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    “…Patient safety events, including HAI, may differ across racial and ethnic groups and negatively impact health outcomes. [Figure: see text] [Figure: see text] [Figure: see text] DISCLOSURES: Sonali D. …”
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    2042. Impact of the COVID-19 Pandemic on Healthcare-Associated Infections (HAI) by Race and Ethnicity in a Large Network of Community Hospitals: A Call to Action
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    “…[Figure: see text] RESULTS: Of 219,338 encounters, 3392 charts were included and reviewed; 723 (21.3%) patients met criteria for UTI. …”
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    2818. Investigating Urinalysis Criteria that Predict UTI: Impact of age, sex, and urine culture thresholds
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    “…Similar trends were seen in SR models for CLABSI and CAUTI (Figures 1, 2 and Table 1). While overall CDIs decreased significantly from 3.5 to 2.5/10,000 patient days in the pandemic period (P< 0.001), SR model showed increasing pandemic trend change (Figure 3). …”
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    172. Impact of COVID-19 Pandemic on Healthcare-associated Infections (HAIs) in a Large Network of Hospitals
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    “…[Figure: see text] Conditional logistic regression model constructed via backward elimination to determine independent predictors and confounders of MABC acquisition Figure 1. …”
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    1997. Risk Factors and Outcomes of Mycobacterium abscessus Complex (MABC) Acquisition after Lung Transplantation
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    “…Treatment choice had no significant effect on total C. difficile colony counts across sites sampled over time (Figure 2). However, both vancomycin (P = 0.001) and fidaxomicin (P = 0.01) were associated with lower proportions of positive environmental cultures than metronidazole (Figure 3). …”
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    841. Implications of C. difficile Treatment on Environmental Contamination: A Randomized Controlled Trial with Microbiologic, Environmental, and Molecular Outcomes
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    “…K. pneumoniae was the most common species (Figure 1). Mapping of patients revealed probable direct and indirect transmission between patients in multiple hospital units (Figure 2). three patients who were non-sequentially admitted to the same ICU room over a 12-week span acquired KPC K. pneumoniae (Figure 2). …”
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    1251. Contaminated Sinks May be an Environmental Source for Serial Transmission of Carbapenem-Resistant Enterobacteriaceae (CRE) to ICU Patients
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    “…Median total room CFU was 7,918 (IQR 2,939–18,855) (Figure 1). Median CFU for the examination area, patient area and physician areas were 2090 (537–10508), 1524 (573–4605) and 960 (371–2183), respectively (Figure 2). …”
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    1212. Environmental Contamination Characterization of Two Outpatient Clinics
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    “…Only one sample, obtained from the bedrails of a symptomatic patient with diarrhea and a fever on day 3, was culture-positive (Figure 2). Table 1. Patient Characteristics [Image: see text] Figure 1. …”
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    431. SARS-CoV-2 Environmental Contamination in Hospitalized COVID-19 Patients’ Rooms
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    “…The high NPV >=0.90 of pyuria was maintained among most patient age and sex subgroups with the exception of females ≥65 and patients with indwelling catheters (Table 2). [Figure: see text] [Figure: see text] CONCLUSION: UA parameters should be leveraged for their NPV instead of sensitivity, when used as a part of diagnostic workup. …”
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    190. Performance of urinalysis parameters in predicting significant bacteriuria: Making the case for a population-specific approach to diagnostic stewardship
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    “…Figure 1. Estimated Approvals per Week [Image: see text] Figure 2. …”
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    224. Effect of Easing Overnight Restrictions on Antimicrobial Starts
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    “…RESULTS: The proportion of I-PDX was highly variable among hospitals, with a system-wide median of 37.27% (range 23.48 - 43.32) (Figure 1). Using DOT / 1,000 patient days for 1 year, Hospital A was the lowest in the system and hospital H was the highest (Figure 2). …”
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    935. Antibiotic Use (AU) Adjustment by Infection-Related Patient Volume Across a Health System
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    “…RESULTS: Sepsis was present in 302/577 (52%) hospitalizations ending in death or discharge to hospice and was the immediate cause of death in 199 cases (35%) (Figure 1A). Underlying causes of death in sepsis patients included solid cancer (21%) and chronic heart disease (15%), and hematologic cancer (10%) (Figure 1B). …”
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    110. The Burden and Preventability of Sepsis-Associated Mortality in 6 US Acute Care Hospitals
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    “…[Figure: see text] Incidence rates of NTM episodes observed from 2014-2020 at a 7-hospital cohort. …”
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    1868. Epidemiology of Healthcare Facility-Associated Nontuberculous Mycobacteria at a 10-Hospital Network
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    “…We then used these values to estimate the number of SSIs that could have been prevented by SPC, and corresponding deaths avoided and cost savings (Figure 1). RESULTS: Optimized charts detected 96% of the outbreaks earlier than traditional surveillance, while pilot study and common practice charts did so only 65% (58%) of the time (Figure 2). …”
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    1232. Potential Health and Cost Outcomes of Optimized Statistical Process Control Use for Surgical Site Infection Surveillance
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    “…Facility-wide AU was increasing during the first year of network entry and then began decreasing by 0.2% per month (P = 0.01, figure). Fluoroquinolone use was stagnant in year one and then decreased by 1.5% per month (P ≤ 0.001, figure). …”
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    2089. Effect of the Duke Antimicrobial Stewardship Outreach Network (DASON): A Multi-Center Time Series Analysis
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    “…Models strongly predicted the binary outcome, with AUCs ranging from 0.70 to 0.95 depending on the stratum (Figure A, B). The addition of more complex variables increased accuracy (Figure Model Tiers 1–4). …”
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    1018. Using prediction modeling to inform risk-adjustment strategy for hospital antimicrobial use: Can we predict who gets an inpatient antimicrobial?
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    “…There was a transient decline in surgical cases beginning in March 2020, reaching a nadir of 185 cases in April, followed by a return to pre-pandemic volume by June (figure 1). Overall and procedure-specific SSI PRs were not significantly different in the COVID-19 period relative to the pre-pandemic period (total PR per 100 cases 0.96 and 0.97, respectively, figure 2). …”
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    811. Impact of the COVID-19 Pandemic on Surgical Volume and Surgical Site Infections (SSI) in a Large Network of Community Hospitals
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    “…Rates for other common antibiotics did not increase after the warning, either overall (figure) or in any subgroup. Results were robust to sensitivity analysis for lagged effects. …”
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    1863. Antibiotic Prescribing Before and After an FDA Boxed Warning on Fluoroquinolones in 2016
  19. 19
    “…CL, center line; LCL, lower control limit; UCL, upper control limit. [Image: see text] Figure 2. Use of a moving average statistical process control (SPC) chart for early detection of a pseudo-outbreak of Mycobacterium avium complex (MAC) that occurred at a bronchoscopy suite. …”
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    877. Use of Statistical Process Control Charts for Early Detection of Healthcare Facility-Associated Nontuberculous Mycobacterial Outbreaks
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    “…A 23-item safety check excluded patients with ongoing signs of infection, concerning or inadequate microbiologic data, or high-risk conditions (Figure 1). Eligible patients were randomized to the opt-out protocol vs. usual care. …”
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    14. Effects of an Opt-Out Protocol for Antibiotic De-escalation among Selected Patients with Suspected Sepsis: The DETOURS Trial
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