-
1por Bacchus-Souffan, Charline, Fitch, Mark, Symons, Jori, Abdel-Mohsen, Mohamed, Reeves, Daniel B., Hoh, Rebecca, Stone, Mars, Hiatt, Joseph, Kim, Peggy, Chopra, Abha, Ahn, Haelee, York, Vanessa A., Cameron, Daniel L., Hecht, Frederick M., Martin, Jeffrey N., Yukl, Steven A., Mallal, Simon, Cameron, Paul U., Deeks, Steven G., Schiffer, Joshua T., Lewin, Sharon R., Hellerstein, Marc K., McCune, Joseph M., Hunt, Peter W.“…The precise role of CD4 T cell turnover in maintaining HIV persistence during antiretroviral therapy (ART) has not yet been well characterized. In resting CD4 T cell subpopulations from 24 HIV-infected ART-suppressed and 6 HIV-uninfected individuals, we directly measured cellular turnover by heavy water labeling, HIV reservoir size by integrated HIV-DNA (intDNA) and cell-associated HIV-RNA (caRNA), and HIV reservoir clonality by proviral integration site sequencing. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
2por Fromentin, Rémi, Bakeman, Wendy, Lawani, Mariam B., Khoury, Gabriela, Hartogensis, Wendy, DaFonseca, Sandrina, Killian, Marisela, Epling, Lorrie, Hoh, Rebecca, Sinclair, Elizabeth, Hecht, Frederick M., Bacchetti, Peter, Deeks, Steven G., Lewin, Sharon R., Sékaly, Rafick-Pierre, Chomont, Nicolas“…HIV persists in a small pool of latently infected cells despite antiretroviral therapy (ART). Identifying cellular markers expressed at the surface of these cells may lead to novel therapeutic strategies to reduce the size of the HIV reservoir. …”
Publicado 2016
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
3por Ogongo, Paul, Tran, Anthony, Marzan, Florence, Gingrich, David, Krone, Melissa, Aweeka, Francesca, Arlehamn, Cecilia S Lindestam, Martin, Jeffrey N., Deeks, Steven G., Hunt, Peter W., Ernst, Joel D.“…We performed high-definition characterization of circulating Mtb-specific Th17 cells by spectral flow cytometry in people with latent TB and treated HIV (HIV-ART). We also measured kynurenine pathway activity in plasma by LC/MS and tested the hypothesis that tryptophan catabolism influences Th17 cell differentiation in this context. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4por Booiman, Thijs, Wit, Ferdinand W., Girigorie, Arginell F., Maurer, Irma, De Francesco, Davide, Sabin, Caroline A., Harskamp, Agnes M., Prins, Maria, Franceschi, Claudio, Deeks, Steven G., Winston, Alan, Reiss, Peter, Kootstra, Neeltje A.“…HIV-1-positive individuals on successful antiretroviral therapy (ART) are reported to have higher rates of age-associated non-communicable comorbidities (AANCCs). …”
Publicado 2017
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5por Fromentin, Rémi, DaFonseca, Sandrina, Costiniuk, Cecilia T., El-Far, Mohamed, Procopio, Francesco Andrea, Hecht, Frederick M., Hoh, Rebecca, Deeks, Steven G., Hazuda, Daria J., Lewin, Sharon R., Routy, Jean-Pierre, Sékaly, Rafick-Pierre, Chomont, Nicolas“…HIV persists in latently infected CD4(+) T cells during antiretroviral therapy (ART). Immune checkpoint molecules, including PD-1, are preferentially expressed at the surface of persistently infected cells. …”
Publicado 2019
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
6por Henrich, Timothy J., Hatano, Hiroyu, Bacon, Oliver, Hogan, Louise E., Rutishauser, Rachel, Hill, Alison, Kearney, Mary F., Anderson, Elizabeth M., Buchbinder, Susan P., Cohen, Stephanie E., Abdel-Mohsen, Mohamed, Pohlmeyer, Christopher W., Fromentin, Remi, Hoh, Rebecca, Liu, Albert Y., McCune, Joseph M., Spindler, Jonathan, Metcalf-Pate, Kelly, Hobbs, Kristen S., Thanh, Cassandra, Gibson, Erica A., Kuritzkes, Daniel R., Siliciano, Robert F., Price, Richard W., Richman, Douglas D., Chomont, Nicolas, Siliciano, Janet D., Mellors, John W., Yukl, Steven A., Blankson, Joel N., Liegler, Teri, Deeks, Steven G.“…BACKGROUND: It is unknown if extremely early initiation of antiretroviral therapy (ART) may lead to long-term ART-free HIV remission or cure. …”
