“…Interestingly, K(i)(app)­ with CRO (0.07 ± 0.01 µM) was comparable to that with MEM (0.09 ± 0.01 µM). [Figure: see text] [Figure: see text] [Figure: see text] CONCLUSION: CRO was effective in lowering MICs with MEM, IPM, and CLA for our Mtb isolates. …”
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“…A Wilcoxon signed-rank analysis confirmed that the change in MIC values for all β-lactam combinations compared to β-lactams alone reached statistical significance (p-value < 0.001, Figure 2). [Figure: see text] [Figure: see text] [Figure: see text] CONCLUSION: In this study, we demonstrate that the susceptibility of MAC to MEM is restored with the addition of CPT and CDR. …”
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“…In silico models suggest that INDEL mutations have different effects depending on the structural domain affected [Figure: see text] [Figure: see text] CONCLUSION: INDEL mutations in the three hotspots of KPC-2 can impair CZA activity, but not affect IMI/REL susceptibility. …”
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“…Therefore, we hypothesized that substitutions at position 224 in NDM-1 could also have a similar effect and potentially confer FEP/TAN resistance. [Figure: see text] [Figure: see text] METHODS: NDM-1 clones containing all 19 amino acid variants at position 224 were synthesized (Genscript, NJ) and used to transform E. coli DH10B. …”
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“…Effective treatment was associated with 19% lower odds of mortality (OR 0.81, 95% CI 0.66–1.01), while DTR and XDR/PDR nearly doubled mortality (OR 1.75, 95% CI 1.23–2.47 and OR 2.06, 95% CI 1.25–3.34, respectively). [Figure: see text] [Figure: see text] [Figure: see text] CONCLUSION: We observed higher odds of mortality in patients with PA-BSI and COVID-19 coinfection, supporting the hypothesis that COVID-19 directly impacts PA-BSI outcomes. …”
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“…BACKGROUND: Nacubactam, formerly RG6080 and OP0595 (Figure 1A), is a bridged diazabicyclooctane (DBO) that inactivates class A and class C β-lactamases. …”
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“…We simulated therapy guided by RMDs and compared with the observed empiric BLs using a DOOR-MAT score (Figure 1). RESULTS: A total of 36,531 BSI cases were identified. …”
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“…R2-loop substitutions were observed in FDC-exposed resistant strains, whereas Ω-loop mutations were observed in resistant strains that had not been exposed to FDC. Figure 1. [Figure: see text] Alignment of amino acid sequences in the ADC Ω- and R2- loop regions among studied isolates. …”
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“…BLs were grouped into five tiers of increasing spectrum, both with and without a requirement for anaerobic activity (Figure 1). Tiers of BLs across the treatment periods were summarized and compared with the lowest-spectrum tier with an active agent. …”
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“…Desirability of outcome ranking (DOOR) outcomes were determined as shown. Table. [Figure: see text] DOOR Outcomes RESULTS: Median age of 143 patients was 54 years (IQR 40-65 years), and 77/143 (54%) were women. …”
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“…New oxopyrazole agents targeting penicillin-binding proteins (PBPs) based on a non-β-lactam core and incorporating a siderophore moiety (Figure 1) which facilitates transport to the periplasm are being developed that show promise against Gram-negative organisms including multidrug-resistant strains of E. coli, K. pneumoniae and P. aeruginosa. …”
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“…The addition of ETX2514 lowered the MIC(50) from 8 to 1 mg/L (Figure 1B). ETX-2514 effectively inhibited purified OXA-58 (k(2)/K = 2.5 ± 0.3 × 10(5) M(−1) s(−1) and K(i apP =) 0.39 ± 0.01 µM) and ADC-7 (k(2)/K =1.0 ± 0.1 × 10(6) M(−1) s(−1) and K(i app) = 0.11 ± 0.04 µM). …”
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“…The distribution of scores was similar within mortality outcomes across organisms, with the highest scores observed in Kp patients who died (Figure 1). The ROC areas under the curve were 0.71 for CNS-Ecc and 0.75 for CNS-Kp (Figure 2). …”
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“…RESULTS: Among 18,813 courses of CAZ or ATM, 3,432 ATM and 2,662 CAZ courses met our criteria (Figure 1). While the overall rate of any DILI was higher in ATM than CAZ (5.8% vs. 3.2%, P < 0.01), the rate of moderate/severe DILI was similarly low for both agents (1.6% in ATM vs. 1.3% in CAZ, P = 0.3). …”
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“…RESULTS: At the end of 10 passages, collateral sensitivity in A. baumannii was observed to tigecycline and fosfomycin in 5 and 6 replicates respectively, out of 12 total. 4 out of 12 E. coli replicates displayed collateral sensitivity to minocycline (Figure 1). In the third E. coli replicate, Sanger sequencing revealed a novel S286R mutation in bla(ADC-7) appearing in passage seven which preceded a several log fold increase in the MIC of cefepime (Figures 2 and 3). …”
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“…In this analysis, the antimicrobial activity of LR-R3 against type CRAB hypervirulent strain AB5075 was evaluated. Figure 1 [Figure: see text] A) Transwell migration assay. …”
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“…WT-MetaDynamics (WT MDS) predicts the opening of a hidden pocket by repositioning residue 221 (Figure 1).). Figure 1: (Left) We carried out enhanced sampling metadynamics simulations to generate free-energy landscapes as a function of the dihedral angles of residue 221. …”
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“…Fifteen Pa isolates, (9 sequence type (ST) 2100 and 1 ST463) with varying AST patterns were found (figure). MBST with DDA revealed active combinations for isolates resistant to individual antibiotics (table). …”
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“…VNRX-7145 is currently in development with the oral cephalosporin, ceftibuten (CTB) (Figure 1). [Image: see text] Figure 1. Structures of VNRX-7145, VNRX-5236, and ceftibuten. …”
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“…New oxopyrazole agents targeting penicillin-binding proteins (PBPs) based on a non-β-lactam core and incorporating a siderophore moiety (figure) which facilitates transport to the periplasm are being developed which show promise against Gram-negative organisms including Acinetobacter spp. …”
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