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Invasion characteristics and clinical significance of tumor-associated macrophages in gastrointestinal Krukenberg tumors

BACKGROUND: Tumor-associated macrophages (TAMs) have been used as potential drug targets in preclinical research and clinical trials of various cancers. However, their distribution in Krukenberg tumors (KTs) remains unclear. We investigated the expression and prognostic value of TAMs in patients wit...

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Autores principales: Huang, Zigao, Li, Baojia, Qin, Haiquan, Mo, Xianwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999382/
https://www.ncbi.nlm.nih.gov/pubmed/36910657
http://dx.doi.org/10.3389/fonc.2023.1006183
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author Huang, Zigao
Li, Baojia
Qin, Haiquan
Mo, Xianwei
author_facet Huang, Zigao
Li, Baojia
Qin, Haiquan
Mo, Xianwei
author_sort Huang, Zigao
collection PubMed
description BACKGROUND: Tumor-associated macrophages (TAMs) have been used as potential drug targets in preclinical research and clinical trials of various cancers. However, their distribution in Krukenberg tumors (KTs) remains unclear. We investigated the expression and prognostic value of TAMs in patients with gastrointestinal cancer with KTs. METHODS: The infiltration of various types of TAMs was detected in surgical tissues of 35 patients with KTs using immunohistochemical staining. The level of infiltration of TAMs in tumor nests (TN), tumor stroma (TS), and invasive margin (IM) areas was evaluated. The Kaplan–Meier method and univariate/multivariate Cox regression risk models were used to analyze the relationship between the degree of TAMs invasion and overall survival (OS) and progression-free survival (PFS). RESULTS: The distribution of TAMs exhibited spatial heterogeneity between TN, TS, and IM regions in primary tumor (PT) and KT tissues. TAMs infiltrated in the TN had greater prognostic value and were barely influenced by preoperative neoadjuvant therapy, despite similar grades of invasion in PT and KT tissues. Moreover, the number of CD68+ TAMs in TN of KT tissues was an independent risk factor affecting patient OS, whereas tumor resection scope might be an independent risk factor affecting patient PFS. CONCLUSIONS: In view of the close relationship between TAMs, the tumor microenvironment and patient prognosis, targeting TAMs combined with chemotherapy is expected to become a new approach for the treatment of patients with KTs.
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spelling pubmed-99993822023-03-11 Invasion characteristics and clinical significance of tumor-associated macrophages in gastrointestinal Krukenberg tumors Huang, Zigao Li, Baojia Qin, Haiquan Mo, Xianwei Front Oncol Oncology BACKGROUND: Tumor-associated macrophages (TAMs) have been used as potential drug targets in preclinical research and clinical trials of various cancers. However, their distribution in Krukenberg tumors (KTs) remains unclear. We investigated the expression and prognostic value of TAMs in patients with gastrointestinal cancer with KTs. METHODS: The infiltration of various types of TAMs was detected in surgical tissues of 35 patients with KTs using immunohistochemical staining. The level of infiltration of TAMs in tumor nests (TN), tumor stroma (TS), and invasive margin (IM) areas was evaluated. The Kaplan–Meier method and univariate/multivariate Cox regression risk models were used to analyze the relationship between the degree of TAMs invasion and overall survival (OS) and progression-free survival (PFS). RESULTS: The distribution of TAMs exhibited spatial heterogeneity between TN, TS, and IM regions in primary tumor (PT) and KT tissues. TAMs infiltrated in the TN had greater prognostic value and were barely influenced by preoperative neoadjuvant therapy, despite similar grades of invasion in PT and KT tissues. Moreover, the number of CD68+ TAMs in TN of KT tissues was an independent risk factor affecting patient OS, whereas tumor resection scope might be an independent risk factor affecting patient PFS. CONCLUSIONS: In view of the close relationship between TAMs, the tumor microenvironment and patient prognosis, targeting TAMs combined with chemotherapy is expected to become a new approach for the treatment of patients with KTs. Frontiers Media S.A. 2023-02-24 /pmc/articles/PMC9999382/ /pubmed/36910657 http://dx.doi.org/10.3389/fonc.2023.1006183 Text en Copyright © 2023 Huang, Li, Qin and Mo https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Huang, Zigao
Li, Baojia
Qin, Haiquan
Mo, Xianwei
Invasion characteristics and clinical significance of tumor-associated macrophages in gastrointestinal Krukenberg tumors
title Invasion characteristics and clinical significance of tumor-associated macrophages in gastrointestinal Krukenberg tumors
title_full Invasion characteristics and clinical significance of tumor-associated macrophages in gastrointestinal Krukenberg tumors
title_fullStr Invasion characteristics and clinical significance of tumor-associated macrophages in gastrointestinal Krukenberg tumors
title_full_unstemmed Invasion characteristics and clinical significance of tumor-associated macrophages in gastrointestinal Krukenberg tumors
title_short Invasion characteristics and clinical significance of tumor-associated macrophages in gastrointestinal Krukenberg tumors
title_sort invasion characteristics and clinical significance of tumor-associated macrophages in gastrointestinal krukenberg tumors
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999382/
https://www.ncbi.nlm.nih.gov/pubmed/36910657
http://dx.doi.org/10.3389/fonc.2023.1006183
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AT qinhaiquan invasioncharacteristicsandclinicalsignificanceoftumorassociatedmacrophagesingastrointestinalkrukenbergtumors
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