Antagonism between Prdm16 and Smad4 specifies the trajectory and progression of pancreatic cancer

The transcription factor Prdm16 functions as a potent suppressor of transforming growth factor-beta (TGF-β) signaling, whose inactivation is deemed essential to the progression of pancreatic ductal adenocarcinoma (PDAC). Using the KrasG12D-based mouse model of human PDAC, we surprisingly found that...

Descripción completa

Detalles Bibliográficos
Autores principales: Hurwitz, Eric, Parajuli, Parash, Ozkan, Seval, Prunier, Celine, Nguyen, Thien Ly, Campbell, Deanna, Friend, Creighton, Bryan, Allyn Austin, Lu, Ting-Xuan, Smith, Steven Christopher, Razzaque, Mohammed Shawkat, Xu, Keli, Atfi, Azeddine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999015/
https://www.ncbi.nlm.nih.gov/pubmed/36828547
http://dx.doi.org/10.1083/jcb.202203036

Ejemplares similares

Ejemplares similares