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1por Pino, Maria, Pagliuzza, Amélie, Pampena, M. Betina, Deleage, Claire, Viox, Elise G., Nguyen, Kevin, Shim, Inbo, Zhang, Adam, Harper, Justin L., Samer, Sadia, King, Colin T., Cervasi, Barbara, Gill, Kiran P., Ehnert, Stephanie, Jean, Sherrie M., Freeman, Michael L., Lifson, Jeffrey D., Kulpa, Deanna, Betts, Michael R., Chomont, Nicolas, Lederman, Michael M., Paiardini, Mirko“…Antiretroviral therapy (ART) is not curative due to the persistence of a reservoir of HIV-infected cells, particularly in tissues such as lymph nodes, with the potential to cause viral rebound after treatment cessation. …”
Publicado 2022
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2por Ananworanich, Jintanat, Chomont, Nicolas, Eller, Leigh Ann, Kroon, Eugene, Tovanabutra, Sodsai, Bose, Meera, Nau, Martin, Fletcher, James L.K., Tipsuk, Somporn, Vandergeeten, Claire, O'Connell, Robert J., Pinyakorn, Suteeraporn, Michael, Nelson, Phanuphak, Nittaya, Robb, Merlin L.“…There was a marked divergence of HIV DNA values between the untreated and treated groups that occurred within the first 2 weeks of ART and increased with time. ART reduced total HIV DNA levels by 20-fold after 2 weeks and 316-fold after 3 years. …”
Publicado 2016
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3por Fromentin, Rémi, Bakeman, Wendy, Lawani, Mariam B., Khoury, Gabriela, Hartogensis, Wendy, DaFonseca, Sandrina, Killian, Marisela, Epling, Lorrie, Hoh, Rebecca, Sinclair, Elizabeth, Hecht, Frederick M., Bacchetti, Peter, Deeks, Steven G., Lewin, Sharon R., Sékaly, Rafick-Pierre, Chomont, Nicolas“…HIV persists in a small pool of latently infected cells despite antiretroviral therapy (ART). Identifying cellular markers expressed at the surface of these cells may lead to novel therapeutic strategies to reduce the size of the HIV reservoir. …”
Publicado 2016
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4por Fromentin, Rémi, DaFonseca, Sandrina, Costiniuk, Cecilia T., El-Far, Mohamed, Procopio, Francesco Andrea, Hecht, Frederick M., Hoh, Rebecca, Deeks, Steven G., Hazuda, Daria J., Lewin, Sharon R., Routy, Jean-Pierre, Sékaly, Rafick-Pierre, Chomont, Nicolas“…HIV persists in latently infected CD4(+) T cells during antiretroviral therapy (ART). Immune checkpoint molecules, including PD-1, are preferentially expressed at the surface of persistently infected cells. …”
Publicado 2019
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5por Gantner, Pierre, Pagliuzza, Amélie, Pardons, Marion, Ramgopal, Moti, Routy, Jean-Pierre, Fromentin, Rémi, Chomont, Nicolas“…Here, we analyze the TCR repertoire of single HIV-infected cells harboring translation-competent proviruses in longitudinal samples from eight individuals on antiretroviral therapy (ART). When compared to uninfected cells, the TCR repertoire of reservoir cells is heavily biased: expanded clonotypes are present in all individuals, account for the majority of reservoir cells and are often maintained over time on ART. …”
Publicado 2020
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6por Takata, Hiroshi, Mitchell, Julie L., Pacheco, Julian, Pagliuzza, Amélie, Pinyakorn, Suteeraporn, Buranapraditkun, Supranee, Sacdalan, Carlo, Leyre, Louise, Nathanson, Sam, Kakazu, Juyeon C., Intasan, Jintana, Prueksakaew, Peeriya, Chomchey, Nitiya, Phanuphak, Nittaya, de Souza, Mark, Haddad, Elias K., Rolland, Morgane, Tovanabutra, Sodsai, Vasan, Sandhya, Hsu, Denise C., Chomont, Nicolas, Trautmann, Lydie“…Before initiation of antiretroviral therapy (ART), HIV-specific CD8(+) T cells are dysfunctional and short lived. …”
Publicado 2023
