Eosinophilic Solid and Cystic Renal Cell Carcinoma: From Unclassified to Classified, A Case Report

Eosinophilic solid and cystic renal cell carcinoma (ESC RCC) is a novel tumour with unique morphological and immunohistochemical features. It is a recently described entity after the 2016 World Health Organization Classification of Tumours of the Urinary System and Male Genital Organs and is charact...

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Autores principales: Sharma, Rashim, Thirunavukkarasu, Balamurugan, Elhence, Poonam, Rodha, Mahaveer Singh, Sureka, Binit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Federation of Turkish Pathology Societies 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999703/
https://www.ncbi.nlm.nih.gov/pubmed/34514562
http://dx.doi.org/10.5146/tjpath.2021.01531
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author Sharma, Rashim
Thirunavukkarasu, Balamurugan
Elhence, Poonam
Rodha, Mahaveer Singh
Sureka, Binit
author_facet Sharma, Rashim
Thirunavukkarasu, Balamurugan
Elhence, Poonam
Rodha, Mahaveer Singh
Sureka, Binit
author_sort Sharma, Rashim
collection PubMed
description Eosinophilic solid and cystic renal cell carcinoma (ESC RCC) is a novel tumour with unique morphological and immunohistochemical features. It is a recently described entity after the 2016 World Health Organization Classification of Tumours of the Urinary System and Male Genital Organs and is characterised by a solid cystic tumour composed of polygonal cells with voluminous eosinophilic cytoplasm and CK20 positivity. This tumour has uncertain malignant potential and also has an association with tuberous sclerosis complex (TSC). Sarcomatoid differentiation has not been reported in ESC RCC till now. ESC RCC poses a diagnostic challenge as many eosinophilic/oncocytic renal tumours are included in the differentials. We present a case of ESC RCC with sarcomatoid differentiation in an elderly female without any clinical features of TSC and discuss the differential diagnosis of oncocytic renal tumours.
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spelling pubmed-99997032023-04-21 Eosinophilic Solid and Cystic Renal Cell Carcinoma: From Unclassified to Classified, A Case Report Sharma, Rashim Thirunavukkarasu, Balamurugan Elhence, Poonam Rodha, Mahaveer Singh Sureka, Binit Turk Patoloji Derg Case Report Eosinophilic solid and cystic renal cell carcinoma (ESC RCC) is a novel tumour with unique morphological and immunohistochemical features. It is a recently described entity after the 2016 World Health Organization Classification of Tumours of the Urinary System and Male Genital Organs and is characterised by a solid cystic tumour composed of polygonal cells with voluminous eosinophilic cytoplasm and CK20 positivity. This tumour has uncertain malignant potential and also has an association with tuberous sclerosis complex (TSC). Sarcomatoid differentiation has not been reported in ESC RCC till now. ESC RCC poses a diagnostic challenge as many eosinophilic/oncocytic renal tumours are included in the differentials. We present a case of ESC RCC with sarcomatoid differentiation in an elderly female without any clinical features of TSC and discuss the differential diagnosis of oncocytic renal tumours. Federation of Turkish Pathology Societies 2022-01-21 /pmc/articles/PMC9999703/ /pubmed/34514562 http://dx.doi.org/10.5146/tjpath.2021.01531 Text en Copyright © 2022 The Author(s). https://creativecommons.org/licenses/by/4.0/This is an open-access article published by Federation of Turkish Pathology Societies under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is properly cited. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Case Report
Sharma, Rashim
Thirunavukkarasu, Balamurugan
Elhence, Poonam
Rodha, Mahaveer Singh
Sureka, Binit
Eosinophilic Solid and Cystic Renal Cell Carcinoma: From Unclassified to Classified, A Case Report
title Eosinophilic Solid and Cystic Renal Cell Carcinoma: From Unclassified to Classified, A Case Report
title_full Eosinophilic Solid and Cystic Renal Cell Carcinoma: From Unclassified to Classified, A Case Report
title_fullStr Eosinophilic Solid and Cystic Renal Cell Carcinoma: From Unclassified to Classified, A Case Report
title_full_unstemmed Eosinophilic Solid and Cystic Renal Cell Carcinoma: From Unclassified to Classified, A Case Report
title_short Eosinophilic Solid and Cystic Renal Cell Carcinoma: From Unclassified to Classified, A Case Report
title_sort eosinophilic solid and cystic renal cell carcinoma: from unclassified to classified, a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999703/
https://www.ncbi.nlm.nih.gov/pubmed/34514562
http://dx.doi.org/10.5146/tjpath.2021.01531
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AT elhencepoonam eosinophilicsolidandcysticrenalcellcarcinomafromunclassifiedtoclassifiedacasereport
AT rodhamahaveersingh eosinophilicsolidandcysticrenalcellcarcinomafromunclassifiedtoclassifiedacasereport
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