Mostrando 1 - 20 Resultados de 23 Para Buscar '"Drosophila melanogaster"', tiempo de consulta: 0.28s Limitar resultados
  1. 1
    “…To answer these questions we used Drosophila melanogaster, because its chemosensory systems are well characterized and both the genotype and environment can be controlled precisely. …”
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    Plasticity of the Chemoreceptor Repertoire in Drosophila melanogaster
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    por Mackay, Trudy F. C., Richards, Stephen, Stone, Eric A., Barbadilla, Antonio, Ayroles, Julien F., Zhu, Dianhui, Casillas, Sònia, Han, Yi, Magwire, Michael M., Cridland, Julie M., Richardson, Mark F., Anholt, Robert R. H., Barrón, Maite, Bess, Crystal, Blankenburg, Kerstin Petra, Carbone, Mary Anna, Castellano, David, Chaboub, Lesley, Duncan, Laura, Harris, Zeke, Javaid, Mehwish, Jayaseelan, Joy Christina, Jhangiani, Shalini N., Jordan, Katherine W., Lara, Fremiet, Lawrence, Faye, Lee, Sandra L., Librado, Pablo, Linheiro, Raquel S., Lyman, Richard F., Mackey, Aaron J., Munidasa, Mala, Muzny, Donna Marie, Nazareth, Lynne, Newsham, Irene, Perales, Lora, Pu, Ling-Ling, Qu, Carson, Ràmia, Miquel, Reid, Jeffrey G., Rollmann, Stephanie M., Rozas, Julio, Saada, Nehad, Turlapati, Lavanya, Worley, Kim C., Wu, Yuan-Qing, Yamamoto, Akihiko, Zhu, Yiming, Bergman, Casey M., Thornton, Kevin R., Mittelman, David, Gibbs, Richard A.
    Publicado 2012
    “…Here, we describe the Drosophila melanogaster Genetic Reference Panel (DGRP), a community resource for analysis of population genomics and quantitative traits. …”
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    The Drosophila melanogaster Genetic Reference Panel
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    Systems Genetics of Complex Traits in Drosophila melanogaster
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    “…Whereas neural mechanisms that mediate the effects of these drugs are well-characterized, genetic factors that account for individual variation in susceptibility to substance abuse and addiction remain largely unknown. Drosophila melanogaster can serve as a translational model for studies on substance abuse, since flies have a dopamine transporter that can bind cocaine and methamphetamine, and exposure to these compounds elicits effects similar to those observed in people, suggesting conserved evolutionary mechanisms underlying drug responses. …”
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    Genetics of cocaine and methamphetamine consumption and preference in Drosophila melanogaster
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    “…Using whole-genome quantitative gene expression as a model, here we study how the genetic architecture of regulatory variation in gene expression changed in a population of fully sequenced inbred Drosophila melanogaster strains when flies developed in different environments (25 °C and 18 °C). …”
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    Genotype by environment interaction for gene expression in Drosophila melanogaster
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    “…Here, we report that RNAi knockdown of Obp56h gene expression in Drosophila melanogaster enhances mating behavior by reducing courtship latency. …”
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    Obp56h Modulates Mating Behavior in Drosophila melanogaster
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    “…Here, we used RNA interference in Drosophila melanogaster to reduce expression of six genes (brm, osa, Snr1, SMC1, SMC3, vtd) orthologous to human genes associated with SSRIDDs and CdLS. …”
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    Genetic and Genomic Analyses of Drosophila melanogaster Models of Chromatin Modification Disorders
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    “…Oxidative stress resistance is a quantitative trait with population variation attributable to the interplay between genetic and environmental factors. Drosophila melanogaster provides an ideal system to study the genetics of variation for resistance to oxidative stress. …”
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    Genome-Wide Association Analysis of Oxidative Stress Resistance in Drosophila melanogaster
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    “…To identify genes affecting sensitivity and resistance to ROS-induced locomotor decline, we assessed locomotion of aged flies of the sequenced, wild-derived lines from the Drosophila melanogaster Genetics Reference Panel on standard medium and following chronic exposure to medium supplemented with 3 mM menadione sodium bisulfite (MSB). …”
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    Genome-Wide Association for Sensitivity to Chronic Oxidative Stress in Drosophila melanogaster
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    “…However, the functions of many lncRNAs remain unknown. In Drosophila melanogaster, U snoRNA host gene 4 (Uhg4) encodes an antisense long noncoding RNA that is host to seven small nucleolar RNAs (snoRNAs). …”
