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1por Blum, Kenneth, Kazmi, Shan, Modestino, Edward J., Downs, Bill William, Bagchi, Debasis, Baron, David, McLaughlin, Thomas, Green, Richard, Jalali, Rehan, Thanos, Panayotis K., Elman, Igor, Badgaiyan, Rajendra D., Bowirrat, Abdalla, Gold, Mark S.“…The formulations are based on the results of the addiction risk severity (GARS) test. Based on both neurogenetic and epigenetic evidence, the test evaluates the presence of reward genes and risk alleles. …”
Publicado 2021
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2por Blum, Kenneth, Green, Richard, Smith, Jessica, Llanos-Gomez, Luis, Baron, David, Badgaiyan, Rajendra DEnlace del recurso
Publicado 2020
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3por Moran, Mark, Blum, Kenneth, Ponce, Jessica Valdez, Lott, Lisa, Gondré–Lewis, Marjorie C., Badgaiyan, Sampada, Brewer, Raymond, Downs, B. William, Fynman, Philip, Weingarten, Alexander, Cadet, Jean Lud, Smith, David E., Baron, David, Thanos, Panayotis K., Modestino, Edward J., Badgaiyan, Rajendra D., Elman, Igor, Gold, Mark S.“…Evaluation of pain clinic patients with the Genetic Addiction Risk Score (GARS) test and the Addiction Severity Index (ASI- Media Version V) revealed that GARS scores equal to or greater than 4 and 7 alleles significantly predicted drug and alcohol severity, respectively. …”
Publicado 2021
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4por Modestino, Edward Justin, Blum, Kenneth, Dennen, Catherine A., Downs, B. William, Bagchi, Debasis, Llanos-Gomez, Luis, Elman, Igor, Baron, David, Thanos, Panayotis K., Badgaiyan, Rajendra D., Braverman, Eric R., Gupta, Ashim, Gold, Mark S., Bowirrat, AbdallaEnlace del recurso
Publicado 2022
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5por Blum, Kenneth, Han, David, Gupta, Ashim, Baron, David, Braverman, Eric R., Dennen, Catherine A., Kazmi, Shan, Llanos-Gomez, Luis, Badgaiyan, Rajendra D., Elman, Igor, Thanos, Panayotis K., Downs, Bill W., Bagchi, Debasis, Gondre-Lewis, Marjorie C., Gold, Mark S., Bowirrat, Abdalla“…While most of the research related to GARS is derived from our laboratory, we are encouraging more independent research to confirm our findings.…”
Publicado 2022
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6por Gupta, Ashim, Bowirrat, Abdalla, Gomez, Luis Llanos, Baron, David, Elman, Igor, Giordano, John, Jalali, Rehan, Badgaiyan, Rajendra D., Modestino, Edward J., Gold, Mark S., Braverman, Eric R., Bajaj, Anish, Blum, Kenneth“…The GARS test results identify high-risk for both drug and alcohol, and H-Wave can be initiated to treat pain instead of opioids. …”
Publicado 2022
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7por Blum, Kenneth, Brodie, Mark S., Pandey, Subhash C., Cadet, Jean Lud, Gupta, Ashim, Elman, Igor, Thanos, Panayotis K., Gondre-Lewis, Marjorie C., Baron, David, Kazmi, Shan, Bowirrat, Abdalla, Febo, Marcelo, Badgaiyan, Rajendra D., Braverman, Eric R., Dennen, Catherine A., Gold, Mark S.“…We present a hypothesis that identification of KCNK13 and RASGRF2 genes’ risk polymorphism, coupled with genetic addiction risk score (GARS)-guided precision pro-dopamine regulation, will mitigate binge alcohol drinking. …”
Publicado 2022
