Microneedle-based interstitial fluid extraction for drug analysis: Advances, challenges, and prospects

Similar to blood, interstitial fluid (ISF) contains exogenous drugs and biomarkers and may therefore substitute blood in drug analysis. However, current ISF extraction techniques require bulky instruments and are both time-consuming and complicated, which has inspired the development of viable alter...

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Autores principales: Ma, Shuwen, Li, Jiaqi, Pei, Lixia, Feng, Nianping, Zhang, Yongtai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Xi'an Jiaotong University 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999301/
https://www.ncbi.nlm.nih.gov/pubmed/36908860
http://dx.doi.org/10.1016/j.jpha.2022.12.004
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author Ma, Shuwen
Li, Jiaqi
Pei, Lixia
Feng, Nianping
Zhang, Yongtai
author_facet Ma, Shuwen
Li, Jiaqi
Pei, Lixia
Feng, Nianping
Zhang, Yongtai
author_sort Ma, Shuwen
collection PubMed
description Similar to blood, interstitial fluid (ISF) contains exogenous drugs and biomarkers and may therefore substitute blood in drug analysis. However, current ISF extraction techniques require bulky instruments and are both time-consuming and complicated, which has inspired the development of viable alternatives such as those relying on skin or tissue puncturing with microneedles. Currently, microneedles are widely employed for transdermal drug delivery and have been successfully used for ISF extraction by different mechanisms to facilitate subsequent analysis. The integration of microneedles with sensors enables in situ ISF analysis and specific compound monitoring, while the integration of monitoring and delivery functions in wearable devices allows real-time dose modification. Herein, we review the progress in drug analysis based on microneedle-assisted ISF extraction and discuss the related future opportunities and challenges.
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spelling pubmed-99993012023-03-11 Microneedle-based interstitial fluid extraction for drug analysis: Advances, challenges, and prospects Ma, Shuwen Li, Jiaqi Pei, Lixia Feng, Nianping Zhang, Yongtai J Pharm Anal Review Paper Similar to blood, interstitial fluid (ISF) contains exogenous drugs and biomarkers and may therefore substitute blood in drug analysis. However, current ISF extraction techniques require bulky instruments and are both time-consuming and complicated, which has inspired the development of viable alternatives such as those relying on skin or tissue puncturing with microneedles. Currently, microneedles are widely employed for transdermal drug delivery and have been successfully used for ISF extraction by different mechanisms to facilitate subsequent analysis. The integration of microneedles with sensors enables in situ ISF analysis and specific compound monitoring, while the integration of monitoring and delivery functions in wearable devices allows real-time dose modification. Herein, we review the progress in drug analysis based on microneedle-assisted ISF extraction and discuss the related future opportunities and challenges. Xi'an Jiaotong University 2023-02 2023-01-06 /pmc/articles/PMC9999301/ /pubmed/36908860 http://dx.doi.org/10.1016/j.jpha.2022.12.004 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Paper
Ma, Shuwen
Li, Jiaqi
Pei, Lixia
Feng, Nianping
Zhang, Yongtai
Microneedle-based interstitial fluid extraction for drug analysis: Advances, challenges, and prospects
title Microneedle-based interstitial fluid extraction for drug analysis: Advances, challenges, and prospects
title_full Microneedle-based interstitial fluid extraction for drug analysis: Advances, challenges, and prospects
title_fullStr Microneedle-based interstitial fluid extraction for drug analysis: Advances, challenges, and prospects
title_full_unstemmed Microneedle-based interstitial fluid extraction for drug analysis: Advances, challenges, and prospects
title_short Microneedle-based interstitial fluid extraction for drug analysis: Advances, challenges, and prospects
title_sort microneedle-based interstitial fluid extraction for drug analysis: advances, challenges, and prospects
topic Review Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999301/
https://www.ncbi.nlm.nih.gov/pubmed/36908860
http://dx.doi.org/10.1016/j.jpha.2022.12.004
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