms of the “no-reflow” phenomenon after acute myocardial infarction: potential role of pericytes
topic State-of-the-Art Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998747/
https://www.ncbi.nlm.nih.gov/pubmed/36908667
http://dx.doi.org/10.1016/j.jacbts.2022.06.008
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