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  1. 1
    “…In Enterobacteriaceae, susceptibility to C/T reached 92% in E. coli (Figure 1A), 91% in E. cloacae complex (Figure 1B) and 70% in K. pneumoniae (Figure 1C). …”
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    1592. In Vitro Activity of Ceftolozane/Tazobactam (C/T) Against Enterobacteriaceae and Pseudomonas aeruginosa Circulating in Chile
  2. 2
    “…A total of 8,157 S. aureus culture isolations were registered, from 5,384 events that occurred in 4,821 patients (Figure 1). Median age was 5 years (range 1-12). The most frequent infection source was blood (26.2%), followed by skin and soft tissue (18.4%). …”
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    1685. Epidemiological and microbiological characteristics of S. aureus pediatric infections in Colombia 2018-2022, a National Multicenter Study: Staphylored Colombia
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    “…Other portions of the bla operon include blaR and blaI (encoding the antibiotic sensor and transcriptional repressor, respectively) and the intergenic region with operator and promoter sequences (Figure 1). In BlaR, residue 293 mediates signal transduction, and the Z and R dyads in the intergenic region are the DNA-binding sites for BlaI (Figure 2). …”
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    199. Polymorphisms in Key Regulatory Regions of the bla operon Correlate with the Cefazolin Inoculum Effect in Methicillin-Susceptible Staphylococcus aureus (MSSA)
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    “…The published protocol of the nitrocefin test (Rincon et al., JCM, 2021) was modified as follows (Figure 2): instead of adding ampicillin from powder to BHI broth (150 ug/mL), ampicillin disks (10 ug) of 2 different brands (Oxoid and BD) were added to 1 mL of BHI broth of 2 different brands (Oxoid, BD) and incubated for 2 hours at room temperature with frequent shaking (Figure 3). …”
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    575. Optimization of a Nitrocefin-Based Rapid Test for the Detection of the Cefazolin Inoculum Effect (CzIE) in Methicillin-Susceptible Staphylococcus aureus
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    “…A Kaplan-Meier curve of all-cause 30-day mortality is in Figure 2 [Figure: see text] [Figure: see text] Desirability of outcome ranking at 30-days. …”
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    1029. Increased Mortality in Hospital-Onset Carbapenem-Resistant Enterobacterales Bloodstream Infections
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    “…One lost C. albicans colonization but had persistent C. glabrata colonization despite azole therapy, and another developed C. parapsilosis colonization despite azole and amphotericin administration. Figure 1. [Figure: see text] Results of serial stool samples tested for Candida colonization per individual patient. …”
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    806. Candida Gut Colonization in Critically Ill Patients
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    “…When assessing mortality according to specific MDRO type, VRE colonization was associated with in-hospital mortality (35% with VRE colonization vs. 14% without, p=0.02). Figure 1. [Figure: see text] Results of serial stool samples tested for target multi-drug resistant organisms in intensive care unit patients. …”
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    712. Dynamics of Colonization with Multi-Drug Resistant Organisms and Clinical Outcomes in Critically Ill Patients: A Prospective Cohort Study
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    “…We also performed whole-genome sequencing (WGS) in 104 MSSA isolates exhibiting and lacking the CzIE to compare the sequences of BlaZ, BlaR, and BlaI and classified them by allotypes (unique amino acid sequences) using ATCC29213 as reference. [Image: see text] Figure 2. In trans expression of blaZ genes from a CzIE+ strain (TX0117) and a CzIE- strain (ATCC29213) in RN4220 [Image: see text] Figure 3. …”
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    28. Regulation of the Staphylococcal β-lactamase Plays a Major Role in the cefazolin Inoculum Effect
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    “…Molecular clock analyses suggested all clades share a common ancestor with the divergence of the Chilean clades occurring earlier (Figure 2). Of note, analysis of heavy metal genes suggested the divergence between Chilean isolates was characterized by the loss of a mercury resistance gene cluster, which is present in an 88% of CON isolates, but only in 28% of SCL (Figure 2). …”
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    556. Phylogenomic Epidemiology of Methicillin-Resistant Staphylococcus aureus (MRSA) Chilean-Cordobes Clone in Latin America
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    “…RESULTS: The prevalence of resistance across all β-lactams tested increased in contemporary strains as compared with that of historical strains (Figure 1). Among important contemporary antipseudomonal antibiotics C/T, ATM, and CZA, resistance increased from 0%, 22%, and 5% to 15%, 44%, and 16%, respectively (Figure 1). …”
