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Establishment of ultrasound-responsive SonoBacteriaBot for targeted drug delivery and controlled release

Bacteria-driven biohybrid microbots have shown great potential in ca(n)cer treatment. However, how precisely controlling drug release at the tumor site is still an issue. To overcome the limitation of this system, we proposed the ultrasound-responsive SonoBacteriaBot (DOX-PFP-PLGA@EcM). Doxorubicin...

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Autores principales: Du, Meng, Wang, Ting, Feng, Renjie, Zeng, Penghui, Chen, Zhiyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998949/
https://www.ncbi.nlm.nih.gov/pubmed/36911192
http://dx.doi.org/10.3389/fbioe.2023.1144963
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author Du, Meng
Wang, Ting
Feng, Renjie
Zeng, Penghui
Chen, Zhiyi
author_facet Du, Meng
Wang, Ting
Feng, Renjie
Zeng, Penghui
Chen, Zhiyi
author_sort Du, Meng
collection PubMed
description Bacteria-driven biohybrid microbots have shown great potential in ca(n)cer treatment. However, how precisely controlling drug release at the tumor site is still an issue. To overcome the limitation of this system, we proposed the ultrasound-responsive SonoBacteriaBot (DOX-PFP-PLGA@EcM). Doxorubicin (DOX) and perfluoro-n-pentane (PFP) were encapsulated in polylactic acid-glycolic acid (PLGA) to form ultrasound-responsive DOX-PFP-PLGA nanodroplets. Then, DOX-PFP-PLGA@EcM is created by DOX-PFP-PLGA amide-bonded to the surface of E. coli MG1655 (EcM). The DOX-PFP-PLGA@EcM was proved to have the characteristics of high tumor-targeting efficiency, controlled drug release capability, and ultrasound imaging. Based on the acoustic phase change function of nanodroplets, DOX-PFP-PLGA@EcM enhance the signal of US imaging after ultrasound irradiation. Meanwhile, the DOX loaded into DOX-PFP-PLGA@EcM can be released. After being intravenously injected, DOX-PFP-PLGA@EcM can efficiently accumulate in tumors without causing harm to critical organs. In conclusion, the SonoBacteriaBot has significant benefits in real-time monitoring and controlled drug release, which has significant potential applications for therapeutic drug delivery in clinical settings.
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spelling pubmed-99989492023-03-11 Establishment of ultrasound-responsive SonoBacteriaBot for targeted drug delivery and controlled release Du, Meng Wang, Ting Feng, Renjie Zeng, Penghui Chen, Zhiyi Front Bioeng Biotechnol Bioengineering and Biotechnology Bacteria-driven biohybrid microbots have shown great potential in ca(n)cer treatment. However, how precisely controlling drug release at the tumor site is still an issue. To overcome the limitation of this system, we proposed the ultrasound-responsive SonoBacteriaBot (DOX-PFP-PLGA@EcM). Doxorubicin (DOX) and perfluoro-n-pentane (PFP) were encapsulated in polylactic acid-glycolic acid (PLGA) to form ultrasound-responsive DOX-PFP-PLGA nanodroplets. Then, DOX-PFP-PLGA@EcM is created by DOX-PFP-PLGA amide-bonded to the surface of E. coli MG1655 (EcM). The DOX-PFP-PLGA@EcM was proved to have the characteristics of high tumor-targeting efficiency, controlled drug release capability, and ultrasound imaging. Based on the acoustic phase change function of nanodroplets, DOX-PFP-PLGA@EcM enhance the signal of US imaging after ultrasound irradiation. Meanwhile, the DOX loaded into DOX-PFP-PLGA@EcM can be released. After being intravenously injected, DOX-PFP-PLGA@EcM can efficiently accumulate in tumors without causing harm to critical organs. In conclusion, the SonoBacteriaBot has significant benefits in real-time monitoring and controlled drug release, which has significant potential applications for therapeutic drug delivery in clinical settings. Frontiers Media S.A. 2023-02-24 /pmc/articles/PMC9998949/ /pubmed/36911192 http://dx.doi.org/10.3389/fbioe.2023.1144963 Text en Copyright © 2023 Du, Wang, Feng, Zeng and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Du, Meng
Wang, Ting
Feng, Renjie
Zeng, Penghui
Chen, Zhiyi
Establishment of ultrasound-responsive SonoBacteriaBot for targeted drug delivery and controlled release
title Establishment of ultrasound-responsive SonoBacteriaBot for targeted drug delivery and controlled release
title_full Establishment of ultrasound-responsive SonoBacteriaBot for targeted drug delivery and controlled release
title_fullStr Establishment of ultrasound-responsive SonoBacteriaBot for targeted drug delivery and controlled release
title_full_unstemmed Establishment of ultrasound-responsive SonoBacteriaBot for targeted drug delivery and controlled release
title_short Establishment of ultrasound-responsive SonoBacteriaBot for targeted drug delivery and controlled release
title_sort establishment of ultrasound-responsive sonobacteriabot for targeted drug delivery and controlled release
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998949/
https://www.ncbi.nlm.nih.gov/pubmed/36911192
http://dx.doi.org/10.3389/fbioe.2023.1144963
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