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Sex-based epidemiological and immunovirological characteristics of people living with HIV in current follow-up at a tertiary hospital: a comparative retrospective study, Catalonia, Spain, 1982 to 2020
BACKGROUND: Epidemiological and immunovirological features of people living with HIV (PLWH) can vary by sex. AIM: To investigate, particularly according to sex, characteristics of PLWH who consulted a tertiary hospital in Barcelona, Spain, in 1982–2020. METHODS: PLWH, still in active follow-up in 20...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
European Centre for Disease Prevention and Control (ECDC)
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999459/ https://www.ncbi.nlm.nih.gov/pubmed/36892474 http://dx.doi.org/10.2807/1560-7917.ES.2023.28.10.2200317 |
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author | Toyos, Sara Berrocal, Leire González-Cordón, Ana Inciarte, Alexy de la Mora, Lorena Martínez-Rebollar, María Laguno, Montserrat Fernández, Emma Ambrosioni, Juan Chivite, Iván de Lazzari, Elisa Blanco, José Luis Martínez, Esteban Miró, José M Mallolas, Josep Torres, Berta |
author_facet | Toyos, Sara Berrocal, Leire González-Cordón, Ana Inciarte, Alexy de la Mora, Lorena Martínez-Rebollar, María Laguno, Montserrat Fernández, Emma Ambrosioni, Juan Chivite, Iván de Lazzari, Elisa Blanco, José Luis Martínez, Esteban Miró, José M Mallolas, Josep Torres, Berta |
author_sort | Toyos, Sara |
collection | PubMed |
description | BACKGROUND: Epidemiological and immunovirological features of people living with HIV (PLWH) can vary by sex. AIM: To investigate, particularly according to sex, characteristics of PLWH who consulted a tertiary hospital in Barcelona, Spain, in 1982–2020. METHODS: PLWH, still in active follow-up in 2020 were retrospectively analysed by sex, age at diagnosis, age at data extraction (December 2020), birth place, CD4(+) cell counts, and virological failure. RESULTS: In total, 5,377 PLWH (comprising 828 women; 15%) were included. HIV diagnoses in women appeared to decrease from the 1990s, representing 7.4% (61/828) of new diagnoses in 2015–2020. From 1997, proportions of new HIV diagnoses from patients born in Latin America seemed to increase; moreover, for women born outside of Spain, the median age at diagnosis appeared to become younger than for those born in Spain, with significant differences observed in 2005–2009 and 2010–2014 (31 vs 39 years (p = 0.001), and 32 vs 42 years (p < 0.001) respectively), but not in 2015–2020 (35 vs 42 years; p = 0.254). Among women, proportions of late diagnoses (CD4(+) cells/mm(3) < 350) were higher than men (significantly in 2015–2020: 62% (32/52) vs 46% (300/656); p = 0.030). Initially, virological failure rates were higher in women than men, but they were similar in 2015–2020 (12% (6/52) vs 8% (55/659); p = 0.431). Women ≥ 50 years old represented 68% (564/828) of women actively followed up in 2020. CONCLUSIONS: Women still have higher rates of late HIV diagnoses than men. Among currently-followed-up women, ≥ 50 year-olds, who need age-adapted care represent a high percentage. Stratifying PLWH by sex matters for HIV prevention and control interventions. |
format | Online Article Text |
id | pubmed-9999459 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | European Centre for Disease Prevention and Control (ECDC) |
record_format | MEDLINE/PubMed |