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7por Henrich, Timothy J., Hatano, Hiroyu, Bacon, Oliver, Hogan, Louise E., Rutishauser, Rachel, Hill, Alison, Kearney, Mary F., Anderson, Elizabeth M., Buchbinder, Susan P., Cohen, Stephanie E., Abdel-Mohsen, Mohamed, Pohlmeyer, Christopher W., Fromentin, Remi, Hoh, Rebecca, Liu, Albert Y., McCune, Joseph M., Spindler, Jonathan, Metcalf-Pate, Kelly, Hobbs, Kristen S., Thanh, Cassandra, Gibson, Erica A., Kuritzkes, Daniel R., Siliciano, Robert F., Price, Richard W., Richman, Douglas D., Chomont, Nicolas, Siliciano, Janet D., Mellors, John W., Yukl, Steven A., Blankson, Joel N., Liegler, Teri, Deeks, Steven G.“…BACKGROUND: It is unknown if extremely early initiation of antiretroviral therapy (ART) may lead to long-term ART-free HIV remission or cure. …”
Publicado 2017
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8por Routy, Jean-Pierre, Isnard, Stéphane, Mehraj, Vikram, Ostrowski, Mario, Chomont, Nicolas, Ancuta, Petronela, Ponte, Rosalie, Planas, Delphine, Dupuy, Franck P, Angel, Jonathan B“…INTRODUCTION: People living with HIV (PLWH) on antiretroviral therapy (ART) do not progress to AIDS. However, they still suffer from an increased risk of inflammation-associated complications. …”
Publicado 2019
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9por Pino, Maria, Pereira Ribeiro, Susan, Pagliuzza, Amélie, Ghneim, Khader, Khan, Anum, Ryan, Emily, Harper, Justin L., King, Colin T., Welbourn, Sarah, Micci, Luca, Aldrete, Sol, Delman, Keith A., Stuart, Theron, Lowe, Michael, Brenchley, Jason M., Derdeyn, Cynthia A., Easley, Kirk, Sekaly, Rafick P., Chomont, Nicolas, Paiardini, Mirko, Marconi, Vincent C.“…Clinical outcomes are inferior for individuals with HIV having suboptimal CD4 T-cell recovery during antiretroviral therapy (ART). We investigated if the levels of infection and the response to homeostatic cytokines of CD4 T-cell subsets contributed to divergent CD4 T-cell recovery and HIV reservoir during ART by studying virologically-suppressed immunologic responders (IR, achieving a CD4 cell count >500 cells/μL on or before two years after ART initiation), and virologically-suppressed suboptimal responders (ISR, did not achieve a CD4 cell count >500 cells/μL in the first two years after ART initiation). …”
Publicado 2021
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10por Isnard, Stéphane, Fombuena, Brandon, Ouyang, Jing, Royston, Léna, Lin, John, Bu, Simeng, Sheehan, Nancy, Lakatos, Peter L, Bessissow, Talat, Chomont, Nicolas, Klein, Marina, Lebouché, Bertrand, Costiniuk, Cecilia T, Routy, Bertrand, Marette, André, Routy, Jean-Pierre“…INTRODUCTION: Despite the success of antiretroviral therapy (ART) in transforming HIV disease into a chronic infection, people living with HIV (PLWH) remain at risk for various non-AIDS inflammatory comorbidities. …”
Publicado 2022
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11por Kroon, Eugène D.M.B., Ananworanich, Jintanat, Pagliuzza, Amélie, Rhodes, Ajantha, Phanuphak, Nittaya, Trautmann, Lydie, Mitchell, Julie L., Chintanaphol, Michelle, Intasan, Jintana, Pinyakorn, Suteeraporn, Benjapornpong, Khuntalee, Chang, J. Judy, Colby, Donn J., Chomchey, Nitiya, Fletcher, James L.K., Eubanks, Keith, Yang, Hua, Kapson, John, Dantanarayana, Ashanti, Tennakoon, Surekha, Gorelick, Robert J., Maldarelli, Frank, Robb, Merlin L., Kim, Jerome H., Spudich, Serena, Chomont, Nicolas, Phanuphak, Praphan, Lewin, Sharon R., de Souza, Mark S.“…METHODS: Fifteen participants who initiated ART at AHI were randomized to vorinostat/hydroxychloroquine/maraviroc (VHM) plus ART (n = 10) or ART alone (n = 5). …”
Publicado 2020
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12por Massanella, Marta, Ignacio, Rachel A Bender, Lama, Javier R, Pagliuzza, Amélie, Dasgupta, Sayan, Alfaro, Ricardo, Rios, Jessica, Ganoza, Carmela, Pinto-Santini, Delia, Gilada, Trupti, Duerr, Ann, Chomont, Nicolas“…BACKGROUND: Early antiretroviral therapy (ART) initiation (ie, within 3 months of infection) limits establishment of the HIV reservoir. …”
Publicado 2021
