A tumor-selective adenoviral vector platform induces transient antiphospholipid antibodies, without increased risk of thrombosis, in phase 1 clinical studies

Tumor-selective viruses are a novel therapeutic approach for treating cancer. Tumor-Specific Immuno Gene Therapy (T-SIGn) vectors are tumor-selective adenoviral vectors designed to express immunomodulatory transgenes. Prolonged activated partial thromboplastin time (aPTT), associated with the presen...

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Detalles Bibliográficos
Autores principales: Khalil, Danny N., Prieto González-Albo, Isabel, Rosen, Lee, Lillie, Tom, Stacey, Andrea, Parfitt, Lola, Soff, Gerald A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999314/
https://www.ncbi.nlm.nih.gov/pubmed/36897458
http://dx.doi.org/10.1007/s10637-023-01345-8

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