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1“…BACKGROUND: Mathematical optimization aims to make a system or design as effective or functional as possible, computing the quality of the different alternatives using a mathematical model. …”
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2por Vilas, Carlos, Balsa-Canto, Eva, García, Maria-Sonia G, Banga, Julio R, Alonso, Antonio A“…Examples would include, the design of a chemical stimulation to maximize the amplitude of a given cellular signal or to achieve a desired pattern in pattern formation systems, etc. Such design problems can be mathematically formulated as dynamic optimization problems which are particularly challenging when the system is described by partial differential equations. …”
Publicado 2012
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3“…BACKGROUND: Mathematical models provide abstract representations of the information gained from experimental observations on the structure and function of a particular biological system. …”
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4“…Analysing the properties of a biological system through in silico experimentation requires a satisfactory mathematical representation of the system including accurate values of the model parameters. …”
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5“…Motivation: Mathematical models of complex biological systems usually consist of sets of differential equations which depend on several parameters which are not accessible to experimentation. …”
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6por Ligon, Thomas S, Fröhlich, Fabian, Chiş, Oana T, Banga, Julio R, Balsa-Canto, Eva, Hasenauer, Jan“…MOTIVATION: Mathematical modeling using ordinary differential equations is used in systems biology to improve the understanding of dynamic biological processes. …”
Publicado 2018
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7“…Summary: Mathematical modeling has a key role in systems biology. …”
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8por Balsa-Canto, Eva, Vilas, Carlos, López-Núñez, Alejandro, Mosquera-Fernández, Maruxa, Briandet, Romain, Cabo, Marta L., Vázquez, Carlos“…This work combines quantitative image analysis, cell counts, nutrient uptake data and mathematical modeling to provide a mechanistic insight into the dynamics of the structure of biofilms formed by L. monocytogenes L1A1 (serotype 1/2a) strain. …”
Publicado 2017
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