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An Unusual Nodular Tumour of the Penile Shaft with Clinicopathologic and Immunohistochemical Correlation

Granular cell tumours are uncommon acquired benign tumours of nerve sheath origin that are usually seen in the head and neck region and upper aero-digestive tract. They usually present as solitary small sized nodules in middle age. The tumour is usually benign and composed of sheets of large sized c...

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Autores principales: Elhence, Poonam Abhay, Vedant, Deepak, Singh, Saurabh, Pareek, Puneet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Federation of Turkish Pathology Societies 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999694/
https://www.ncbi.nlm.nih.gov/pubmed/34514564
http://dx.doi.org/10.5146/tjpath.2021.01534
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author Elhence, Poonam Abhay
Vedant, Deepak
Singh, Saurabh
Pareek, Puneet
author_facet Elhence, Poonam Abhay
Vedant, Deepak
Singh, Saurabh
Pareek, Puneet
author_sort Elhence, Poonam Abhay
collection PubMed
description Granular cell tumours are uncommon acquired benign tumours of nerve sheath origin that are usually seen in the head and neck region and upper aero-digestive tract. They usually present as solitary small sized nodules in middle age. The tumour is usually benign and composed of sheets of large sized cells with abundant granular cytoplasm containing lysosomal macro-inclusions known as pustulo-ovoid bodies of Milian (POB) that represent the heterogeneity of the lysosomes. No well-established criteria for malignancy have been described for this tumour. In this article, we have discussed a rare case of granular cell tumour of the penis with its characteristic histomorphology and immunohistochemistry and relevant differential diagnosis.
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spelling pubmed-99996942023-04-21 An Unusual Nodular Tumour of the Penile Shaft with Clinicopathologic and Immunohistochemical Correlation Elhence, Poonam Abhay Vedant, Deepak Singh, Saurabh Pareek, Puneet Turk Patoloji Derg Case Report Granular cell tumours are uncommon acquired benign tumours of nerve sheath origin that are usually seen in the head and neck region and upper aero-digestive tract. They usually present as solitary small sized nodules in middle age. The tumour is usually benign and composed of sheets of large sized cells with abundant granular cytoplasm containing lysosomal macro-inclusions known as pustulo-ovoid bodies of Milian (POB) that represent the heterogeneity of the lysosomes. No well-established criteria for malignancy have been described for this tumour. In this article, we have discussed a rare case of granular cell tumour of the penis with its characteristic histomorphology and immunohistochemistry and relevant differential diagnosis. Federation of Turkish Pathology Societies 2022-01-21 /pmc/articles/PMC9999694/ /pubmed/34514564 http://dx.doi.org/10.5146/tjpath.2021.01534 Text en Copyright © 2022 The Author(s). https://creativecommons.org/licenses/by/4.0/This is an open-access article published by Federation of Turkish Pathology Societies under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is properly cited. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Case Report
Elhence, Poonam Abhay
Vedant, Deepak
Singh, Saurabh
Pareek, Puneet
An Unusual Nodular Tumour of the Penile Shaft with Clinicopathologic and Immunohistochemical Correlation
title An Unusual Nodular Tumour of the Penile Shaft with Clinicopathologic and Immunohistochemical Correlation
title_full An Unusual Nodular Tumour of the Penile Shaft with Clinicopathologic and Immunohistochemical Correlation
title_fullStr An Unusual Nodular Tumour of the Penile Shaft with Clinicopathologic and Immunohistochemical Correlation
title_full_unstemmed An Unusual Nodular Tumour of the Penile Shaft with Clinicopathologic and Immunohistochemical Correlation
title_short An Unusual Nodular Tumour of the Penile Shaft with Clinicopathologic and Immunohistochemical Correlation
title_sort unusual nodular tumour of the penile shaft with clinicopathologic and immunohistochemical correlation
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999694/
https://www.ncbi.nlm.nih.gov/pubmed/34514564
http://dx.doi.org/10.5146/tjpath.2021.01534
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