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1por Kostyak, John C., Mauri, Benjamin, Dangelmaier, Carol, Vari, Hymavathi Reddy, Patel, Akruti, Wright, Monica, Reddy, Haritha, Tsygankov, Alexander Y., Kunapuli, Satya P.“…Immune cells express receptors bearing an immune tyrosine activation motif (ITAM) containing two YXXL motifs or hemITAMs containing only one YXXL motif. …”
Publicado 2022
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2por Dangelmaier, Carol, Vari, Hymavathi Reddy, Wright, Monica, Kostyak, John C., Kunapuli, Satya P.“…OBJECTIVES: One proposed hypothesis for signaling cascade is that Syk bridges two receptors through phosphorylated hemITAM motifs. We demonstrated that the phosphorylated hemITAM stimulates PI3 kinase/Btk pathways to activate Syk. …”
Publicado 2022
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3“…GP1b was shown to signal via the FcRγ-ITAM (Fc Receptor γ-Immunoreceptor tyrosine-based activation motif) pathway, activating spleen tyrosine kinase (Syk) and other tyrosine kinases. …”
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4por Kostyak, John C., Mauri, Benjamin R., Dangelmaier, Carol, Patel, Akruti, Zhou, Yuhang, Eble, Johannes A., Tsygankov, Alexander Y., McKenzie, Steven E., Kunapuli, Satya P.“…Central to platelet activation are the signals transmitted through surface receptors such as glycoprotein VI, the protease-activated receptors, and C-type lectin-like receptor 2 (CLEC-2). CLEC-2 is a HemITAM (hem-immunoreceptor tyrosine activation motif)-bearing receptor that binds podoplanin and signals through spleen tyrosine kinase (Syk). …”
Publicado 2018
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