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1por Gallagher, Kelley A., Schumacher, Maria A., Bush, Matthew J., Bibb, Maureen J., Chandra, Govind, Holmes, Neil A., Zeng, Wenjie, Henderson, Max, Zhang, Hengshan, Findlay, Kim C., Brennan, Richard G., Buttner, Mark J.“…Here we demonstrate that c-di-GMP also intervenes later in development to control differentiation of the reproductive hyphae into spores by arming a novel anti-σ (RsiG) to bind and sequester a sporulation-specific σ factor (σ(WhiG)). We present the structure of the RsiG-(c-di-GMP)(2)-σ(WhiG) complex, revealing an unusual, partially intercalated c-di-GMP dimer bound at the RsiG-σ(WhiG) interface. …”
Publicado 2020
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2por Bush, Matthew J., Bibb, Maureen J., Chandra, Govind, Findlay, Kim C., Buttner, Mark J.“…Several other genes encoding proteins with important roles in development were also identified as WhiA targets, including the sporulation-specific sigma factor σ(WhiG) and the diguanylate cyclase CdgB. Cell division is tightly coordinated with the orderly arrest of apical growth in the sporogenic cell, and filP, encoding a key component of the polarisome that directs apical growth, is a direct target for WhiA-mediated repression during sporulation.…”
Publicado 2013
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