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    481. Evolution of Carbapenem-Resistant Pseudomonas aeruginosa (CR-PA) Genetic Lineages and Acquisition of β-Lactamase Enzymes
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    “…DAP-R was associated with mislocalization of PBPs to the sites of CM aberrations (Figure 2). Notably, LiaX and PBP5 were localized to the septum in DAP-S strains but redistributed away from septal areas upon development of DAP-R (Figure 3). …”
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    903. Resensitization to β-Lactams in Enterococci Depends on Penicillin-Binding Protein (PBP) Mislocalization and Is Mediated by a Single Protein That Modulates Cell Membrane (CM) Adaptation to Daptomycin (DAP)
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    “…The probability of a better DOOR outcome for a randomly selected MBL was 58% [95% CI: 48.2, 67.4], indicating no significant difference between the groups. [Figure: see text] [Figure: see text] Legend: Infection = categorization as infection or colonization. …”
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    229. Molecular and Clinical Epidemiology of Carbapenemase-Producing E. coli Isolates from Different Global Regions (CRACKLE-2)
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    “…In contrast, OG117ΔliaSΔmadS displayed no significant change in madG expression when exposed to bacitracin (Fig 2). [Figure: see text] CONCLUSION: In the absence of a functional MadS histidine-kinase there is still transcriptional upregulation of madG. …”
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    2182. Expression of the MadR regulon in Enterococcus faecalis OG117 is influenced by the presence of the LiaS Histidine Kinase of the LiaFSR pathway
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    “…Type III and VI secretion systems, were also found in all isolates resembling Bps from other parts of the world. [Image: see text] Figure 1. Maximum clade credibility tree of 82 genomes of Bps. …”
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    728. Genomic Characterization of Burkholderia pseudomallei Isolates in Colombia
  15. 15
    “…Most frequent MRSA clones are represented by colored sections. Figure 3. Maximum clade credibility tree from the molecular clock analysis of the 798 MRSA genomes. …”
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    666. Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus in Chile between 1999-2018
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    “…These 4 patients all had unsuccessful discharge combined with renal failure (n=2), and/or lack of clinical response (n=3). [Figure: see text] Desirability of outcome ranking (DOOR) analyses [Figure: see text] Shown are the percentages of patients in each group with a specific DOOR category outcome. …”
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    215. Shorter vs. Longer Duration of Treatment in Patients with Ceftriaxone-resistant and Ceftriaxone-susceptible Escherichia coli Bloodstream Infections
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    “…Here, we outline geographic variation and prevalence of TBDR mutations in the Prospective Observational Pseudomonas (POP) study. [Figure: see text] [Figure: see text] Black versus gray differentiates presence of either PiuA versus PiuD homologous proteins. …”
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    2163. Prevalence and geographic distribution of mutations in TonB-dependent receptors in the Prospective Observational Pseudomonas aeruginosa (PA) Study
  18. 18
    “…The attenuation effect of the mutant was abolished in pmk-1 knockout worms, which lack the ability to produce innate immune peptides (Fig 2C). Figure 1 [Image: see text] Figure 2 CONCLUSION: The MadRS system plays an important role in mediating resistance to AP both in vitro and in vivo. …”
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    27. The Membrane Antimicrobial Peptide Defense (MadRS) System Orchestrates Resistance Against Antibiotics and Host Innate Immune Peptides in enterococcus Faecalis
  19. 19
    “…ESBL Kpn was not recovered subsequent to the FMT. Figure 1 [Image: see text] Figure 2 [Image: see text] CONCLUSION: Oral FMT was used to successfully decolonize a woman with recurrent UTIs due to ESBL Kpn. …”
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    1694. Successful Gut Decolonization of Extended-Spectrum β-lactamase Producing Klebsiella pneumoniae Using Oral Lyophilized Fecal Microbiota Transplant (FMT) in a Woman with Recurrent Urinary Tract Infections
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    “…[Figure: see text] BALB/c mice infected with paired initial or relapsed GNB-BSI isolate. 50 mg/kg ertapenem added at 3 hours post infection (hpi). …”
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    224. Clinical Relevance of Antibiotic Tolerance in Recurrent Gram-negative Bloodstream Infections
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