Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment

Metabolic reprogramming is one of the hallmarks of cancer. As nutrients are scarce in the tumor microenvironment (TME), tumor cells adopt multiple metabolic adaptations to meet their growth requirements. Metabolic reprogramming is not only present in tumor cells, but exosomal cargos mediates interce...

Descripción completa

Detalles Bibliográficos
Autores principales: Tan, Shiming, Yang, Yiqing, Yang, Wenjuan, Han, Yaqian, Huang, Lisheng, Yang, Ruiqian, Hu, Zifan, Tao, Yi, Liu, Lin, Li, Yun, Oyang, Linda, Lin, Jinguan, Peng, Qiu, Jiang, Xianjie, Xu, Xuemeng, Xia, Longzheng, Peng, Mingjing, Wu, Nayiyuan, Tang, Yanyan, Cao, Deliang, Liao, Qianjin, Zhou, Yujuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999652/
https://www.ncbi.nlm.nih.gov/pubmed/36899389
http://dx.doi.org/10.1186/s13046-023-02634-z
_version_ 1784903702553821184
author Tan, Shiming
Yang, Yiqing
Yang, Wenjuan
Han, Yaqian
Huang, Lisheng
Yang, Ruiqian
Hu, Zifan
Tao, Yi
Liu, Lin
Li, Yun
Oyang, Linda
Lin, Jinguan
Peng, Qiu
Jiang, Xianjie
Xu, Xuemeng
Xia, Longzheng
Peng, Mingjing
Wu, Nayiyuan
Tang, Yanyan
Cao, Deliang
Liao, Qianjin
Zhou, Yujuan
author_facet Tan, Shiming
Yang, Yiqing
Yang, Wenjuan
Han, Yaqian
Huang, Lisheng
Yang, Ruiqian
Hu, Zifan
Tao, Yi
Liu, Lin
Li, Yun
Oyang, Linda
Lin, Jinguan
Peng, Qiu
Jiang, Xianjie
Xu, Xuemeng
Xia, Longzheng
Peng, Mingjing
Wu, Nayiyuan
Tang, Yanyan
Cao, Deliang
Liao, Qianjin
Zhou, Yujuan
author_sort Tan, Shiming
collection PubMed
description Metabolic reprogramming is one of the hallmarks of cancer. As nutrients are scarce in the tumor microenvironment (TME), tumor cells adopt multiple metabolic adaptations to meet their growth requirements. Metabolic reprogramming is not only present in tumor cells, but exosomal cargos mediates intercellular communication between tumor cells and non-tumor cells in the TME, inducing metabolic remodeling to create an outpost of microvascular enrichment and immune escape. Here, we highlight the composition and characteristics of TME, meanwhile summarize the components of exosomal cargos and their corresponding sorting mode. Functionally, these exosomal cargos-mediated metabolic reprogramming improves the "soil" for tumor growth and metastasis. Moreover, we discuss the abnormal tumor metabolism targeted by exosomal cargos and its potential antitumor therapy. In conclusion, this review updates the current role of exosomal cargos in TME metabolic reprogramming and enriches the future application scenarios of exosomes.
format Online
Article
Text
id pubmed-9999652
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-99996522023-03-11 Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment Tan, Shiming Yang, Yiqing Yang, Wenjuan Han, Yaqian Huang, Lisheng Yang, Ruiqian Hu, Zifan Tao, Yi Liu, Lin Li, Yun Oyang, Linda Lin, Jinguan Peng, Qiu Jiang, Xianjie Xu, Xuemeng Xia, Longzheng Peng, Mingjing Wu, Nayiyuan Tang, Yanyan Cao, Deliang Liao, Qianjin Zhou, Yujuan J Exp Clin Cancer Res Review Metabolic reprogramming is one of the hallmarks of cancer. As nutrients are scarce in the tumor microenvironment (TME), tumor cells adopt multiple metabolic adaptations to meet their growth requirements. Metabolic reprogramming is not only present in tumor cells, but exosomal cargos mediates intercellular communication between tumor cells and non-tumor cells in the TME, inducing metabolic remodeling to create an outpost of microvascular enrichment