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1por Seeley, Janet, Bond, Virginia, Yang, Blia, Floyd, Sian, MacLeod, David, Viljoen, Lario, Phiri, Mwelwa, Simuyaba, Melvin, Hoddinott, Graeme, Shanaube, Kwame, Bwalya, Chiti, de Villiers, Laing, Jennings, Karen, Mwanza, Margaret, Schaap, Ab, Dunbar, Rory, Sabapathy, Kalpana, Ayles, Helen, Bock, Peter, Hayes, Richard, Fidler, Sarah“…To achieve UNAIDS 90:90:90 targets at population-level, knowledge of HIV status must be followed by timely linkage to care, initiation and maintenance of antiretroviral therapy (ART) for all people living with HIV (PLHIV). Interpreting quantitative patterns using qualitative data, we investigate time taken to link to care and initiate ART amongst individuals aware of their HIV-status in high HIV-prevalence urban communities in the HPTN 071 (PopART) study, a community-randomised trial of a combination HIV prevention package, including universal testing and treatment, in 21 communities in Zambia and South Africa. …”
Publicado 2018
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2por Pickles, Michael, Cori, Anne, Probert, William J. M., Sauter, Rafael, Hinch, Robert, Fidler, Sarah, Ayles, Helen, Bock, Peter, Donnell, Deborah, Wilson, Ethan, Piwowar-Manning, Estelle, Floyd, Sian, Hayes, Richard J., Fraser, Christophe“…We show how the model calibrates within a Bayesian inference framework to detailed age- and sex-stratified data from multiple sources on HIV prevalence, awareness of HIV status, ART status, and viral suppression for an HPTN 071 (PopART) study community in Zambia, and present future projections of HIV prevalence and incidence for this community in the absence of trial intervention.…”
Publicado 2021
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3por Sabapathy, Kalpana, Mubekapi‐Musadaidzwa, Constance, Mulubwa, Chama, Schaap, Ab, Hoddinott, Graeme, Stangl, Anne, Floyd, Sian, Ayles, Helen, Fidler, Sarah, Hayes, Richard“…This nested study examined factors associated with timely linkage‐to‐care and ART initiation (TLA) (i.e. within six‐months of referral) in the context of UTT within the intervention communities of the HPTN 071 (PopART) trial. …”
Publicado 2017
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4por Limbada, Mohammed, Bwalya, Chiti, Macleod, David, Shibwela, Osborn, Floyd, Sian, Nzara, Diana, Situmbeko, Vasty, Hayes, Richard, Fidler, Sarah, Ayles, Helen“…Community delivery of Antiretroviral therapy (ART) is a novel innovation to increase sustainable ART coverage for People living with HIV (PLHIV) in resource limited settings. …”
Publicado 2021
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5por Skalland, Timothy, Ayles, Helen, Bock, Peter, Bwalya, Justin, Shanaube, Kwame, Kasese, Nkatya, Dupré, Michelle, Kosloff, Barry, Floyd, Sian, Wilson, Ethan, Moore, Ayana, Eshleman, Susan, Fidler, Sarah, Hayes, Richard, Donnell, Deborah“…CLINICAL TRIAL NUMBER: ClinicalTrials.gov number, NCT01900977, HPTN 071 [PopArt]…”
Publicado 2023
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6por Macleod, David, Shanaube, Kwame, Skalland, Timothy, Limbada, Mohammed, Mandla, Nomtha, Bwalya, Justin, Schaap, Ab, Yang, Blia, Donnell, Deborah, Piwowar-Manning, Estelle, Eshleman, Susan H, Hoddinott, Graeme, Bond, Virginia, Moore, Ayana, Griffith, Sam, Bock, Peter, Ayles, Helen, Fidler, Sarah, Hayes, Richard, Floyd, Sian“…BACKGROUND: In 2014, UNAIDS set the target that 90% of individuals on antiretroviral therapy (ART) be virally suppressed. Here, we use data from the HPTN 071 (PopART) trial to report whether the introduction of universal testing and treatment has affected viral suppression or treatment adherence among individuals who self-reported they were taking ART, and identify risk factors for these outcomes. …”