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8por Ceccanti, Mauro, Blum, Kenneth, Bowirrat, Abdalla, Dennen, Catherine A., Braverman, Eric R., Baron, David, Mclaughlin, Thomas, Giordano, John, Gupta, Ashim, Downs, Bernard W., Bagchi, Debasis, Barh, Debmalya, Elman, Igor, Thanos, Panayotis K., Badgaiyan, Rajendra D., Edwards, Drew, Gold, Mark S.“…Therefore, based on this extensive literature and additional research, this team of coauthors suggests that, in the future, in addition to the current nonpharmacological therapies, patients with opioid-induced NAS should undergo genetic assessment (i.e., the genetic addiction risk severity (GARS) test), which can subsequently be used to guide DNA-directed precision amino-acid enkephalinase inhibition (KB220) therapy as a frontline modality instead of potent opioids.…”
Publicado 2022
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9por Thanos, Panayotis K., Hanna, Colin, Mihalkovic, Abrianna, Hoffman, Aaron B., Posner, Alan R., Busch, John, Smith, Caroline, Badgaiyan, Rajendra D., Blum, Kenneth, Baron, David, Mastrandrea, Lucy D., Quattrin, Teresa“…Of the 11 risk alleles identified by GARS, the DRD4 risk allele (rs1800955), was significantly correlated with change in weight and BMI six months post-surgery. …”
Publicado 2023
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10por Dennen, Catherine A., Blum, Kenneth, Bowirrat, Abdalla, Thanos, Panayotis K., Elman, Igor, Ceccanti, Mauro, Badgaiyan, Rajendra D., McLaughlin, Thomas, Gupta, Ashim, Bajaj, Anish, Baron, David, Downs, B. William, Bagchi, Debasis, Gold, Mark S.“…This case series presents the novel genetic addiction risk score (GARS), which shows a high prevalence of polymorphic risk alleles of reward genes in a nuclear family with multiple reward deficiency syndrome (RDS) behavioral issues expressing a hypodopaminergic antecedent. …”
Publicado 2022
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11por Blum, Kenneth, Han, David, Bowirrat, Abdalla, Downs, Bernard William, Bagchi, Debasis, Thanos, Panayotis K., Baron, David, Braverman, Eric R., Dennen, Catherine A., Gupta, Ashim, Elman, Igor, Badgaiyan, Rajendra D., Llanos-Gomez, Luis, Khalsa, Jag, Barh, Debmalya, McLaughlin, Thomas, Gold, Mark S.“…To develop an accurate test to help identify those at risk for at least alcohol use disorder (AUD), a subset of reward deficiency syndrome (RDS), Blum’s group developed the genetic addiction risk severity (GARS) test, consisting of ten genes and eleven associated risk alleles. …”
Publicado 2022
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12Reward Deficiency Syndrome (RDS): A Cytoarchitectural Common Neurobiological Trait of All Addictionspor Blum, Kenneth, Bowirrat, Abdalla, Braverman, Eric R., Baron, David, Cadet, Jean Lud, Kazmi, Shan, Elman, Igor, Thanos, Panyotis K., Badgaiyan, Rajendra D., Downs, William B., Bagchi, Debasis, Llanos-Gomez, Luis, Gold, Mark S.“…Taking a Genetic Addiction Risk Severity (GARS) test combined with a the KB220Z semi-customized nutrigenomic supplement effectively restores dopamine homeostasis (WC 199).…”
Publicado 2021
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13por Blum, Kenneth, Thanos, Panayotis K, Hanna, Colin, Gold, Mark S, Baron, David, Elman, Igor“…Several from Blum et al showed the clinical relevance of the Genetic Addiction Risk Severity (GARS) test in identifying risk for reward deficiency behaviors in cohorts from polysubstance abuse and pain clinics, post-surgical bariatrics, and DWI offenders facing prison time. …”
Publicado 2023
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14por Dennen A., Catherine, Blum, Kenneth, Braverman R., Eric, Bowirrat, Abdalla, Gold, Marks, Elman, Igor, Thanos K., Panayotis, Baron, David, Gupta, Ashim, Edwards, Drew, Badgaiyan D., Rajendra“…Screening for preaddiction could be achieved through genetic testing (i.e., the genetic addiction risk severity (GARS) test) and/or through other neuropsychiatric testing (i.e., Memory (CNSVS), Attention (TOVA), Neuropsychiatric (MCMI-III), Neurological Imaging (qEEG/P300/EP)). …”
