Fenretinide inhibits obesity and fatty liver disease but induces Smpd3 to increase serum ceramides and worsen atherosclerosis in LDLR(−/−) mice

Fenretinide is a synthetic retinoid that can prevent obesity and improve insulin sensitivity in mice by directly altering retinol/retinoic acid homeostasis and inhibiting excess ceramide biosynthesis. We determined the effects of Fenretinide on LDLR(−/−) mice fed high-fat/high-cholesterol diet ± Fen...

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Detalles Bibliográficos
Autores principales: Thompson, Dawn, Mahmood, Shehroz, Morrice, Nicola, Kamli-Salino, Sarah, Dekeryte, Ruta, Hoffmann, Philip A., Doherty, Mary K., Whitfield, Philip D., Delibegović, Mirela, Mody, Nimesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998859/
https://www.ncbi.nlm.nih.gov/pubmed/36894641
http://dx.doi.org/10.1038/s41598-023-30759-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998859/
https://www.ncbi.nlm.nih.gov/pubmed/36894641
http://dx.doi.org/10.1038/s41598-023-30759-w

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