The toxic natural product tutin causes epileptic seizures in mice by activating calcineurin

Tutin, an established toxic natural product that causes epilepsy in rodents, is often used as a tool to develop animal model of acute epileptic seizures. However, the molecular target and toxic mechanism of tutin were unclear. In this study, for the first time, we conducted experiments to clarify th...

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Detalles Bibliográficos
Autores principales: Han, Qing-Tong, Yang, Wan-Qi, Zang, Caixia, Zhou, Linchao, Zhang, Chong-Jing, Bao, Xiuqi, Cai, Jie, Li, Fangfei, Shi, Qinyan, Wang, Xiao-Liang, Qu, Jing, Zhang, Dan, Yu, Shi-Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998865/
https://www.ncbi.nlm.nih.gov/pubmed/36894540
http://dx.doi.org/10.1038/s41392-023-01312-y

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