and immune escape. Here, we highlight the composition and characteristics of TME, meanwhile summarize the components of exosomal cargos and their corresponding sorting mode. Functionally, these exosomal cargos-mediated metabolic reprogramming improves the "soil" for tumor growth and metastasis. Moreover, we discuss the abnormal tumor metabolism targeted by exosomal cargos and its potential antitumor therapy. In conclusion, this review updates the current role of exosomal cargos in TME metabolic reprogramming and enriches the future application scenarios of exosomes. BioMed Central 2023-03-10 /pmc/articles/PMC9999652/ /pubmed/36899389 http://dx.doi.org/10.1186/s13046-023-02634-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Tan, Shiming
Yang, Yiqing
Yang, Wenjuan
Han, Yaqian
Huang, Lisheng
Yang, Ruiqian
Hu, Zifan
Tao, Yi
Liu, Lin
Li, Yun
Oyang, Linda
Lin, Jinguan
Peng, Qiu
Jiang, Xianjie
Xu, Xuemeng
Xia, Longzheng
Peng, Mingjing
Wu, Nayiyuan
Tang, Yanyan
Cao, Deliang
Liao, Qianjin
Zhou, Yujuan
Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment
title Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment
title_full Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment
title_fullStr Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment
title_full_unstemmed Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment
title_short Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment
title_sort exosomal cargos-mediated metabolic reprogramming in tumor microenvironment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999652/
https://www.ncbi.nlm.nih.gov/pubmed/36899389
http://dx.doi.org/10.1186/s13046-023-02634-z
work_keys_str_mv AT tanshiming exosomalcargosmediatedmetabolicreprogrammingintumormicroenvironment
AT yangyiqing exosomalcargosmediatedmetabolicreprogrammingintumormicroenvironment
AT yangwenjuan exosomalcargosmediatedmetabolicreprogrammingintumormicroenvironment
AT hanyaqian exosomalcargosmediatedmetabolicreprogrammingintumormicroenvironment
AT huanglisheng exosomalcargosmediatedmetabolicreprogrammingintumormicroenvironment
AT yangruiqian exosomalcargosmediatedmetabolicreprogrammingintumormicroenvironment
AT huzifan exosomalcargosmediatedmetabolicreprogrammingintumormicroenvironment
AT taoyi exosomalcargosmediatedmetabolicreprogrammingintumormicroenvironment
AT liulin exosomalcargosmediatedmetabolicreprogrammingintumormicroenvironment
AT liyun exosomalcargosmediatedmetabolicreprogrammingintumormicroenvironment
AT oyanglinda exosomalcargosmediatedmetabolicreprogrammingintumormicroenvironment
AT linjinguan exosomalcargosmediatedmetabolicreprogrammingintumormicroenvironment
AT pengqiu exosomalcargosmediatedmetabolicreprogrammingintumormicroenvironment
AT jiangxianjie exosomalcargosmediatedmetabolicreprogrammingintumormicroenvironment
AT xuxuemeng exosomalcargosmediatedmetabolicreprogrammingintumormicroenvironment
AT xialongzheng exosomalcargosmediatedmetabolicreprogrammingintumormicroenvironment
AT pengmingjing exosomalcargosmediatedmetabolicreprogrammingintumormicroenvironment
AT wunayiyuan exosomalcargosmediatedmetabolicreprogrammingintumormicroenvironment
AT tangyanyan exosomalcargosmediatedmetabolicreprogrammingintumormicroenvironment
AT caodeliang exosomalcargosmediatedmetabolicreprogrammingintumormicroenvironment
AT liaoqianjin exosomalcargosmediatedmetabolicreprogrammingintumormicroenvironment
AT zhouyujuan exosomalcargosmediatedmetabolicreprogrammingintumormicroenvironment

Ejemplares similares