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Low-Grade Oncocytic Tumor: Report of Two Cases of An Emerging Entity in the Spectrum of Oncocytic Renal Neoplasms

Low-grade Oncocytic Tumor (LOT) of kidney is an emerging neoplasm that forms an important differential diagnosis in a spectrum of entities with oncocytic morphology. It has overlapping features with renal oncocytoma and eosinophilic variant of chromophobe renal cell carcinoma, but with distinct clin...

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Autores principales: Sharma, Divakar, Pai, Trupti, Prakash, Gagan, Desai, Sangeeta, Menon, Santosh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Federation of Turkish Pathology Societies 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999681/
https://www.ncbi.nlm.nih.gov/pubmed/34514579
http://dx.doi.org/10.5146/tjpath.2021.01549
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author Sharma, Divakar
Pai, Trupti
Prakash, Gagan
Desai, Sangeeta
Menon, Santosh
author_facet Sharma, Divakar
Pai, Trupti
Prakash, Gagan
Desai, Sangeeta
Menon, Santosh
author_sort Sharma, Divakar
collection PubMed
description Low-grade Oncocytic Tumor (LOT) of kidney is an emerging neoplasm that forms an important differential diagnosis in a spectrum of entities with oncocytic morphology. It has overlapping features with renal oncocytoma and eosinophilic variant of chromophobe renal cell carcinoma, but with distinct clinical, histomorphological and immunohistochemical features. LOT exhibits characteristic low grade oncocytic morphology with a CD117 negative/CK7 positive immunophenotype. Herein, we describe two cases of this emerging entity, LOT, with emphasis on the diagnostic aspects, including the histomorphology, immunoprofile and discussion on the close differentials.
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spelling pubmed-99996812023-04-21 Low-Grade Oncocytic Tumor: Report of Two Cases of An Emerging Entity in the Spectrum of Oncocytic Renal Neoplasms Sharma, Divakar Pai, Trupti Prakash, Gagan Desai, Sangeeta Menon, Santosh Turk Patoloji Derg Case Report Low-grade Oncocytic Tumor (LOT) of kidney is an emerging neoplasm that forms an important differential diagnosis in a spectrum of entities with oncocytic morphology. It has overlapping features with renal oncocytoma and eosinophilic variant of chromophobe renal cell carcinoma, but with distinct clinical, histomorphological and immunohistochemical features. LOT exhibits characteristic low grade oncocytic morphology with a CD117 negative/CK7 positive immunophenotype. Herein, we describe two cases of this emerging entity, LOT, with emphasis on the diagnostic aspects, including the histomorphology, immunoprofile and discussion on the close differentials. Federation of Turkish Pathology Societies 2022-05-19 /pmc/articles/PMC9999681/ /pubmed/34514579 http://dx.doi.org/10.5146/tjpath.2021.01549 Text en Copyright © 2022 The Author(s). https://creativecommons.org/licenses/by/4.0/This is an open-access article published by Federation of Turkish Pathology Societies under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is properly cited. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Case Report
Sharma, Divakar
Pai, Trupti
Prakash, Gagan
Desai, Sangeeta
Menon, Santosh
Low-Grade Oncocytic Tumor: Report of Two Cases of An Emerging Entity in the Spectrum of Oncocytic Renal Neoplasms
title Low-Grade Oncocytic Tumor: Report of Two Cases of An Emerging Entity in the Spectrum of Oncocytic Renal Neoplasms
title_full Low-Grade Oncocytic Tumor: Report of Two Cases of An Emerging Entity in the Spectrum of Oncocytic Renal Neoplasms
title_fullStr Low-Grade Oncocytic Tumor: Report of Two Cases of An Emerging Entity in the Spectrum of Oncocytic Renal Neoplasms
title_full_unstemmed Low-Grade Oncocytic Tumor: Report of Two Cases of An Emerging Entity in the Spectrum of Oncocytic Renal Neoplasms
title_short Low-Grade Oncocytic Tumor: Report of Two Cases of An Emerging Entity in the Spectrum of Oncocytic Renal Neoplasms
title_sort low-grade oncocytic tumor: report of two cases of an emerging entity in the spectrum of oncocytic renal neoplasms
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999681/
https://www.ncbi.nlm.nih.gov/pubmed/34514579
http://dx.doi.org/10.5146/tjpath.2021.01549
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