Mostrando 1 - 11 Resultados de 11 Para Buscar '"Snatch"', tiempo de consulta: 0.15s Limitar resultados
  1. 1
    “…Cap-snatching was first discovered in influenza virus. …”
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    Structural insights into reptarenavirus cap-snatching machinery
  2. 2
    “…However the putative Thogotovirus cap-snatching domains in PA and PB2 have non-conservative substitutions of key active site residues. …”
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    Comparative Structural and Functional Analysis of Orthomyxovirus Polymerase Cap-Snatching Domains
  3. 3
    “…We present the structure of the cap-snatching EN of Hantaan virus, a bunyavirus belonging to hantavirus genus. …”
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    Comparative Structural and Functional Analysis of Bunyavirus and Arenavirus Cap-Snatching Endonucleases
  4. 4
    “…Hantaviruses presumably initiate their mRNA synthesis by using cap structures derived from host cell mRNAs, a mechanism called cap-snatching. A signature for a cap-snatching endonuclease is present in the N terminus of hantavirus L proteins. …”
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    Atomic Structure and Biochemical Characterization of an RNA Endonuclease in the N Terminus of Andes Virus L Protein
  5. 5
    “…It was recently shown that the cap-snatching endonuclease of influenza virus resides in a discrete N-terminal domain of the PA polymerase subunit. …”
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    Bunyaviridae RNA Polymerases (L-Protein) Have an N-Terminal, Influenza-Like Endonuclease Domain, Essential for Viral Cap-Dependent Transcription
  6. 6
    “…In particular, the unique cap-snatching mechanism of viral transcription can be inhibited by targeting either the PB2 cap-binding or PA endonuclease domains. …”
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    Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza pH1N1 (2009) Polymerase
  7. 7
    “…A short, capped primer, ′cap-snatched′ from a nascent host polymerase II transcript, is directed towards the polymerase active site to initiate RNA synthesis. …”
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    Structural snapshots of actively transcribing influenza polymerase
  8. 8
    “…Influenza virus uses a unique cap-snatching mechanism characterized by hijacking and cleavage of host capped pre-mRNAs, resulting in short capped RNAs, which are used as primers for viral mRNA synthesis. …”
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    Characterization of PA-N terminal domain of Influenza A polymerase reveals sequence specific RNA cleavage
  9. 9
    “…In recent structures of promoter-bound polymerase, the cap-binding and endonuclease domains are configured for cap snatching, which generates capped transcription primers. …”
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    Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of PB2 Domains
  10. 10
    “…Influenza polymerase uses short capped primers snatched from nascent Pol II transcripts to initiate transcription of viral mRNAs. …”
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    Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors
  11. 11
    “…Initiation of viral mRNA synthesis requires a direct association of FluPol with the host RNA polymerase II (RNAP II), in particular the repetitive C-terminal domain (CTD) of the major RNAP II subunit, to enable “cap-snatching” whereby 5’-capped oligomers derived from nascent RNAP II transcripts are pirated to prime viral transcription. …”
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    Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD
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