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13por Takata, Hiroshi, Kakazu, Juyeon C., Mitchell, Julie L., Kroon, Eugene, Colby, Donn J., Sacdalan, Carlo, Bai, Hongjun, Ehrenberg, Philip K., Geretz, Aviva, Buranapraditkun, Supranee, Pinyakorn, Suteeraporn, Intasan, Jintana, Tipsuk, Somporn, Suttichom, Duanghathai, Prueksakaew, Peeriya, Chalermchai, Thep, Chomchey, Nitiya, Phanuphak, Nittaya, de Souza, Mark, Michael, Nelson L., Robb, Merlin L., Haddad, Elias K., Crowell, Trevor A, Vasan, Sandhya, Valcour, Victor G., Douek, Daniel C., Thomas, Rasmi, Rolland, Morgane, Chomont, Nicolas, Ananworanich, Jintanat, Trautmann, Lydie“…Although HIV-specific CD8(+) T cells become dysfunctional without treatment, antiretroviral therapy (ART) partially restores their function. However, the extent of this recovery under long-term ART is less understood. …”
Publicado 2022
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14por Ryan, Emily S., Micci, Luca, Fromentin, Rémi, Paganini, Sara, McGary, Colleen S., Easley, Kirk, Chomont, Nicolas, Paiardini, Mirko“…In conclusion, intestinal IL-17 producing cell function is severely impaired by SIV infection, not fully normalized despite effective ART, and strongly associates with inflammation as well as SIV persistence off and on ART. …”
Publicado 2016
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15por Chiu, Chris Y., Schou, Maya D., McMahon, James H., Deeks, Steven G., Fromentin, Rémi, Chomont, Nicolas, Wykes, Michelle N., Rasmussen, Thomas A., Lewin, Sharon R.“…In contrast, the concentration of sLAG-3 was similar in uninfected individuals and PWH on ART, but was significantly elevated in PWH off ART. …”
Publicado 2023
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16por Lewin, Sharon R, Evans, Vanessa A, Elliott, Julian H, Spire, Bruno, Chomont, Nicolas“…Combination antiretroviral therapy (cART) has led to a major reduction in HIV-related mortality and morbidity. …”
Publicado 2011
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17por Meziane, Oussama, Salahuddin, Syim, Pham, Tram N. Q., Farnos, Omar, Pagliuzza, Amélie, Olivenstein, Ron, Thomson, Elaine, Alexandrova, Yulia, Orlova, Marianna, Schurr, Erwin, Ancuta, Petronela, Haddad, Élie, Chomont, Nicolas, Cohen, Eric A., Jenabian, Mohammad-Ali, Costiniuk, Cecilia T.“…Here, we undertook a thorough analysis of pulmonary versus blood DN T cells of people living with HIV (PLWH) under ART. Bronchoalveolar lavage (BAL) fluid and matched peripheral blood were collected from 35 PLWH on ART and 16 uninfected volunteers without respiratory symptoms. …”
Publicado 2020
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18por Ananworanich, Jintanat, Sacdalan, Carlo P., Pinyakorn, Suteeraporn, Chomont, Nicolas, Souza, Mark, Luekasemsuk, Tassanee, Schuetz, Alexandra, Krebs, Shelly J, Dewar, Robin, Jagodzinski, Linda, Ubolyam, Sasiwimol, Trichavaroj, Rapee, Tovanabutra, Sodsai, Spudich, Serena, Valcour, Victor, Sereti, Irini, Michael, Nelson, Robb, Merlin, Phanuphak, Praphan, Kim, Jerome H., Phanuphak, Nittaya“…ART in Fiebig I–IV resulted in normalisation of CD4 cell count within the first year, supporting the benefit of early ART. …”
Publicado 2016
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19por Wacleche, Vanessa Sue, Goulet, Jean-Philippe, Gosselin, Annie, Monteiro, Patricia, Soudeyns, Hugo, Fromentin, Rémi, Jenabian, Mohammad-Ali, Vartanian, Shant, Deeks, Steven G., Chomont, Nicolas, Routy, Jean-Pierre, Ancuta, Petronela“…Most recent evidence supports the contribution of long-lived Th17 cells to HIV persistence during antiretroviral therapy (ART). However, the identity of long-lived Th17 cells remains unknown. …”
Publicado 2016
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20“…In infected individuals taking ART, HIV persists in a small number of cells that can survive for the lifetime of the infected person. …”
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