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1por Blum, Kenneth, Oscar-Berman, Marlene, DiNubile, Nicholas, Giordano, John, Braverman, Eric R, Truesdell, Courtney E, Barh, Debmalya, Badgaiyan, RajendraEnlace del recurso
Publicado 2013
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2por Blum, Kenneth, Oscar-Berman, Marlene, Demetrovics, Zsolt, Barh, Debmalya, Gold, Mark S.“…Interestingly, albeit others, in one published study, we were able to describe lifetime RDS behaviors in a recovering addict (17 years sober) blindly by assessing resultant Genetic Addiction Risk Score (GARS™) data only. We hypothesize that genetic testing at an early age may be an effective preventive strategy to reduce or eliminate pathological substance and behavioral seeking activity. …”
Publicado 2014
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3por Blum, Kenneth, Kazmi, Shan, Modestino, Edward J., Downs, Bill William, Bagchi, Debasis, Baron, David, McLaughlin, Thomas, Green, Richard, Jalali, Rehan, Thanos, Panayotis K., Elman, Igor, Badgaiyan, Rajendra D., Bowirrat, Abdalla, Gold, Mark S.“…The formulations are based on the results of the addiction risk severity (GARS) test. Based on both neurogenetic and epigenetic evidence, the test evaluates the presence of reward genes and risk alleles. …”
Publicado 2021
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4por Blum, Kenneth, Green, Richard, Smith, Jessica, Llanos-Gomez, Luis, Baron, David, Badgaiyan, Rajendra DEnlace del recurso
Publicado 2020
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5por Blum, Kenneth, Simpatico, Thomas, Badgaiyan, Rajendra D., Demetrovics, Zsolt, Fratantonio, James, Agan, Gozde, Febo, Marcelo, Gold, Mark S.“…We propose a Reward Deficiency System Solution that promotes early identification and stratification of risk alleles by utilizing GARS(Dx), allowing for customized nutrigenomic targeting of these risk alleles by altering KB220Z ingredients as an algorithmic function of carrying these polymorphic DNA–SNPS, potentially yielding the first ever nutrigenomic solution for addiction and pain.…”
Publicado 2015
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6por Moran, Mark, Blum, Kenneth, Ponce, Jessica Valdez, Lott, Lisa, Gondré–Lewis, Marjorie C., Badgaiyan, Sampada, Brewer, Raymond, Downs, B. William, Fynman, Philip, Weingarten, Alexander, Cadet, Jean Lud, Smith, David E., Baron, David, Thanos, Panayotis K., Modestino, Edward J., Badgaiyan, Rajendra D., Elman, Igor, Gold, Mark S.“…Evaluation of pain clinic patients with the Genetic Addiction Risk Score (GARS) test and the Addiction Severity Index (ASI- Media Version V) revealed that GARS scores equal to or greater than 4 and 7 alleles significantly predicted drug and alcohol severity, respectively. …”
Publicado 2021
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7por Modestino, Edward Justin, Blum, Kenneth, Dennen, Catherine A., Downs, B. William, Bagchi, Debasis, Llanos-Gomez, Luis, Elman, Igor, Baron, David, Thanos, Panayotis K., Badgaiyan, Rajendra D., Braverman, Eric R., Gupta, Ashim, Gold, Mark S., Bowirrat, AbdallaEnlace del recurso
Publicado 2022
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8por Blum, Kenneth, Han, David, Gupta, Ashim, Baron, David, Braverman, Eric R., Dennen, Catherine A., Kazmi, Shan, Llanos-Gomez, Luis, Badgaiyan, Rajendra D., Elman, Igor, Thanos, Panayotis K., Downs, Bill W., Bagchi, Debasis, Gondre-Lewis, Marjorie C., Gold, Mark S., Bowirrat, Abdalla“…While most of the research related to GARS is derived from our laboratory, we are encouraging more independent research to confirm our findings.…”
Publicado 2022
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9por Gupta, Ashim, Bowirrat, Abdalla, Gomez, Luis Llanos, Baron, David, Elman, Igor, Giordano, John, Jalali, Rehan, Badgaiyan, Rajendra D., Modestino, Edward J., Gold, Mark S., Braverman, Eric R., Bajaj, Anish, Blum, Kenneth“…The GARS test results identify high-risk for both drug and alcohol, and H-Wave can be initiated to treat pain instead of opioids. …”
Publicado 2022
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10por Blum, Kenneth, Brodie, Mark S., Pandey, Subhash C., Cadet, Jean Lud, Gupta, Ashim, Elman, Igor, Thanos, Panayotis K., Gondre-Lewis, Marjorie C., Baron, David, Kazmi, Shan, Bowirrat, Abdalla, Febo, Marcelo, Badgaiyan, Rajendra D., Braverman, Eric R., Dennen, Catherine A., Gold, Mark S.“…We present a hypothesis that identification of KCNK13 and RASGRF2 genes’ risk polymorphism, coupled with genetic addiction risk score (GARS)-guided precision pro-dopamine regulation, will mitigate binge alcohol drinking. …”
Publicado 2022
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11por Ceccanti, Mauro, Blum, Kenneth, Bowirrat, Abdalla, Dennen, Catherine A., Braverman, Eric R., Baron, David, Mclaughlin, Thomas, Giordano, John, Gupta, Ashim, Downs, Bernard W., Bagchi, Debasis, Barh, Debmalya, Elman, Igor, Thanos, Panayotis K., Badgaiyan, Rajendra D., Edwards, Drew, Gold, Mark S.“…Therefore, based on this extensive literature and additional research, this team of coauthors suggests that, in the future, in addition to the current nonpharmacological therapies, patients with opioid-induced NAS should undergo genetic assessment (i.e., the genetic addiction risk severity (GARS) test), which can subsequently be used to guide DNA-directed precision amino-acid enkephalinase inhibition (KB220) therapy as a frontline modality instead of potent opioids.…”