spelling | pubmed-99994592023-03-11 Sex-based epidemiological and immunovirological characteristics of people living with HIV in current follow-up at a tertiary hospital: a comparative retrospective study, Catalonia, Spain, 1982 to 2020 Toyos, Sara Berrocal, Leire González-Cordón, Ana Inciarte, Alexy de la Mora, Lorena Martínez-Rebollar, María Laguno, Montserrat Fernández, Emma Ambrosioni, Juan Chivite, Iván de Lazzari, Elisa Blanco, José Luis Martínez, Esteban Miró, José M Mallolas, Josep Torres, Berta Euro Surveill Research BACKGROUND: Epidemiological and immunovirological features of people living with HIV (PLWH) can vary by sex. AIM: To investigate, particularly according to sex, characteristics of PLWH who consulted a tertiary hospital in Barcelona, Spain, in 1982–2020. METHODS: PLWH, still in active follow-up in 2020 were retrospectively analysed by sex, age at diagnosis, age at data extraction (December 2020), birth place, CD4(+) cell counts, and virological failure. RESULTS: In total, 5,377 PLWH (comprising 828 women; 15%) were included. HIV diagnoses in women appeared to decrease from the 1990s, representing 7.4% (61/828) of new diagnoses in 2015–2020. From 1997, proportions of new HIV diagnoses from patients born in Latin America seemed to increase; moreover, for women born outside of Spain, the median age at diagnosis appeared to become younger than for those born in Spain, with significant differences observed in 2005–2009 and 2010–2014 (31 vs 39 years (p = 0.001), and 32 vs 42 years (p < 0.001) respectively), but not in 2015–2020 (35 vs 42 years; p = 0.254). Among women, proportions of late diagnoses (CD4(+) cells/mm(3) < 350) were higher than men (significantly in 2015–2020: 62% (32/52) vs 46% (300/656); p = 0.030). Initially, virological failure rates were higher in women than men, but they were similar in 2015–2020 (12% (6/52) vs 8% (55/659); p = 0.431). Women ≥ 50 years old represented 68% (564/828) of women actively followed up in 2020. CONCLUSIONS: Women still have higher rates of late HIV diagnoses than men. Among currently-followed-up women, ≥ 50 year-olds, who need age-adapted care represent a high percentage. Stratifying PLWH by sex matters for HIV prevention and control interventions. European Centre for Disease Prevention and Control (ECDC) 2023-03-09 /pmc/articles/PMC9999459/ /pubmed/36892474 http://dx.doi.org/10.2807/1560-7917.ES.2023.28.10.2200317 Text en This article is copyright of the authors or their affiliated institutions, 2023. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made. |
spellingShingle | Research Toyos, Sara Berrocal, Leire González-Cordón, Ana Inciarte, Alexy de la Mora, Lorena Martínez-Rebollar, María Laguno, Montserrat Fernández, Emma Ambrosioni, Juan Chivite, Iván de Lazzari, Elisa Blanco, José Luis Martínez, Esteban Miró, José M Mallolas, Josep Torres, Berta Sex-based epidemiological and immunovirological characteristics of people living with HIV in current follow-up at a tertiary hospital: a comparative retrospective study, Catalonia, Spain, 1982 to 2020 |
title | Sex-based epidemiological and immunovirological characteristics of people living with HIV in current follow-up at a tertiary hospital: a comparative retrospective study, Catalonia, Spain, 1982 to 2020 |
title_full | Sex-based epidemiological and immunovirological characteristics of people living with HIV in current follow-up at a tertiary hospital: a comparative retrospective study, Catalonia, Spain, 1982 to 2020 |
title_fullStr | Sex-based epidemiological and immunovirological characteristics of people living with HIV in current follow-up at a tertiary hospital: a comparative retrospective study, Catalonia, Spain, 1982 to 2020 |
title_full_unstemmed | Sex-based epidemiological and immunovirological characteristics of people living with HIV in current follow-up at a tertiary hospital: a comparative retrospective study, Catalonia, Spain, 1982 to 2020 |
title_short | Sex-based epidemiological and immunovirological characteristics of people living with HIV in current follow-up at a tertiary hospital: a comparative retrospective study, Catalonia, Spain, 1982 to 2020 |
title_sort | sex-based epidemiological and immunovirological characteristics of people living with hiv in current follow-up at a tertiary hospital: a comparative retrospective study, catalonia, spain, 1982 to 2020 |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999459/ https://www.ncbi.nlm.nih.gov/pubmed/36892474 http://dx.doi.org/10.2807/1560-7917.ES.2023.28.10.2200317 |
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