Publicado 2022
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7por Grant-McAuley, Wendy, Klock, Ethan, Laeyendecker, Oliver, Piwowar-Manning, Estelle, Wilson, Ethan, Clarke, William, Breaud, Autumn, Moore, Ayana, Ayles, Helen, Kosloff, Barry, Shanaube, Kwame, Bock, Peter, Mandla, Nomtha, van Deventer, Anneen, Fidler, Sarah, Donnell, Deborah, Hayes, Richard, Eshleman, Susan H.“…Seroconverters on antiretroviral treatment (ART) were identified using a qualitative multi-drug assay. …”
Publicado 2021
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8por Grant‐McAuley, Wendy, Piwowar‐Manning, Estelle, Clarke, William, Breaud, Autumn, Zewdie, Kidist Belay, Moore, Ayana, Ayles, Helen Mary, Kosloff, Barry, Shanaube, Kwame, Bock, Peter, Meehan, Sue‐Ann, Maarman, Gerald, Fidler, Sarah, Hayes, Richard, Donnell, Deborah, Eshleman, Susan H.“…INTRODUCTION: HIV controllers have low viral loads (VL) without antiretroviral treatment (ART). We evaluated viraemic control in a community‐randomized trial conducted in Zambia and South Africa that evaluated the impact of a combination prevention intervention on HIV incidence (HPTN 071 [PopART]; 2013–2018). …”
Publicado 2023
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9por Hamlyn, Elizabeth, Ewings, Fiona M., Porter, Kholoud, Cooper, David A., Tambussi, Giuseppe, Schechter, Mauro, Pedersen, Court, Okulicz, Jason F., McClure, Myra, Babiker, Abdel, Weber, Jonathan, Fidler, Sarah“…OBJECTIVES: The magnitude of HIV viral rebound following ART cessation has consequences for clinical outcome and onward transmission. …”
Publicado 2012
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10por Inshaw, Jamie, Leen, Clifford, Fisher, Martin, Gilson, Richard, Hawkins, David, Collins, Simon, Fox, Julie, McLean, Ken, Fidler, Sarah, Phillips, Andrew, Lattimore, Sam, Babiker, Abdel, Porter, Kholoud“…Individuals experienced a somewhat greater decrease in CD4 count following HCV infection lasting 13 months, relative to individuals with HIV alone, (estimate = -3.33, 95% CI [-7.29, 0.63] cells/mm(3) per month, p = 0.099). Of 1502 initiating cART, 106 (7.1%) were HCV co-infected, with no evidence of HCV duration at cART being associated with immunological response (p = 0.45). …”
Publicado 2015
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11por Fidler, Sarah, Olson, Ashley D., Bucher, Heiner C., Fox, Julie, Thornhill, John, Morrison, Charles, Muga, Roberto, Phillips, Andrew, Frater, John, Porter, Kholoud“…BACKGROUND: Few individuals commencing antiretroviral therapy (ART) in primary HIV infection (PHI) maintain undetectable viremia after treatment cessation. …”
Publicado 2017
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12por Shanaube, Kwame, Schaap, Ab, Floyd, Sian, Phiri, Mwelwa, Griffith, Sam, Chaila, Joseph, Bock, Peter, Hayes, Richard, Fidler, Sarah, Ayles, Helen“…OBJECTIVE: To determine the uptake of home-based HIV counselling and testing (HCT) in four HPTN 071 (PopART) trial communities (implementing a ‘full’ combination HIV prevention package that includes universal HIV testing and treatment) in Zambia. …”
Publicado 2017
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13por Fogel, Jessica M., Wilson, Ethan A., Piwowar‐Manning, Estelle, Breaud, Autumn, Clarke, William, Petropoulos, Christos, Moore, Ayana, Fraser, Christophe, Kosloff, Barry, Shanaube, Kwame, van Zyl, Gert, Scheepers, Michelle, Floyd, Sian, Bock, Peter, Ayles, Helen, Fidler, Sarah, Hayes, Richard, Donnell, Deborah, Eshleman, Susan H.“…These participants were classified as failing ART; 88 (93.6%) of the non‐seroconverters failing ART had resistance. …”