Publicado 2022
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12por Thanos, Panayotis K., Hanna, Colin, Mihalkovic, Abrianna, Hoffman, Aaron B., Posner, Alan R., Busch, John, Smith, Caroline, Badgaiyan, Rajendra D., Blum, Kenneth, Baron, David, Mastrandrea, Lucy D., Quattrin, Teresa“…Of the 11 risk alleles identified by GARS, the DRD4 risk allele (rs1800955), was significantly correlated with change in weight and BMI six months post-surgery. …”
Publicado 2023
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13por Dennen, Catherine A., Blum, Kenneth, Bowirrat, Abdalla, Thanos, Panayotis K., Elman, Igor, Ceccanti, Mauro, Badgaiyan, Rajendra D., McLaughlin, Thomas, Gupta, Ashim, Bajaj, Anish, Baron, David, Downs, B. William, Bagchi, Debasis, Gold, Mark S.“…This case series presents the novel genetic addiction risk score (GARS), which shows a high prevalence of polymorphic risk alleles of reward genes in a nuclear family with multiple reward deficiency syndrome (RDS) behavioral issues expressing a hypodopaminergic antecedent. …”
Publicado 2022
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14por Blum, Kenneth, Han, David, Bowirrat, Abdalla, Downs, Bernard William, Bagchi, Debasis, Thanos, Panayotis K., Baron, David, Braverman, Eric R., Dennen, Catherine A., Gupta, Ashim, Elman, Igor, Badgaiyan, Rajendra D., Llanos-Gomez, Luis, Khalsa, Jag, Barh, Debmalya, McLaughlin, Thomas, Gold, Mark S.“…To develop an accurate test to help identify those at risk for at least alcohol use disorder (AUD), a subset of reward deficiency syndrome (RDS), Blum’s group developed the genetic addiction risk severity (GARS) test, consisting of ten genes and eleven associated risk alleles. …”
Publicado 2022
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15por Thanos, Panayotis K., Hanna, Colin, Mihalkovic, Abrianna, Hoffman, Aaron, Posner, Alan, Butsch, John, Blum, Kenneth, Georger, Lesley, Mastrandrea, Lucy D., Quattrin, Teresa“…Thirty (30) patients were assessed for Genetic Addiction Risk Severity (GARS), which analyzes neurogenetic polymorphisms involved in addiction and reward deficiency. …”
Publicado 2023
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16por Blum, Kenneth, Badgaiyan, Rajendra D., Agan, Gozde, Fratantonio, James, Simpatico, Thomas, Febo, Marcelo, Haberstick, Brett C., Smolen, Andrew, Gold, Mark S.“…CONCLUSION: Albeit our bias, this Clinical Pearl discusses the facts and fictions behind molecular genetic testing in RDS and the significance behind the development of the Genetic Addiction Risk Score (GARS(PREDX)™), the first test to accurately predict one’s genetic risk for RDS.…”
Publicado 2015
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17Reward Deficiency Syndrome (RDS): A Cytoarchitectural Common Neurobiological Trait of All Addictionspor Blum, Kenneth, Bowirrat, Abdalla, Braverman, Eric R., Baron, David, Cadet, Jean Lud, Kazmi, Shan, Elman, Igor, Thanos, Panyotis K., Badgaiyan, Rajendra D., Downs, William B., Bagchi, Debasis, Llanos-Gomez, Luis, Gold, Mark S.“…Taking a Genetic Addiction Risk Severity (GARS) test combined with a the KB220Z semi-customized nutrigenomic supplement effectively restores dopamine homeostasis (WC 199).…”
Publicado 2021
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18por Blum, Kenneth, Thanos, Panayotis K, Hanna, Colin, Gold, Mark S, Baron, David, Elman, Igor“…Several from Blum et al showed the clinical relevance of the Genetic Addiction Risk Severity (GARS) test in identifying risk for reward deficiency behaviors in cohorts from polysubstance abuse and pain clinics, post-surgical bariatrics, and DWI offenders facing prison time. …”
Publicado 2023
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19por Dennen A., Catherine, Blum, Kenneth, Braverman R., Eric, Bowirrat, Abdalla, Gold, Marks, Elman, Igor, Thanos K., Panayotis, Baron, David, Gupta, Ashim, Edwards, Drew, Badgaiyan D., Rajendra“…Screening for preaddiction could be achieved through genetic testing (i.e., the genetic addiction risk severity (GARS) test) and/or through other neuropsychiatric testing (i.e., Memory (CNSVS), Attention (TOVA), Neuropsychiatric (MCMI-III), Neurological Imaging (qEEG/P300/EP)). …”
Publicado 2023
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20por Blum, Kenneth, Bowirrat, Abdalla, Braverman, Eric R, Dennen, Catherine, Zeine, Foojan, Jafari, Nicole, Sunder, Keerthy, Thanos, Panayotis K., Baron, David, Barh, Debmayla, Gupta, Ashim, Bagchi, Debasis, Gold, Mark S, Badgaiyan, Rajendra D.“…The development of the Genetic Addiction Risk Severity (GARS) test, Blum’s group believes that this type of testing should be the “standard of care” following additional studies. …”
Publicado 2023
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