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    Pleiotropic fitness effects of the lncRNA Uhg4 in Drosophila melanogaster
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    “…We used Drosophila melanogaster to map the genetic basis of naturally occurring variation in voluntary consumption of cocaine and methamphetamine. …”
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    Genetic basis of variation in cocaine and methamphetamine consumption in outbred populations of Drosophila melanogaster
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    Natural genetic variation in a dopamine receptor is associated with variation in female fertility in Drosophila melanogaster
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    “…Thus, exposure to ethanol during development of Drosophila melanogaster might serve as a genetic model for translational studies on fetal alcohol spectrum disorder.…”
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    A Cyclin E Centered Genetic Network Contributes to Alcohol-Induced Variation in Drosophila Development
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    “…RESULTS: We used 96 sequenced, wild-derived inbred lines from the Drosophila melanogaster Genetic Reference Panel (DGRP) to profile genome-wide transcript abundances in young adult flies that developed on ethanol-supplemented medium or standard culture medium. …”
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    Modulation of the Drosophila transcriptome by developmental exposure to alcohol
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    “…We assessed variation in genome-wide gene expression and four fitness-related phenotypes of an outbred Drosophila melanogaster population under 20 different physiological, social, nutritional, chemical, and physical environments; and we compared the phenotypically plastic transcripts to genetically variable transcripts in a single environment. …”
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    Phenotypic Plasticity of the Drosophila Transcriptome
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    “…Defects in lipolysis can be modeled in Drosophila melanogaster through genetic manipulations of brummer (bmm), which encodes a triglyceride lipase orthologous to mammalian Adipose Triglyceride Lipase. …”
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    Physiological and metabolomic consequences of reduced expression of the Drosophila brummer triglyceride Lipase
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    “…Longevity varies among individuals, but how natural genetic variation contributes to variation in lifespan is poorly understood. Drosophila melanogaster presents an advantageous model system to explore the genetic underpinnings of longevity, since its generation time is brief and both the genetic background and rearing environment can be precisely controlled. …”
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    Regulation of Drosophila Lifespan by bellwether Promoter Alleles
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    “…Studies on genetic variation in susceptibility to environmental toxins are challenging in human populations, due to the variety of clinical symptoms and difficulty in determining which symptoms causally result from toxic exposure; uncontrolled environments, often with exposure to multiple toxicants; and difficulty in relating phenotypic effect size to toxic dose, especially when symptoms become manifest with a substantial time lag. Drosophila melanogaster is a powerful model that enables genome-wide studies for the identification of allelic variants that contribute to variation in susceptibility to environmental toxins, since the genetic background, environmental rearing conditions and toxic exposure can be precisely controlled. …”
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    A Drosophila model for toxicogenomics: Genetic variation in susceptibility to heavy metal exposure
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    “…Here, we quantified variation in life span in males and females reared in 3 thermal environments for the sequenced, inbred lines of the Drosophila melanogaster Genetic Reference Panel (DGRP) and an advanced intercross outbred population derived from a subset of DGRP lines. …”
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    Context-dependent genetic architecture of Drosophila life span
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    “…To examine how genetic variation impacts MeHg tolerance, we assessed developmental tolerance to MeHg using the sequenced, inbred lines of the Drosophila melanogaster Genetic Reference Panel (DGRP). We found significant genetic variation in the effects of MeHg on development, measured by eclosion rate, giving a broad sense heritability of 0.86. …”
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    Genome-Wide Association Analysis of Tolerance to Methylmercury Toxicity in Drosophila Implicates Myogenic and Neuromuscular Developmental Pathways
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