Publicado 2022
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14por Limbada, Mohammed, Macleod, David, Situmbeko, Vasty, Muhau, Ellen, Shibwela, Osborn, Chiti, Bwalya, Floyd, Sian, Schaap, Albertus J, Hayes, Richard, Fidler, Sarah, Ayles, Helen“…BACKGROUND: Non-facility-based antiretroviral therapy (ART) delivery for people with stable HIV might increase sustainable ART coverage in low-income and middle-income countries. …”
Publicado 2021
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15por Fidler, Sarah, Olson, Ashley, Fox, Julie, Phillips, Andrew, Morrison, Charles, Thornhill, John, Bucher, Heiner, Muga, Roberto, Porter, Kholoud“…There is some evidence that cART during primary HIV infection (PHI) limits the reservoir size, optimizing the chance of maintaining viral control off cART. …”
Publicado 2014
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16por Fogel, Jessica M, Zewdie, Kidist, Clarke, William A, Piwowar-Manning, Estelle, Breaud, Autumn, Moore, Ayana, Kosloff, Barry, Shanaube, Kwame, van Zyl, Gert, Scheepers, Michelle, Floyd, Sian, Bock, Peter, Ayles, Helen, Fidler, Sarah, Hayes, Richard, Donnell, Deborah, Eshleman, Susan H“…BACKGROUND: Antiretroviral therapy (ART) reduces human immunodeficiency virus (HIV) transmission risk. …”
Publicado 2022
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17por Bell-Mandla, Nomtha, Wilson, Ethan, Sharma, Deeksha, Sloot, Rosa, Bwalya, Justin, Schaap, Ab, Donnell, Deborah, Piwowar-Manning, Estelle, Floyd, Sian, Makola, Nozizwe, Nkonki, Lungiswa, Simwinga, Musonda, Moore, Ayana, Hayes, Richard, Fidler, Sarah, Ayles, Helen, Bock, Peter“…In this study, we have used an individual-level cohort study design to evaluate the association between sex and other baseline characteristics and participant retention in the HPTN 071 (PopART) trial in Zambia and South Africa. METHODS: HPTN 071 (PopART) was a community randomized trial (CRT) conducted from 2013 to 2018, in 21 communities. …”
Publicado 2023
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18por Shanaube, Kwame, Schaap, Ab, Chaila, Mwate Joseph, Floyd, Sian, Mackworth-Young, Constance, Hoddinott, Graeme, Hayes, Richard, Fidler, Sarah, Ayles, Helen“…OBJECTIVE: To determine the uptake of home-based HIV counselling and testing (HCT) in four communities of the HPTN 071 (PopART) trial in Zambia among adolescents aged 15–19 years and explore factors associated with HCT uptake. …”
Publicado 2017
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19por Eshleman, Susan H, Piwowar‐Manning, Estelle, Wilson, Ethan A, Lennon, Denni, Fogel, Jessica M, Agyei, Yaw, Sullivan, Philip A, Weng, Lei, Moore, Ayana, Laeyendecker, Oliver, Kosloff, Barry, Bwalya, Justin, Maarman, Gerald, van Deventer, Anneen, Floyd, Sian, Bock, Peter, Ayles, Helen, Fidler, Sarah, Hayes, Richard, Donnell, Deborah“…INTRODUCTION: The HPTN 071 (PopART) trial evaluated the impact of an HIV combination prevention package that included “universal testing and treatment” on HIV incidence in 21 communities in Zambia and South Africa during 2013‐2018. …”
Publicado 2020
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20por Martin, Genevieve E, Pace, Matthew, Shearer, Freya M, Zilber, Eva, Hurst, Jacob, Meyerowitz, Jodi, Thornhill, John P, Lwanga, Julianne, Brown, Helen, Robinson, Nicola, Hopkins, Emily, Olejniczak, Natalia, Nwokolo, Nneka, Fox, Julie, Fidler, Sarah, Willberg, Christian B, Frater, John“…Initiation of antiretroviral therapy (ART) in early compared with chronic human immunodeficiency virus (HIV) infection is associated with a smaller HIV reservoir. …”
Publicado 2020
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