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  1. 1
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    Propionibacterium acnes in Human Health and Disease
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    “…BACKGROUND: Sarcoidosis is caused by Th1-type immune responses to unknown agents, and is linked to the infectious agent Propionibacterium acnes. Many strains of P. acnes isolated from sarcoid lesions cause intracellular infection and autophagy may contribute to the pathogenesis of sarcoidosis. …”
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    Autophagy Induced by Intracellular Infection of Propionibacterium acnes
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    “…Immunohistochemistry revealed Propionibacterium acnes in the noncaseating granulomas. The present findings suggest that Propionibacterium acnes is a cause of sarcoidosis, even when the disease is induced by TNF-α inhibitors.…”
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    Development of Propionibacterium acnes-associated Sarcoidosis During Etanercept Therapy
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    “…Propionibacterium acnes is a potential etiologic agent of sarcoidosis and a dysregulated immune response to the commensal bacterium is suspected to cause granuloma formation. …”
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    Propionibacterium acnes-Derived Circulating Immune Complexes in Sarcoidosis Patients
  5. 5
    por Eishi, Yoshinobu
    Publicado 2023
    “…C. acnes is the sole microorganism ever isolated from sarcoid lesions. …”
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    Potential Association of Cutibacterium acnes with Sarcoidosis as an Endogenous Hypersensitivity Infection
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    por Eishi, Yoshinobu
    Publicado 2013
    “…Sarcoidosis is a systemic granulomatous disease of unknown etiology. Propionibacterium acnes is the only microorganism that has been isolated from sarcoid lesions. …”
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    Etiologic Aspect of Sarcoidosis as an Allergic Endogenous Infection Caused by Propionibacterium acnes
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    “…To investigate whether P. acnes is an etiological agent for sarcoid uveitis, we analyzed the frequency of P. acnes detected within the biopsied retinas from patients with ocular sarcoidosis by immunohistochemistry with a P. acnes-specific monoclonal antibody (PAB antibody). …”
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    Immunohistochemical Detection of Propionibacterium acnes in the Retinal Granulomas in Patients with Ocular Sarcoidosis
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    “…Here, we present for the first time a case with Propionibacterium acnes-associated sarcoidosis complicated by acute bird-related HP. …”
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    Propionibacterium acnes-associated sarcoidosis complicated by acute bird-related hypersensitivity pneumonitis
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    “…This seem to be the first report of Propionibacterium acnes-associated sarcoidosis possibly initially triggered by interferon-alpha therapy. …”
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    Propionibacterium acnes-associated Sarcoidosis Possibly Initially Triggered by Interferon-alpha Therapy
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    “…We report the complete genome sequence of P. acnes, which was isolated from a Japanese patient with sarcoidosis.…”
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    Complete Genome Sequence of a Propionibacterium acnes Isolate from a Sarcoidosis Patient
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    “…BACKGROUND: Recent reports on Propionibacterium acnes (P. acnes) suggest that this bacterium is prevalent in the prostate, is associated with acute and chronic prostatic inflammation, and might have a role in prostate carcinogenesis. …”
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    Intracellular Propionibacterium acnes Infection in Glandular Epithelium and Stromal Macrophages of the Prostate with or without Cancer
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    “…Here we describe EOS/BS with a novel mutation in the NOD2 gene, as well as detection of Propionibacterium acnes (P. acnes) in the granulomatous inflammation. …”
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    A novel mutation in early‐onset sarcoidosis/Blau syndrome: an association with Propionibacterium acnes
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    “…Mycobacterial and propionibacterial organisms are the most commonly implicated potential etiologic agents. Propionibacterium acnes is the only microorganism, however, found in sarcoid lesions by bacterial culture. …”
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    Localization of Propionibacterium acnes in granulomas supports a possible etiologic link between sarcoidosis and the bacterium
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    “…BACKGROUND: Propionibacterium acnes is thought to be a causative agent of sarcoidosis. …”
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    Propionibacterium acnes-derived insoluble immune complexes in sinus macrophages of lymph nodes affected by sarcoidosis
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    “…Several studies demonstrated that Propionibacterium acnes may be involved in sarcoidosis pathogenesis. …”
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    Presence of Propionibacterium acnes in granulomas associates with a chronic disease course in Dutch sarcoidosis patients
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    “…In particular, Propionibacterium acnes and Mycobacterium tuberculosis have been considered causative microorganisms. …”
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    Successful treatment in a case of Propionibacterium acnes-associated sarcoidosis with clarithromycin administration: a case report
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    “…An anaerobic culture of the biopsied right mastoid showed the growth of P. acnes, and histopathological examination using P. acnes-specific monoclonal antibody (PAB antibody) revealed the infiltration of inflammatory cells with P. acnes. …”
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    Propionibacterium acnes-associated chronic hypertrophic pachymeningitis followed by refractory otitis media: a case report
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    “…We aimed to detect Propionibacterium acnes, a commonly implicated etiologic agent of sarcoidosis, in myocardial tissues obtained from CS patients. …”
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    Immunohistochemical identification of Propionibacterium acnes in granuloma and inflammatory cells of myocardial tissues obtained from cardiac sarcoidosis patients
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    “…Small arteries were damaged by granulomas. Both M. avium and P. acnes were detected in the lesion. Furthermore, more P. acnes genomes were detected in the granulomas than in the non-lesion lung. …”
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    A Solitary Necrotizing Sarcoid Granulomatosis-like Pulmonary Lesion Possibly Associated with Propionibacterium acnes and Mycobacterium avium
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    “…Propionibacterium acnes is one of the most commonly implicated etiologic agents of sarcoidosis. …”
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    Genetic profiles of Propionibacterium acnes and identification of a unique transposon with novel insertion sequences in sarcoid and non-sarcoid isolates
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