Mostrando 1 - 20 Resultados de 57 Para Buscar '"art"', tiempo de consulta: 0.46s Limitar resultados
  1. 1
    “…Antiretroviral therapy (ART) is not curative due to the persistence of a reservoir of HIV-infected cells, particularly in tissues such as lymph nodes, with the potential to cause viral rebound after treatment cessation. …”
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    Limited impact of fingolimod treatment during the initial weeks of ART in SIV-infected rhesus macaques
  2. 2
    “…There was a marked divergence of HIV DNA values between the untreated and treated groups that occurred within the first 2 weeks of ART and increased with time. ART reduced total HIV DNA levels by 20-fold after 2 weeks and 316-fold after 3 years. …”
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    HIV DNA Set Point is Rapidly Established in Acute HIV Infection and Dramatically Reduced by Early ART()()
  3. 3
    “…HIV persists in a small pool of latently infected cells despite antiretroviral therapy (ART). Identifying cellular markers expressed at the surface of these cells may lead to novel therapeutic strategies to reduce the size of the HIV reservoir. …”
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    CD4(+) T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ART
  4. 4
    “…HIV persists in latently infected CD4(+) T cells during antiretroviral therapy (ART). Immune checkpoint molecules, including PD-1, are preferentially expressed at the surface of persistently infected cells. …”
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    PD-1 blockade potentiates HIV latency reversal ex vivo in CD4(+) T cells from ART-suppressed individuals
  5. 5
    “…Here, we analyze the TCR repertoire of single HIV-infected cells harboring translation-competent proviruses in longitudinal samples from eight individuals on antiretroviral therapy (ART). When compared to uninfected cells, the TCR repertoire of reservoir cells is heavily biased: expanded clonotypes are present in all individuals, account for the majority of reservoir cells and are often maintained over time on ART. …”
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    Single-cell TCR sequencing reveals phenotypically diverse clonally expanded cells harboring inducible HIV proviruses during ART
  6. 6
    “…Before initiation of antiretroviral therapy (ART), HIV-specific CD8(+) T cells are dysfunctional and short lived. …”
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    An active HIV reservoir during ART is associated with maintenance of HIV-specific CD8(+) T cell magnitude and short-lived differentiation status
  7. 7
    “…BACKGROUND: It is unknown if extremely early initiation of antiretroviral therapy (ART) may lead to long-term ART-free HIV remission or cure. …”
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    HIV-1 persistence following extremely early initiation of antiretroviral therapy (ART) during acute HIV-1 infection: An observational study
  8. 8
    “…INTRODUCTION: People living with HIV (PLWH) on antiretroviral therapy (ART) do not progress to AIDS. However, they still suffer from an increased risk of inflammation-associated complications. …”
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    Effect of metformin on the size of the HIV reservoir in non-diabetic ART-treated individuals: single-arm non-randomised Lilac pilot study protocol
  9. 9
    “…Clinical outcomes are inferior for individuals with HIV having suboptimal CD4 T-cell recovery during antiretroviral therapy (ART). We investigated if the levels of infection and the response to homeostatic cytokines of CD4 T-cell subsets contributed to divergent CD4 T-cell recovery and HIV reservoir during ART by studying virologically-suppressed immunologic responders (IR, achieving a CD4 cell count >500 cells/μL on or before two years after ART initiation), and virologically-suppressed suboptimal responders (ISR, did not achieve a CD4 cell count >500 cells/μL in the first two years after ART initiation). …”
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    Increased homeostatic cytokines and stability of HIV-infected memory CD4 T-cells identify individuals with suboptimal CD4 T-cell recovery on-ART
  10. 10
    “…INTRODUCTION: Despite the success of antiretroviral therapy (ART) in transforming HIV disease into a chronic infection, people living with HIV (PLWH) remain at risk for various non-AIDS inflammatory comorbidities. …”
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    Camu Camu effects on microbial translocation and systemic immune activation in ART-treated people living with HIV: protocol of the single-arm non-randomised Camu Camu prebiotic pilot study (CIHR/CTN PT032)
  11. 11
    “…METHODS: Fifteen participants who initiated ART at AHI were randomized to vorinostat/hydroxychloroquine/maraviroc (VHM) plus ART (n ​= ​10) or ART alone (n ​= ​5). …”
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    A randomized trial of vorinostat with treatment interruption after initiating antiretroviral therapy during acute HIV-1 infection
  12. 12
    “…BACKGROUND: Early antiretroviral therapy (ART) initiation (ie, within 3 months of infection) limits establishment of the HIV reservoir. …”
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    Long-term effects of early antiretroviral initiation on HIV reservoir markers: a longitudinal analysis of the MERLIN clinical study
  13. 13
    “…Although HIV-specific CD8(+) T cells become dysfunctional without treatment, antiretroviral therapy (ART) partially restores their function. However, the extent of this recovery under long-term ART is less understood. …”
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    Long-term antiretroviral therapy initiated in acute HIV infection prevents residual dysfunction of HIV-specific CD8(+) T cells
  14. 14
    “…In conclusion, intestinal IL-17 producing cell function is severely impaired by SIV infection, not fully normalized despite effective ART, and strongly associates with inflammation as well as SIV persistence off and on ART. …”
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    Loss of Function of Intestinal IL-17 and IL-22 Producing Cells Contributes to Inflammation and Viral Persistence in SIV-Infected Rhesus Macaques
  15. 15
    “…In contrast, the concentration of sLAG-3 was similar in uninfected individuals and PWH on ART, but was significantly elevated in PWH off ART. …”
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    Soluble immune checkpoints as correlates for HIV persistence and T cell function in people with HIV on antiretroviral therapy
  16. 16
    “…Combination antiretroviral therapy (cART) has led to a major reduction in HIV-related mortality and morbidity. …”
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    Finding a cure for HIV: will it ever be achievable?
  17. 17
    “…Here, we undertook a thorough analysis of pulmonary versus blood DN T cells of people living with HIV (PLWH) under ART. Bronchoalveolar lavage (BAL) fluid and matched peripheral blood were collected from 35 PLWH on ART and 16 uninfected volunteers without respiratory symptoms. …”
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    HIV Infection and Persistence in Pulmonary Mucosal Double Negative T Cells In Vivo
  18. 18
    “…ART in Fiebig I–IV resulted in normalisation of CD4 cell count within the first year, supporting the benefit of early ART. …”
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    Virological and immunological characteristics of HIV-infected individuals at the earliest stage of infection
  19. 19
    “…Most recent evidence supports the contribution of long-lived Th17 cells to HIV persistence during antiretroviral therapy (ART). However, the identity of long-lived Th17 cells remains unknown. …”
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    New insights into the heterogeneity of Th17 subsets contributing to HIV-1 persistence during antiretroviral therapy
  20. 20
    por Kulpa, Deanna A, Chomont, Nicolas
    Publicado 2015
    “…In infected individuals taking ART, HIV persists in a small number of cells that can survive for the lifetime of the infected person. …”
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    HIV persistence in the setting of antiretroviral therapy: when, where and how does HIV hide?
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