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1por Cohen, Ouri, Yu, Victoria Y., Tringale, Kathryn R., Young, Robert J., Perlman, Or, Farrar, Christian T., Otazo, Ricardo“…PURPOSE: To develop a clinical CEST MR fingerprinting (CEST‐MRF) method for brain tumor quantification using EPI acquisition and deep learning reconstruction. …”
Publicado 2022
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2“…The system (termed AutoCEST) is composed of a CEST saturation block, a spin dynamics module, and a deep reconstruction network, all differentiable and jointly connected. …”
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3por Fillion, Adam J., Bricco, Alexander R., Lee, Harvey D., Korenchan, David, Farrar, Christian T., Gilad, Assaf A.“…Chemical Exchange Saturation Transfer (CEST) magnetic resonance imaging (MRI) has been identified as a novel alternative to classical diagnostic imaging. …”
Publicado 2023
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4por Perlman, Or, Ito, Hirotaka, Gilad, Assaf A., McMahon, Michael T., Chiocca, E. Antonio, Nakashima, Hiroshi, Farrar, Christian T.“…However, the highly repetitive nature of the LRP reporter gene sequence leads to DNA recombination events and the expression of a range of truncated LRP protein fragments, thereby greatly limiting the CEST sensitivity. Here we report the use of a redesigned LRP reporter (rdLRP), aimed to provide excellent stability and CEST sensitivity. …”
Publicado 2020
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5por Perlman, Or, Ito, Hirotaka, Herz, Kai, Shono, Naoyuki, Nakashima, Hiroshi, Zaiss, Moritz, Chiocca, E. Antonio, Cohen, Ouri, Rosen, Matthew S., Farrar, Christian T.“…A deep neural network, previously trained with simulated MR-fingerprints, then generates, using CEST-MRF image data, quantitative maps of intratumoral pH, and protein and lipid concentrations. …”
Publicado 2022
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6por Scalzitti, Nicolas, Miralavy, Iliya, Korenchan, David E., Farrar, Christian T., Gilad, Assaf A., Banzhaf, Wolfgang“…CONCLUSIONS: By combining the power of genetic programming with the flexibility of regular expressions, new potential peptide targets were identified to improve the sensitivity of detection by CEST. This approach provides a promising research direction for the efficient identification of peptides with therapeutic or diagnostic potential.…”
Publicado 2023
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7“…The applicability of this simulated data for in-silico, in-vitro, and in-vivo imaging applications is then demonstrated for chemical exchange saturation transfer (CEST) and semisolid macromolecule magnetization transfer (MT) analysis and quantification. …”
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