Microneedle-based interstitial fluid extraction for drug analysis: Advances, challenges, and prospects
Similar to blood, interstitial fluid (ISF) contains exogenous drugs and biomarkers and may therefore substitute blood in drug analysis. However, current ISF extraction techniques require bulky instruments and are both time-consuming and complicated, which has inspired the development of viable alter...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Xi'an Jiaotong University
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999301/ https://www.ncbi.nlm.nih.gov/pubmed/36908860 http://dx.doi.org/10.1016/j.jpha.2022.12.004 |
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author | Ma, Shuwen Li, Jiaqi Pei, Lixia Feng, Nianping Zhang, Yongtai |
author_facet | Ma, Shuwen Li, Jiaqi Pei, Lixia Feng, Nianping Zhang, Yongtai |
author_sort | Ma, Shuwen |
collection | PubMed |
description | Similar to blood, interstitial fluid (ISF) contains exogenous drugs and biomarkers and may therefore substitute blood in drug analysis. However, current ISF extraction techniques require bulky instruments and are both time-consuming and complicated, which has inspired the development of viable alternatives such as those relying on skin or tissue puncturing with microneedles. Currently, microneedles are widely employed for transdermal drug delivery and have been successfully used for ISF extraction by different mechanisms to facilitate subsequent analysis. The integration of microneedles with sensors enables in situ ISF analysis and specific compound monitoring, while the integration of monitoring and delivery functions in wearable devices allows real-time dose modification. Herein, we review the progress in drug analysis based on microneedle-assisted ISF extraction and discuss the related future opportunities and challenges. |
format | Online Article Text |
id | pubmed-9999301 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Xi'an Jiaotong University |
record_format | MEDLINE/PubMed |
spelling | pubmed-99993012023-03-11 Microneedle-based interstitial fluid extraction for drug analysis: Advances, challenges, and prospects Ma, Shuwen Li, Jiaqi Pei, Lixia Feng, Nianping Zhang, Yongtai J Pharm Anal Review Paper Similar to blood, interstitial fluid (ISF) contains exogenous drugs and biomarkers and may therefore substitute blood in drug analysis. However, current ISF extraction techniques require bulky instruments and are both time-consuming and complicated, which has inspired the development of viable alternatives such as those relying on skin or tissue puncturing with microneedles. Currently, microneedles are widely employed for transdermal drug delivery and have been successfully used for ISF extraction by different mechanisms to facilitate subsequent analysis. The integration of microneedles with sensors enables in situ ISF analysis and specific compound monitoring, while the integration of monitoring and delivery functions in wearable devices allows real-time dose modification. Herein, we review the progress in drug analysis based on microneedle-assisted ISF extraction and discuss the related future opportunities and challenges. Xi'an Jiaotong University 2023-02 2023-01-06 /pmc/articles/PMC9999301/ /pubmed/36908860 http://dx.doi.org/10.1016/j.jpha.2022.12.004 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Paper Ma, Shuwen Li, Jiaqi Pei, Lixia Feng, Nianping Zhang, Yongtai Microneedle-based interstitial fluid extraction for drug analysis: Advances, challenges, and prospects |
title | Microneedle-based interstitial fluid extraction for drug analysis: Advances, challenges, and prospects |
title_full | Microneedle-based interstitial fluid extraction for drug analysis: Advances, challenges, and prospects |
title_fullStr | Microneedle-based interstitial fluid extraction for drug analysis: Advances, challenges, and prospects |
title_full_unstemmed | Microneedle-based interstitial fluid extraction for drug analysis: Advances, challenges, and prospects |
title_short | Microneedle-based interstitial fluid extraction for drug analysis: Advances, challenges, and prospects |
title_sort | microneedle-based interstitial fluid extraction for drug analysis: advances, challenges, and prospects |
topic | Review Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999301/ https://www.ncbi.nlm.nih.gov/pubmed/36908860 http://dx.doi.org/10.1016/j.jpha.2022.12.004 |
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