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Impact of oral statin therapy on clinical outcomes in patients with cT1 breast cancer

PURPOSE: A previous meta-analysis examining the relationship between statin use and breast cancer reported that the inhibitory effect of statins on breast cancer may be more pronounced in early-stage cases. In this study, we aimed to investigate the effects of hyperlipidemia treatment at the time of...

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Autores principales: Takada, Koji, Kashiwagi, Shinichiro, Iimori, Nozomi, Kouhashi, Rika, Yabumoto, Akimichi, Goto, Wataru, Asano, Yuka, Tauchi, Yukie, Morisaki, Tamami, Ogisawa, Kana, Shibutani, Masatsune, Tanaka, Hiroaki, Maeda, Kiyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999569/
https://www.ncbi.nlm.nih.gov/pubmed/36894884
http://dx.doi.org/10.1186/s12885-023-10631-w
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author Takada, Koji
Kashiwagi, Shinichiro
Iimori, Nozomi
Kouhashi, Rika
Yabumoto, Akimichi
Goto, Wataru
Asano, Yuka
Tauchi, Yukie
Morisaki, Tamami
Ogisawa, Kana
Shibutani, Masatsune
Tanaka, Hiroaki
Maeda, Kiyoshi
author_facet Takada, Koji
Kashiwagi, Shinichiro
Iimori, Nozomi
Kouhashi, Rika
Yabumoto, Akimichi
Goto, Wataru
Asano, Yuka
Tauchi, Yukie
Morisaki, Tamami
Ogisawa, Kana
Shibutani, Masatsune
Tanaka, Hiroaki
Maeda, Kiyoshi
author_sort Takada, Koji
collection PubMed
description PURPOSE: A previous meta-analysis examining the relationship between statin use and breast cancer reported that the inhibitory effect of statins on breast cancer may be more pronounced in early-stage cases. In this study, we aimed to investigate the effects of hyperlipidemia treatment at the time of breast cancer diagnosis and to examine its correlation with metastasis to axillary lymph nodes among patients with so-called cT1 breast cancer whose primary lesion was 2 cm or less and was pathologically evaluated by sentinel lymph node biopsy or axillary lymph node dissection. We also investigated the effects of hyperlipidemic drugs on the prognosis of patients with early-stage breast cancer. METHODS: After excluding cases that did not meet the criteria, we analyzed data from 719 patients who were diagnosed with breast cancer, with a primary lesion of 2 cm or less identified by preoperative imaging, and who underwent surgery without preoperative chemotherapy. RESULTS: Regarding hyperlipidemia drugs, no correlation was found between statin use and lymph node metastasis (p = 0.226), although a correlation was found between lipophilic statin use and lymph node metastasis (p = 0.042). Also, the disease-free survival periods were prolonged following treatment of hyperlipidemia (p = 0.047, hazard ratio: 0.399) and statin administration (p = 0.028, hazard ratio: 0.328). CONCLUSION: In cT1 breast cancer, the results suggest that oral statin therapy may contribute to favorable outcomes. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12885-023-10631-w.
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spelling pubmed-99995692023-03-11 Impact of oral statin therapy on clinical outcomes in patients with cT1 breast cancer Takada, Koji Kashiwagi, Shinichiro Iimori, Nozomi Kouhashi, Rika Yabumoto, Akimichi Goto, Wataru Asano, Yuka Tauchi, Yukie Morisaki, Tamami Ogisawa, Kana Shibutani, Masatsune Tanaka, Hiroaki Maeda, Kiyoshi BMC Cancer Research Article PURPOSE: A previous meta-analysis examining the relationship between statin use and breast cancer reported that the inhibitory effect of statins on breast cancer may be more pronounced in early-stage cases. In this study, we aimed to investigate the effects of hyperlipidemia treatment at the time of breast cancer diagnosis and to examine its correlation with metastasis to axillary lymph nodes among patients with so-called cT1 breast cancer whose primary lesion was 2 cm or less and was pathologically evaluated by sentinel lymph node biopsy or axillary lymph node dissection. We also investigated the effects of hyperlipidemic drugs on the prognosis of patients with early-stage breast cancer. METHODS: After excluding cases that did not meet the criteria, we analyzed data from 719 patients who were diagnosed with breast cancer, with a primary lesion of 2 cm or less identified by preoperative imaging, and who underwent surgery without preoperative chemotherapy. RESULTS: Regarding hyperlipidemia drugs, no correlation was found between statin use and lymph node metastasis (p = 0.226), although a correlation was found between lipophilic statin use and lymph node metastasis (p = 0.042). Also, the disease-free survival periods were prolonged following treatment of hyperlipidemia (p = 0.047, hazard ratio: 0.399) and statin administration (p = 0.028, hazard ratio: 0.328). CONCLUSION: In cT1 breast cancer, the results suggest that oral statin therapy may contribute to favorable outcomes. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12885-023-10631-w. BioMed Central 2023-03-09 /pmc/articles/PMC9999569/ /pubmed/36894884 http://dx.doi.org/10.1186/s12885-023-10631-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Takada, Koji
Kashiwagi, Shinichiro
Iimori, Nozomi
Kouhashi, Rika
Yabumoto, Akimichi
Goto, Wataru
Asano, Yuka
Tauchi, Yukie
Morisaki, Tamami
Ogisawa, Kana
Shibutani, Masatsune
Tanaka, Hiroaki
Maeda, Kiyoshi
Impact of oral statin therapy on clinical outcomes in patients with cT1 breast cancer
title Impact of oral statin therapy on clinical outcomes in patients with cT1 breast cancer
title_full Impact of oral statin therapy on clinical outcomes in patients with cT1 breast cancer
title_fullStr Impact of oral statin therapy on clinical outcomes in patients with cT1 breast cancer
title_full_unstemmed Impact of oral statin therapy on clinical outcomes in patients with cT1 breast cancer
title_short Impact of oral statin therapy on clinical outcomes in patients with cT1 breast cancer
title_sort impact of oral statin therapy on clinical outcomes in patients with ct1 breast cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999569/
https://www.ncbi.nlm.nih.gov/pubmed/36894884
http://dx.doi.org/10.1186/s12885-023-10631-w
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