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Serum Copeptin in Cardiooncology Practice: Review of Pathophysiological and Clinical Implications

In cardiooncology practice, “early cardiotoxicity” refers to an emerging subclinical myocardial dysfunction/injury in response to certain chemotherapeutic regimens. This condition can progress to overt cardiotoxicity in time and hence warrants proper and timely diagnostic and preventive strategies....

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Detalles Bibliográficos
Autores principales: Yalta, Kenan, Yetkin, Ertan, Yalta, Tülin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998837/
https://www.ncbi.nlm.nih.gov/pubmed/36883738
http://dx.doi.org/10.4274/balkanmedj.galenos.2023.2023-2-14
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author Yalta, Kenan
Yetkin, Ertan
Yalta, Tülin
author_facet Yalta, Kenan
Yetkin, Ertan
Yalta, Tülin
author_sort Yalta, Kenan
collection PubMed
description In cardiooncology practice, “early cardiotoxicity” refers to an emerging subclinical myocardial dysfunction/injury in response to certain chemotherapeutic regimens. This condition can progress to overt cardiotoxicity in time and hence warrants proper and timely diagnostic and preventive strategies. Current diagnostic strategies for “early cardiotoxicity” are largely based on conventional biomarkers and certain echocardiographic indices. However, a significant gap still exists in this setting, warranting further strategies to improve diagnosis and overall prognosis in cancer survivors. Copeptin (surrogate marker of the arginine vasopressine axis) might serve as a promising adjunctive guide for the timely detection, risk stratification, and management of early cardiotoxicity on top of conventional strategies largely due to its multifaceted pathophysiological implications in the clinical setting. This work aims to focus on serum copeptin as a marker of “early cardiotoxicity” and its general clinical implications in patients with cancer.
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spelling pubmed-99988372023-03-11 Serum Copeptin in Cardiooncology Practice: Review of Pathophysiological and Clinical Implications Yalta, Kenan Yetkin, Ertan Yalta, Tülin Balkan Med J Invited Review In cardiooncology practice, “early cardiotoxicity” refers to an emerging subclinical myocardial dysfunction/injury in response to certain chemotherapeutic regimens. This condition can progress to overt cardiotoxicity in time and hence warrants proper and timely diagnostic and preventive strategies. Current diagnostic strategies for “early cardiotoxicity” are largely based on conventional biomarkers and certain echocardiographic indices. However, a significant gap still exists in this setting, warranting further strategies to improve diagnosis and overall prognosis in cancer survivors. Copeptin (surrogate marker of the arginine vasopressine axis) might serve as a promising adjunctive guide for the timely detection, risk stratification, and management of early cardiotoxicity on top of conventional strategies largely due to its multifaceted pathophysiological implications in the clinical setting. This work aims to focus on serum copeptin as a marker of “early cardiotoxicity” and its general clinical implications in patients with cancer. Galenos Publishing 2023-03-08 /pmc/articles/PMC9998837/ /pubmed/36883738 http://dx.doi.org/10.4274/balkanmedj.galenos.2023.2023-2-14 Text en ©Copyright 2023 by Trakya University Faculty of Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Balkan Medical Journal published by Galenos Publishing House.
spellingShingle Invited Review
Yalta, Kenan
Yetkin, Ertan
Yalta, Tülin
Serum Copeptin in Cardiooncology Practice: Review of Pathophysiological and Clinical Implications
title Serum Copeptin in Cardiooncology Practice: Review of Pathophysiological and Clinical Implications
title_full Serum Copeptin in Cardiooncology Practice: Review of Pathophysiological and Clinical Implications
title_fullStr Serum Copeptin in Cardiooncology Practice: Review of Pathophysiological and Clinical Implications
title_full_unstemmed Serum Copeptin in Cardiooncology Practice: Review of Pathophysiological and Clinical Implications
title_short Serum Copeptin in Cardiooncology Practice: Review of Pathophysiological and Clinical Implications
title_sort serum copeptin in cardiooncology practice: review of pathophysiological and clinical implications
topic Invited Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998837/
https://www.ncbi.nlm.nih.gov/pubmed/36883738
http://dx.doi.org/10.4274/balkanmedj.galenos.2023.2023-2-14
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