Mostrando 1 - 20 Resultados de 32 Para Buscar '"The OA"', tiempo de consulta: 0.31s Limitar resultados
  1. 1
    “…To evaluate the influence of mitochondrial DNA haplogroups on the risk of knee OA in terms of their interaction with obesity, in a population from Mexico. …”
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    mtDNA haplogroup A enhances the effect of obesity on the risk of knee OA in a Mexican population
  2. 2
    “…Osteoarthritis (OA) remains a prevalent chronic disease without effective prevention and treatment. …”
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    Amentadione from the Alga Cystoseira usneoides as a Novel Osteoarthritis Protective Agent in an Ex Vivo Co-Culture OA Model
  3. 3
    “…DESIGN: Multiple reaction monitoring-mass spectrometry (MRM/MS) was applied to explore the potential phospholipidomic differences in the SF of knee OA patients (n ​= ​15) (subclassified into early- and late-stage OA) and non-OA controls (n ​= ​4). …”
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    Targeted phospholipidomic analysis of synovial fluid as a tool for osteoarthritis deep phenotyping
  4. 4
    “…Our results describe the differences between the mitochondrial protein profiles of normal and OA chondrocytes, demonstrating that mitochondrial dysregulation occurs in cartilage cells during OA and highlighting redox imbalance as a key factor in OA pathogenesis.…”
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    Mitochondrial Dysregulation of Osteoarthritic Human Articular Chondrocytes Analyzed by Proteomics: A Decrease in Mitochondrial Superoxide Dismutase Points to a Redox Imbalance
  5. 5
    “…Osteoarthritis (OA) is the most frequent joint disease; however, the etiopathogenesis is still unclear. …”
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    Impaired Metabolic Flexibility in the Osteoarthritis Process: A Study on Transmitochondrial Cybrids
  6. 6
    “…Objective: To assess a mitochondrion-related phenotype in patients with osteoarthritis (OA). Methods: Serum levels of the following OA-related biomarkers: matrix metalloproteinase-1 (MMP-1); MMP-3; MMP-13; myeloperoxidase (MPO); a peptide of the alpha-helical region of type II collagen, Coll2-1, and its nitrated form Coll2-1NO(2); a C-terminal neoepitope generated by the collagenase-mediated cleavage of collagen type II triple helix, C2C; the C-propeptide of collagen type II, CPII; hyaluronic acid (HA); human cartilage glycoprotein 39, YKL-40; cartilage oligomeric matrix protein; and cathepsin K were analyzed in 48 OA patients and 52 healthy controls carrying the haplogroups H and J. …”
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    Mitochondrial Haplogroups Define Two Phenotypes of Osteoarthritis
  7. 7
    “…Osteoarthritis (OA) is the most prevalent rheumatic pathology. However, OA is not simply a process of wear and tear affecting articular cartilage but rather a disease of the entire joint. …”
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    An Atlas of the Knee Joint Proteins and Their Role in Osteoarthritis Defined by Literature Mining
  8. 8
    “…OBJECTIVE: Axial osteoarthritis (OA) is a common cause of back and neck pain, however, few studies have examined its prevalence. …”
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    Prevalence of symptomatic axial osteoarthritis phenotypes in Spain and associated socio-demographic, anthropometric, and lifestyle variables
  9. 9
    “…Our objective was to identify molecules to prevent OA by regulating chondrocyte senescence and autophagy. …”
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    Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy
  10. 10
    “…Currently there are no sufficiently sensitive biomarkers able to reflect changes in joint remodelling during osteoarthritis (OA). In this work, we took an affinity proteomic approach to profile serum samples for proteins that could serve as indicators for the diagnosis of radiographic knee OA. …”
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    Discovery of circulating proteins associated to knee radiographic osteoarthritis
  11. 11
    “…Osteoarthritis (OA) is a chronic degenerative joint disease, being the main cause of laboral inability. …”
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    Association of accelerated dynamics of telomere sequence loss in peripheral blood leukocytes with incident knee osteoarthritis in Osteoarthritis Initiative cohort
  12. 12
    “…Osteoarthritis (OA) is a heterogenous, complex disease affecting the integrity of diarthrodial joints that, despite its high prevalence worldwide, lacks effective treatment. …”
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    Epigenetics as a Therapeutic Target in Osteoarthritis
  13. 13
    “…Osteoarthritis (OA) is the most common musculoskeletal disorder causing a great disability and a reduction in the quality of life. …”
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    Proteomic Analysis of Synovial Fibroblasts and Articular Chondrocytes Co-Cultures Reveals Valuable VIP-Modulated Inflammatory and Degradative Proteins in Osteoarthritis
  14. 14
    “…Different findings indicate that type 2 diabetes is an independent risk factor for osteoarthritis (OA). However, the mechanisms underlying the connection between both diseases remain unclear. …”
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    Reduced Levels of H(2)S in Diabetes-Associated Osteoarthritis Are Linked to Hyperglycaemia, Nrf-2/HO-1 Signalling Downregulation and Chondrocyte Dysfunction
  15. 15
    “…Osteoarthritis (OA) is the most common rheumatic disease, characterized by progressive articular cartilage degradation. …”
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    Optical Biomarkers for the Diagnosis of Osteoarthritis through Raman Spectroscopy: Radiological and Biochemical Validation Using Ex Vivo Human Cartilage Samples
  16. 16
    “…Osteoarthritis (OA) is a chronic disease that affects articular cartilage, causing its degeneration. …”
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    Histone Extraction from Human Articular Cartilage for the Study of Epigenetic Regulation in Osteoarthritis
  17. 17
    “…Osteoarthritis (OA) is the most common age-related rheumatic disease. …”
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    A pharmacoproteomic study confirms the synergistic effect of chondroitin sulfate and glucosamine
  18. 18
    “…During recent years, the significant influence of mitochondria on osteoarthritis (OA), the most common joint disease, has been consistently demonstrated. …”
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    Mitochondrial Genetics and Epigenetics in Osteoarthritis
  19. 19
    “…The association between obesity and osteoarthritis (OA) in joints not subjected to mechanical overload, together with the relationship between OA and metabolic syndrome, suggests that there are systemic factors related to metabolic disorders that are involved in the metabolic phenotype of OA. …”
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    Oleate Prevents Palmitate-Induced Mitochondrial Dysfunction in Chondrocytes
  20. 20
    “…Changes in the composition and physical properties of the ECM lead to the development of many diseases, including osteoarthritis (OA). OA is a chronic degenerative rheumatic disease characterized by a progressive loss of synovial joint function as a consequence of the degradation of articular cartilage, also associated with alterations in the synovial membrane and subchondral bone. …”
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    Profile of Matrix-Remodeling Proteinases in Osteoarthritis: Impact of Fibronectin
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