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  1. 1
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    The University College London/Medical Research Council/National Institute of Health Research-Health Technology Assessment PROMIS Trial: An Update
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    “…Cancer of any volume and any grade was detected in 34 of 54 (63%) patients. mp-MRI accuracy at detection of clinically significant cancer using University College London (UCL) definition 2 (any Gleason score of 4 or maximum cancer core length of ≥4 mm or both) showed sensitivity of 76%, specificity of 42%, positive predictive value of 38%, and negative predictive value of 79%. …”
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    The accuracy of multiparametric MRI in men with negative biopsy and elevated PSA level—Can it rule out clinically significant prostate cancer?
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    “…DESIGN, SETTING, AND PARTICIPANTS: PROMIS participants (n = 235) underwent mpMRI followed by a combined biopsy procedure at University College London Hospital, including 5-mm TPM as the reference standard. …”
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    False Positive Multiparametric Magnetic Resonance Imaging Phenotypes in the Biopsy-naïve Prostate: Are They Distinct from Significant Cancer-associated Lesions? Lessons from PROMIS [Image: see text] ()
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    “…SIMPLE SUMMARY: As we start to see the increased, routine, use of multiparametric magnetic resonance imaging (mpMRI) to inform prostate cancer diagnosis and image-guided biopsy, data collected from University College London Hospital describes the expected diagnostic outcomes of PSA and PSA Density in this pathway as well as the potential space remaining for novel biomarkers to further improve the pathway. …”
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    Evaluation of PSA and PSA Density in a Multiparametric Magnetic Resonance Imaging-Directed Diagnostic Pathway for Suspected Prostate Cancer: The INNOVATE Trial
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