“…Here we construct an individual-based mathematical model of this process, which is parametrised using existing empirical findings from mice. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…However, heterogeneity of drug penetration of the tumor microenvironment both on the microscopic level within solid tumors as well as on the macroscopic level across metastases may also contribute to acquired drug resistance. Here we use mathematical models to investigate the effect of drug heterogeneity on the probability of escape from treatment and the time to resistance. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…On the other hand, it increases the probability to accumulate more resistant genotypes. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Here we develop a tractable mathematical model of disease transmission and the TTIQ intervention to quantify how the probability of detecting and isolating a case following symptom onset, the fraction of contacts that are identified and quarantined, and the delays inherent to these processes impact epidemic growth. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso