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  1. 1
    “…OBJECTIVE: To compare central nervous system (CNS) outcomes in participants treated during acute HIV infection with standard combination antiretroviral therapy (cART) vs. cART plus integrase inhibitor and CCR5 antagonist (cART+). …”
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    Neurological Response to cART vs. cART plus Integrase Inhibitor and CCR5 Antagonist Initiated during Acute HIV
  2. 2
    “…OBJECTIVES: Cognitive impairment remains frequent in HIV, despite combination antiretroviral therapy (cART). Leading theories implicate peripheral monocyte HIV DNA reservoirs as a mechanism for spread of the virus to the brain. …”
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    HIV DNA Reservoir Increases Risk for Cognitive Disorders in cART-Naïve Patients
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    Correction: HIV DNA Reservoir Increases Risk for Cognitive Disorders in cART-Naïve Patients
  4. 4
    “…There was a marked divergence of HIV DNA values between the untreated and treated groups that occurred within the first 2 weeks of ART and increased with time. ART reduced total HIV DNA levels by 20-fold after 2 weeks and 316-fold after 3 years. …”
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    HIV DNA Set Point is Rapidly Established in Acute HIV Infection and Dramatically Reduced by Early ART()()
  5. 5
    “…RESULTS: HIV-positive participants, mean age 45 (SD 7.69) years received cART for a median of 12.1 years (interquartile range [IQR] 9.1–14.4). …”
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    HIV-associated cognitive performance and psychomotor impairment in a Thai cohort on long-term cART
  6. 6
    “…METHODS: Fifty HIV-infected, ART-naïve Thai adults with CD4 T cell count ≤350cells/µL and starting ART were evaluated over 96 weeks (ClinicalTrials.gov identifier NCT01296373). …”
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    Restoration of CMV-Specific-CD4 T Cells with ART Occurs Early and Is Greater in Those with More Advanced Immunodeficiency
  7. 7
    “…Starting antiretroviral therapy (ART) in Fiebig 1 acute HIV infection limits the size of viral reservoirs in lymphoid tissues, but does not impact time to virus rebound during a treatment interruption. …”
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    Paradoxically Greater Persistence of HIV RNA-Positive Cells in Lymphoid Tissue When ART Is Initiated in the Earliest Stage of Infection
  8. 8
    “…Furthermore, early initiation of ART in FI/II fully reversed the initially observed mucosal and systemic immune-activation. …”
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    Initiation of ART during Early Acute HIV Infection Preserves Mucosal Th17 Function and Reverses HIV-Related Immune Activation
  9. 9
    “…With limited funds to provide ART to millions of patients worldwide, there is a need for alternative ways to scale up ART in resource limited settings. …”
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    Generic and low dose antiretroviral therapy in adults and children: implication for scaling up treatment in resource limited settings
  10. 10
    “…METHODS: Fifteen participants who initiated ART at AHI were randomized to vorinostat/hydroxychloroquine/maraviroc (VHM) plus ART (n ​= ​10) or ART alone (n ​= ​5). …”
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    A randomized trial of vorinostat with treatment interruption after initiating antiretroviral therapy during acute HIV-1 infection
  11. 11
    “…INTRODUCTION: Antiretroviral therapy (ART) is recommended in perinatally HIV‐infected (PHIV) infants immediately upon diagnosis. …”
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    Low risk of neurodevelopmental impairment among perinatally acquired HIV‐infected preschool children who received early antiretroviral treatment in Thailand
  12. 12
    “…Early initiation of antiretroviral therapy (ART) in acute HIV infection (AHI) is effective at limiting seeding of the HIV viral reservoir, but little is known about how the resultant decreased antigen load affects long-term Ab development after ART. …”
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    Anti-HIV antibody development up to 1 year after antiretroviral therapy initiation in acute HIV infection
  13. 13
    “…OBJECTIVE: To determine the relationship between monocyte subsets, the sCD163 monocyte activation marker, and neuropsychological performance among perinatally HIV-infected children initiating antiretroviral therapy (ART). METHODS: ART-naïve children from the PREDICT study were categorised into two groups: those on ART for ≥24 weeks (ART group, n=201) and those untreated (no ART group, n=79). …”
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    Soluble CD163 and monocyte populations in response to antiretroviral therapy and in relationship with neuropsychological testing among HIV-infected children
  14. 14
    “…Although HIV-specific CD8(+) T cells become dysfunctional without treatment, antiretroviral therapy (ART) partially restores their function. However, the extent of this recovery under long-term ART is less understood. …”
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    Long-term antiretroviral therapy initiated in acute HIV infection prevents residual dysfunction of HIV-specific CD8(+) T cells
  15. 15
    “…INTRODUCTION: Up to 30% of individuals treated with antiretroviral therapy (ART) during chronic HIV fail to recover CD4 counts to >500 cells/mm(3) despite plasma viral suppression. …”
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    Determinants of suboptimal CD4(+) T cell recovery after antiretroviral therapy initiation in a prospective cohort of acute HIV‐1 infection
  16. 16
    “…METHODS: We conducted a cross-sectional assessment of markers for carbohydrate, lipid, bone metabolism, inflammation and coagulation in HIV-positive adolescents on ART and HC (n=37) versus on ART only (n=51) in Thailand. …”
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    Carbohydrate, lipid, bone and inflammatory markers in HIV-positive adolescents on antiretroviral therapy and hormonal contraception
  17. 17
    “…RESULTS: Among 375 participants with pre-ART CD4 T cell counts < 200 ​cells/mm(3), the prevalence of SIR was 39.7%, 19.7% and 7.7% at years 1, 2 and 3 after starting ART, respectively. …”
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    Characteristics of suboptimal immune response after initiating antiretroviral therapy among people living with HIV with a pre-treatment CD4 T cell count <200 ​cells/mm(3) in Thailand()
  18. 18
    “…All accepted the randomized arm; however, 3 in arm 1 stopped ART and 1 in arm 2 refused to start ART. Ten/19 (53%) in arm 2 started ART. …”
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    A feasibility study of immediate versus deferred antiretroviral therapy in children with HIV infection
  19. 19
    “…Introduction: Antiretroviral treatment (ART) reduces HIV transmission. Despite increased ART coverage, incidence remains high among men who have sex with men (MSM) in many places. …”
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    Acute HIV infection detection and immediate treatment estimated to reduce transmission by 89% among men who have sex with men in Bangkok
  20. 20
    “…OBJECTIVE: We examined individual differences in CD4/CD8 T-cell ratio trajectories and associated risk profiles from acute HIV infection (AHI) through 144 weeks of antiretroviral therapy (ART) using a data-driven approach. METHODS: A total of 483 AHI participants began ART during Fiebig I–V and completed follow-up evaluations for 144 weeks. …”
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    Individual Differences in CD4/CD8 T-Cell Ratio Trajectories and Associated Risk Profiles Modeled From Acute HIV Infection
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