Candida keratitis and endopthalmitis after corneal transplantation; two case reports, a novel regimen and literature overview of therapeutic options

PURPOSE: To evaluate treatment options for candida keratitis and endopthalmitis after corneal transplantation. METHODS: Case reports and literature review. RESULTS: Two patients with keratitis due to Candida glabrata/parapsilosis after corneal transplantation were successfully treated with a combina...

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Autores principales: van der Wekken-Pas, LC, de Haas, PJ, Wisse, R, Rados, M, van der Elst, KCM
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999277/
https://www.ncbi.nlm.nih.gov/pubmed/34812090
http://dx.doi.org/10.1177/11206721211060140
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author van der Wekken-Pas, LC
de Haas, PJ
Wisse, R
Rados, M
van der Elst, KCM
author_facet van der Wekken-Pas, LC
de Haas, PJ
Wisse, R
Rados, M
van der Elst, KCM
author_sort van der Wekken-Pas, LC
collection PubMed
description PURPOSE: To evaluate treatment options for candida keratitis and endopthalmitis after corneal transplantation. METHODS: Case reports and literature review. RESULTS: Two patients with keratitis due to Candida glabrata/parapsilosis after corneal transplantation were successfully treated with a combination of topical voriconazole, intracameral voriconazole and amphotericin B, and systemic treatment with flucytosine. CONCLUSIONS: Natamycine and voriconazole topically are preferred therapeutic options for the treatment of fungal keratitis. Systemic flucytosine is a useful alternative additive, particularly for countries where natamycine is not registered as a pharmaceutical agent.
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spelling pubmed-99992772023-03-11 Candida keratitis and endopthalmitis after corneal transplantation; two case reports, a novel regimen and literature overview of therapeutic options van der Wekken-Pas, LC de Haas, PJ Wisse, R Rados, M van der Elst, KCM Eur J Ophthalmol Case Reports PURPOSE: To evaluate treatment options for candida keratitis and endopthalmitis after corneal transplantation. METHODS: Case reports and literature review. RESULTS: Two patients with keratitis due to Candida glabrata/parapsilosis after corneal transplantation were successfully treated with a combination of topical voriconazole, intracameral voriconazole and amphotericin B, and systemic treatment with flucytosine. CONCLUSIONS: Natamycine and voriconazole topically are preferred therapeutic options for the treatment of fungal keratitis. Systemic flucytosine is a useful alternative additive, particularly for countries where natamycine is not registered as a pharmaceutical agent. SAGE Publications 2021-11-23 2023-03 /pmc/articles/PMC9999277/ /pubmed/34812090 http://dx.doi.org/10.1177/11206721211060140 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Reports
van der Wekken-Pas, LC
de Haas, PJ
Wisse, R
Rados, M
van der Elst, KCM
Candida keratitis and endopthalmitis after corneal transplantation; two case reports, a novel regimen and literature overview of therapeutic options
title Candida keratitis and endopthalmitis after corneal transplantation; two case reports, a novel regimen and literature overview of therapeutic options
title_full Candida keratitis and endopthalmitis after corneal transplantation; two case reports, a novel regimen and literature overview of therapeutic options
title_fullStr Candida keratitis and endopthalmitis after corneal transplantation; two case reports, a novel regimen and literature overview of therapeutic options
title_full_unstemmed Candida keratitis and endopthalmitis after corneal transplantation; two case reports, a novel regimen and literature overview of therapeutic options
title_short Candida keratitis and endopthalmitis after corneal transplantation; two case reports, a novel regimen and literature overview of therapeutic options
title_sort candida keratitis and endopthalmitis after corneal transplantation; two case reports, a novel regimen and literature overview of therapeutic options
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999277/
https://www.ncbi.nlm.nih.gov/pubmed/34812090
http://dx.doi.org/10.1177/11206721211060140
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