Publicado 2023
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15por Blum, Kenneth, Bowirrat, Abdalla, Braverman, Eric R, Dennen, Catherine, Zeine, Foojan, Jafari, Nicole, Sunder, Keerthy, Thanos, Panayotis K., Baron, David, Barh, Debmayla, Gupta, Ashim, Bagchi, Debasis, Gold, Mark S, Badgaiyan, Rajendra D.“…The development of the Genetic Addiction Risk Severity (GARS) test, Blum’s group believes that this type of testing should be the “standard of care” following additional studies. …”
Publicado 2023
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16por Blum, Kenneth, Bowirrat, Abdala, Elman, Igor, Baron, David, Thanos, Panayotis K., Gold, Mark S, Hanna, Colin, Makale, Milan T., Sunder, Keerthy, Jafari, Nicole, Zeine, Foojan, Murphy, Kevin T., Makale, Miles, Badgaiyan, Rajendra D.“…Several from Blum et al. showed the clinical relevance of the Genetic Addiction Risk Severity (GARS) test in identifying risk for reward deficiency behaviors in cohorts from polysubstance and pain clinics, post-surgical bariatrics, and DWI offenders facing prison time. …”
Publicado 2023
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17por Blum, Kenneth, Steinberg, Bruce, Gondre-Lewis, Marjorie C, Baron, David, Modestino, Edward J, Badgaiyan, Rajendra D, Downs, B William, Bagchi, Debasis, Brewer, Raymond, McLaughlin, Thomas, Bowirrat, Abdalla, Gold, Mark“…This approach includes 1) using the Genetic Addiction Risk Severity (GARS, a 10 candidate polymorphic gene panel shown to predict ASI-alcohol and drug severity) to assess early pre-disposition to substance use disorder; 2) using a validated reward deficiency syndrome (RDS) questionnaire; 3) utilization of the Comprehensive Analysis of Reported Drugs (CARD™) to assess treatment compliance and abstinence from illicit drugs during treatment, and, importantly; 4) utilization of a “Pro-dopamine regulator (KB220)” (via IV or oral [KB220Z] delivery systems) to optimize gene expression, restore the balance of the Brain Reward Cascade’s neurotransmitter systems and prevent relapse by induction of dopamine homeostasis, and; 5) utilization of targeted DNA polymorphic reward genes to direct mRNA genetic expression profiling during the treatment process. …”
Publicado 2021
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18por Blum, Kenneth, Dennen, Catherine A., Elman, Igor, Bowirrat, Abdalla, Thanos, Panayotis K., Badgaiyan, Rajendra D., Downs, B. William, Bagchi, Debasis, Baron, David, Braverman, Eric R., Gupta, Ashim, Green, Richard, McLaughlin, Thomas, Barh, Debmalya, Gold, Mark S.“…Epigenetic repair of hypodopaminergia, the causative basis of addictive behaviors, may involve precision DNA-guided therapy achieved by combining the Genetic Addiction Risk Severity (GARS) test with a researched neutraceutical having a number of variant names, including KB220Z. …”
Publicado 2022
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19por Blum, Kenneth, Gondré-Lewis, Marjorie, Steinberg1, Bruce, Elman, Igor, Baron, David, Modestino, Edward J, Badgaiyan, Rajendra D, Gold, Mark S“…Application of genetic addiction risk (GARS™) testing and pro-dopamine regulation (KB220) should be considered along with other promising technologies including cognitive behavioral therapy, mind fullness, brain spotting and trauma therapy. …”
Publicado 2018
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