Multidrug-resistant Neisseria gonorrhoeae isolate SE690: mosaic penA-60.001 gene causing ceftriaxone resistance internationally has spread to the more antimicrobial-susceptible genomic lineage, Sweden, September 2022

We report a ceftriaxone-resistant, multidrug-resistant urogenital Neisseria gonorrhoeae in a female sex worker in Sweden, September 2022, who was treated with ceftriaxone 1 g, but did not return for test-of-cure. Whole genome sequencing of isolate SE690 identified MLST ST8130, NG-STAR CC1885 (new NG...

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Autores principales: Golparian, Daniel, Vestberg, Nora, Södersten, Wiktor, Jacobsson, Susanne, Ohnishi, Makoto, Fang, Hong, Bhattarai, Karin Haij, Unemo, Magnus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2023
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999460/
https://www.ncbi.nlm.nih.gov/pubmed/36892469
http://dx.doi.org/10.2807/1560-7917.ES.2023.28.10.2300125
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author Golparian, Daniel
Vestberg, Nora
Södersten, Wiktor
Jacobsson, Susanne
Ohnishi, Makoto
Fang, Hong
Bhattarai, Karin Haij
Unemo, Magnus
author_facet Golparian, Daniel
Vestberg, Nora
Södersten, Wiktor
Jacobsson, Susanne
Ohnishi, Makoto
Fang, Hong
Bhattarai, Karin Haij
Unemo, Magnus
author_sort Golparian, Daniel
collection PubMed
description We report a ceftriaxone-resistant, multidrug-resistant urogenital Neisseria gonorrhoeae in a female sex worker in Sweden, September 2022, who was treated with ceftriaxone 1 g, but did not return for test-of-cure. Whole genome sequencing of isolate SE690 identified MLST ST8130, NG-STAR CC1885 (new NG-STAR ST4859) and mosaic penA-60.001. The latter, causing ceftriaxone resistance in the internationally spreading FC428 clone, has now also spread to the more antimicrobial-susceptible genomic lineage B, showing that strains across the gonococcal phylogeny can develop ceftriaxone resistance.
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spelling pubmed-99994602023-03-11 Multidrug-resistant Neisseria gonorrhoeae isolate SE690: mosaic penA-60.001 gene causing ceftriaxone resistance internationally has spread to the more antimicrobial-susceptible genomic lineage, Sweden, September 2022 Golparian, Daniel Vestberg, Nora Södersten, Wiktor Jacobsson, Susanne Ohnishi, Makoto Fang, Hong Bhattarai, Karin Haij Unemo, Magnus Euro Surveill Rapid Communication We report a ceftriaxone-resistant, multidrug-resistant urogenital Neisseria gonorrhoeae in a female sex worker in Sweden, September 2022, who was treated with ceftriaxone 1 g, but did not return for test-of-cure. Whole genome sequencing of isolate SE690 identified MLST ST8130, NG-STAR CC1885 (new NG-STAR ST4859) and mosaic penA-60.001. The latter, causing ceftriaxone resistance in the internationally spreading FC428 clone, has now also spread to the more antimicrobial-susceptible genomic lineage B, showing that strains across the gonococcal phylogeny can develop ceftriaxone resistance. European Centre for Disease Prevention and Control (ECDC) 2023-03-09 /pmc/articles/PMC9999460/ /pubmed/36892469 http://dx.doi.org/10.2807/1560-7917.ES.2023.28.10.2300125 Text en This article is copyright of the authors or their affiliated institutions, 2023. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Rapid Communication
Golparian, Daniel
Vestberg, Nora
Södersten, Wiktor
Jacobsson, Susanne
Ohnishi, Makoto
Fang, Hong
Bhattarai, Karin Haij
Unemo, Magnus
Multidrug-resistant Neisseria gonorrhoeae isolate SE690: mosaic penA-60.001 gene causing ceftriaxone resistance internationally has spread to the more antimicrobial-susceptible genomic lineage, Sweden, September 2022
title Multidrug-resistant Neisseria gonorrhoeae isolate SE690: mosaic penA-60.001 gene causing ceftriaxone resistance internationally has spread to the more antimicrobial-susceptible genomic lineage, Sweden, September 2022
title_full Multidrug-resistant Neisseria gonorrhoeae isolate SE690: mosaic penA-60.001 gene causing ceftriaxone resistance internationally has spread to the more antimicrobial-susceptible genomic lineage, Sweden, September 2022
title_fullStr Multidrug-resistant Neisseria gonorrhoeae isolate SE690: mosaic penA-60.001 gene causing ceftriaxone resistance internationally has spread to the more antimicrobial-susceptible genomic lineage, Sweden, September 2022
title_full_unstemmed Multidrug-resistant Neisseria gonorrhoeae isolate SE690: mosaic penA-60.001 gene causing ceftriaxone resistance internationally has spread to the more antimicrobial-susceptible genomic lineage, Sweden, September 2022
title_short Multidrug-resistant Neisseria gonorrhoeae isolate SE690: mosaic penA-60.001 gene causing ceftriaxone resistance internationally has spread to the more antimicrobial-susceptible genomic lineage, Sweden, September 2022
title_sort multidrug-resistant neisseria gonorrhoeae isolate se690: mosaic pena-60.001 gene causing ceftriaxone resistance internationally has spread to the more antimicrobial-susceptible genomic lineage, sweden, september 2022
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999460/
https://www.ncbi.nlm.nih.gov/pubmed/36892469
http://dx.doi.org/10.2807/1560-7917.ES.2023.28.10.2300125
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