por
Sobotta, Svantje,
Raue, Andreas,
Huang, Xiaoyun,
Vanlier, Joep,
Jünger, Anja,
Bohl, Sebastian,
Albrecht, Ute,
Hahnel, Maximilian J.,
Wolf, Stephanie,
Mueller, Nikola S.,
D'Alessandro, Lorenza A.,
Mueller-Bohl, Stephanie,
Boehm, Martin E.,
Lucarelli, Philippe,
Bonefas, Sandra,
Damm, Georg,
Seehofer, Daniel,
Lehmann, Wolf D.,
Rose-John, Stefan,
van der Hoeven, Frank,
Gretz, Norbert,
Theis, Fabian J.,
Ehlting, Christian,
Bode, Johannes G.,
Timmer, Jens,
Schilling, Marcel,
Klingmüller, Ursula
Publicado 2017
“…While different inhibitors of IL-6-induced JAK1-STAT3-signaling have been developed, understanding their precise impact on signaling
dynamics requires a
systems biology approach. Here we present a
mathematical model of IL-6-induced JAK1-STAT3 signaling that quantitatively links physiological IL-6 concentrations to the
dynamics of IL-6-induced signal transduction and expression of target genes in hepatocytes. …”
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