Publicado 2017
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
7por Swainson, Louise A., Sharma, Ashish Arunkumar, Ghneim, Khader, Ribeiro, Susan Pereira, Wilkinson, Peter, Dunham, Richard M., Albright, Rebecca G., Wong, Samson, Estes, Jacob D., Piatak, Michael, Deeks, Steven G., Hunt, Peter W., Sekaly, Rafick-Pierre, McCune, Joseph M.“…Overall, these data demonstrated that IFN-α blockade during ART-treated SIV infection was safe and associated with the induction of immune/erythroid pathways that reduced viral persistence during ART while mitigating the weight loss and anemia that typically ensue after ART interruption.…”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
8por Vásquez, Joshua J., Aguilar-Rodriguez, Brandon L., Rodriguez, Leonardo, Hogan, Louise E., Somsouk, Ma, McCune, Joseph M., Deeks, Steven G., Laszik, Zoltan G., Hunt, Peter W., Henrich, Timothy J.“…RESULTS: HIV-RNA+ cells were more abundant in tissues from viremic individuals than in those receiving suppressive anti-retroviral therapy (ART). However, staining by both methods indicated that a higher proportion of HIV-RNA+ cells co-expressed CD32-RNA in ART-suppressed individuals than in those with viremia. …”
Publicado 2019
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
9por Serrano-Villar, Sergio, Wu, Kunling, Hunt, Peter W., Lok, Judith J., Ron, Raquel, Sainz, Talía, Moreno, Santiago, Deeks, Steven G., Bosch, Ronald J.“…METHODS: We selected treatment-naive individuals initiating ART from ACTG studies 384, 388, A5095, A5142, A5202, and A5257 who had achieved viral suppression at year 2. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
10por Lee, Guinevere Q., Swenson, Luke C., Poon, Art F. Y., Martin, Jeffrey N., Hatano, Hiroyu, Deeks, Steven G., Harrigan, P. RichardEnlace del recurso
Publicado 2012
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
11por Emu, Brinda, Moretto, Walter J., Hoh, Rebecca, Krone, Melissa, Martin, Jeffrey N., Nixon, Douglas F., Deeks, Steven G., McCune, Joseph M.“…This study aimed to characterize quantitative and qualitative aspects of various T cell subpopulations that do not improve despite effective ART. CD4∶CD8 ratio was evaluated in HIV-infected subjects with viral loads >10,000 copies/µl (“non-controllers”, n = 42), those with undetectable viral loads on ART (“ART-suppressed”, n = 53), and HIV-uninfected subjects (n = 22). …”
Publicado 2014
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
12por Chiu, Chris Y., Schou, Maya D., McMahon, James H., Deeks, Steven G., Fromentin, Rémi, Chomont, Nicolas, Wykes, Michelle N., Rasmussen, Thomas A., Lewin, Sharon R.“…In contrast, the concentration of sLAG-3 was similar in uninfected individuals and PWH on ART, but was significantly elevated in PWH off ART. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
13por McMyn, Natalie F., Varriale, Joseph, Fray, Emily J., Zitzmann, Carolin, MacLeod, Hannah, Lai, Jun, Singhal, Anushka, Moskovljevic, Milica, Garcia, Mauro A., Lopez, Brianna M., Hariharan, Vivek, Rhodehouse, Kyle, Lynn, Kenneth, Tebas, Pablo, Mounzer, Karam, Montaner, Luis J., Benko, Erika, Kovacs, Colin, Hoh, Rebecca, Simonetti, Francesco R., Laird, Gregory M., Deeks, Steven G., Ribeiro, Ruy M., Perelson, Alan S., Siliciano, Robert F., Siliciano, Janet M.“…HIV-1 persists in a latent reservoir in resting CD4(+) T cells despite antiretroviral therapy (ART). The reservoir decays slowly over the first 7 years of ART (t(1/2) = 44 months). …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
