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1por Osiyemi, Olayemi, Ajana, Faïza, Bisshop, Fiona, De Wit, Stéphane, Portilla, Joaquín, Routy, Jean-Pierre, Wyen, Christoph, Ait-Khaled, Mounir, Pappa, Keith, Wang, Ruolan, Leone, Peter, Wright, Jonathan, Wynne, Brian, van Wyk, Jean A, Aboud, Michael, Smith, Kimberly“…Non-inferior virologic efficacy has been proven over 3 years in treatment-naive people living with HIV (PLWH) and 2 years in a stable switch setting. METHODS: TANGO, a randomized, open-label, non-inferiority study, evaluates efficacy and safety of switching to DTG/3TC in PLWH who are virologically suppressed ( > 6 months, no prior virologic failure [VF], no major NRTI/INSTI resistance) vs remaining on a 3- or 4-drug TAF-based regimen (TBR), stratified by baseline 3rd agent class. …”
Publicado 2021
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2por van Wyk, Jean, Ait-Khaled, Mounir, Santos, Jesus, Scholten, Stefan, Wohlfeiler, Michael, Ajana, Faïza, Jones, Bryn, Nascimento, Maria-Claudia, Tenorio, Allan R., Smith, Don E., Wright, Jonathan, Wynne, Brian“…In TANGO, switching to dolutegravir/lamivudine was noninferior at 48 weeks to continuing 3-/4-drug tenofovir alafenamide–based regimens in virologically suppressed individuals with HIV-1. …”
Publicado 2021
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3por Wyk, Jean Van, Ajana, Faïza, Bisshop, Fiona, de Wit, Stéphane, Ait‐Khaled, Mounir, Wang, Ruolan, Wright, Jonathan, Aboud, Michael, Smith, Kimberly, Zajdenverg, RobertoEnlace del recurso
Publicado 2021
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4por van Wyk, Jean, Ajana, Faïza, Bisshop, Fiona, De Wit, Stéphane, Osiyemi, Olayemi, Portilla Sogorb, Joaquín, Routy, Jean-Pierre, Wyen, Christoph, Ait-Khaled, Mounir, Nascimento, Maria Claudia, Pappa, Keith A, Wang, Ruolan, Wright, Jonathan, Tenorio, Allan R, Wynne, Brian, Aboud, Michael, Gartland, Martin J, Smith, Kimberly Y“…We present efficacy and safety of switching to DTG/3TC in virologically suppressed individuals. METHODS: TANGO is an open-label, multicenter, phase 3 study that randomized adults (1:1, stratified by baseline third agent class) with HIV-1 RNA <50 copies/mL to switch to once-daily fixed-dose DTG/3TC or remain on a tenofovir alafenamide (TAF)–based regimen. …”
Publicado 2020
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5por Osiyemi, Olayemi, De Wit, Stéphane, Ajana, Faïza, Bisshop, Fiona, Portilla, Joaquín, Routy, Jean Pierre, Wyen, Christoph, Ait-Khaled, Mounir, Leone, Peter, Pappa, Keith A, Wang, Ruolan, Wright, Jonathan, George, Nisha, Wynne, Brian, Aboud, Michael, van Wyk, Jean, Smith, Kimberly Y“…METHODS: TANGO is a randomized (1:1, stratified by baseline third agent class), open-label, noninferiority phase 3 study. …”
Publicado 2022
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