SETD2 non genomic loss of function in advanced systemic mastocytosis is mediated by an Aurora kinase A/MDM2 axis and can be therapeutically targeted

BACKGROUND: The SETD2 tumor suppressor gene encodes a histone methyltransferase that safeguards transcription fidelity and genomic integrity via trimethylation of histone H3 lysine 36 (H3K36Me3). SETD2 loss of function has been observed in solid and hematologic malignancies. We have recently reporte...

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Detalles Bibliográficos
Autores principales: Mancini, Manuela, Monaldi, Cecilia, De Santis, Sara, Papayannidis, Cristina, Rondoni, Michela, Sartor, Chiara, Bruno, Samantha, Pagano, Livio, Criscuolo, Marianna, Zanotti, Roberta, Bonifacio, Massimiliano, Tosi, Patrizia, Arock, Michel, Valent, Peter, Cavo, Michele, Soverini, Simona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999558/
https://www.ncbi.nlm.nih.gov/pubmed/36894973
http://dx.doi.org/10.1186/s40364-023-00468-7

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