14por Phillips, Andrew N., Cambiano, Valentina, Revill, Paul, Nakagawa, Fumiyo, Lundgren, Jens D., Bansi-Matharu, Loveleen, Mabugu, Travor, Sculpher, Mark, Garnett, Geoff, Staprans, Silvija, Becker, Stephen, Murungu, Joseph, Lewin, Sharon R., Deeks, Steven G., Hallett, Timothy B.“…It is unknown what properties would be required to make an intervention in low income countries that can eradicate or control human immunodeficiency virus (HIV) without antiretroviral therapy (ART) cost-effective. Methods. We used a model of HIV and ART to investigate the effect of introducing an ART-free viral suppression intervention in 2022 using Zimbabwe as an example country. …”
Publicado 2016
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
15por Hatano, Hiroyu, Yukl, Steven A., Ferre, April L., Graf, Erin H., Somsouk, Ma, Sinclair, Elizabeth, Abdel-Mohsen, Mohamed, Liegler, Teri, Harvill, Kara, Hoh, Rebecca, Palmer, Sarah, Bacchetti, Peter, Hunt, Peter W., Martin, Jeffrey N., McCune, Joseph M., Tracy, Russell P., Busch, Michael P., O'Doherty, Una, Shacklett, Barbara L., Wong, Joseph K., Deeks, Steven G.“…Sixteen asymptomatic controllers were prospectively treated with ART for 24 weeks. Controllers had a statistically significant decrease in ultrasensitive plasma and rectal HIV RNA levels with ART. …”
Publicado 2013
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
16por Seu, Lillian, Ortiz, Gabriel M., Epling, Lorrie, Sinclair, Elizabeth, Swainson, Louise A., Bajpai, Urmila D., Huang, Yong, Deeks, Steven G., Hunt, Peter W., Martin, Jeffrey N., McCune, Joseph M.“…HIV-mediated immune dysfunction may influence CD4(+) T cell recovery during suppressive antiretroviral therapy (ART). We analyzed cellular biomarkers of immunological inflammation, maturation, and senescence in HIV-infected subjects on early suppressive ART. …”
Publicado 2013
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
17por Zerbato, Jennifer M., Khoury, Georges, Zhao, Wei, Gartner, Matthew J., Pascoe, Rachel D., Rhodes, Ajantha, Dantanarayana, Ashanti, Gooey, Megan, Anderson, Jenny, Bacchetti, Peter, Deeks, Steven G., McMahon, James, Roche, Michael, Rasmussen, Thomas A., Purcell, Damian FJ, Lewin, Sharon R.“…BACKGROUND: One strategy being pursued to clear latently infected cells that persist in people living with HIV (PLWH) on antiretroviral therapy (ART) is to activate latent HIV infection with a latency reversing agent (LRA). …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
18“…PURPOSE OF REVIEW: The present review will highlight some of the recent findings regarding the capacity of HIV-1 to replicate during antiretroviral therapy (ART). RECENT FINDINGS: Although ART is highly effective at inhibiting HIV replication, it is not curative. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
19por Bruner, Katherine M., Murray, Alexandra J., Pollack, Ross A., Soliman, Mary G., Laskey, Sarah B., Capoferri, Adam A., Lai, Jun, Strain, Matthew C., Lada, Steven M., Hoh, Rebecca, Ho, Ya-Chi, Richman, Douglas D., Deeks, Steven G., Siliciano, Janet D., Siliciano, Robert F.“…Although antiretroviral therapy (ART) suppresses viral replication to clinically undetectable levels, HIV-1 persists in CD4(+) T cells in a latent form not targeted by the immune system or ART(1–5). …”
Publicado 2016
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
20por Serrano-Villar, Sergio, Sainz, Talia, Lee, Sulggi A., Hunt, Peter W., Sinclair, Elizabeth, Shacklett, Barbara L., Ferre, April L., Hayes, Timothy L., Somsouk, Ma, Hsue, Priscilla Y., Van Natta, Mark L., Meinert, Curtis L., Lederman, Michael M., Hatano, Hiroyu, Jain, Vivek, Huang, Yong, Hecht, Frederick M., Martin, Jeffrey N., McCune, Joseph M., Moreno, Santiago, Deeks, Steven G.“…A subset of HIV-infected adults receiving effective antiretroviral therapy (ART) fails to normalize this ratio, even after they achieve normal CD4+ T cell counts. …”
Publicado 2014
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto