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1“…Using a novel experimental design, we exposed wild‐derived Drosophila melanogaster to three different selection regimes: one where generations alternated between starvation and benign conditions, and starvation was always preceded by early exposure to cold; another where starvation and benign conditions alternated in the same way, but cold shock sometimes preceded starvation and sometimes benign conditions; and a third where conditions were always benign. …”
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2por Flatt, Thomas“…Due to its simple and rapid life cycle, cosmopolitan distribution, ease of maintenance in the laboratory, well-understood evolutionary genetics, and its versatile genetic toolbox, the “vinegar fly” Drosophila melanogaster is one of the most powerful, experimentally tractable model systems for studying “life-history evolution.” …”
Publicado 2020
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3por Wallace, Megan A, Coffman, Kelsey A, Gilbert, Clément, Ravindran, Sanjana, Albery, Gregory F, Abbott, Jessica, Argyridou, Eliza, Bellosta, Paola, Betancourt, Andrea J, Colinet, Hervé, Eric, Katarina, Glaser-Schmitt, Amanda, Grath, Sonja, Jelic, Mihailo, Kankare, Maaria, Kozeretska, Iryna, Loeschcke, Volker, Montchamp-Moreau, Catherine, Ometto, Lino, Onder, Banu Sebnem, Orengo, Dorcas J, Parsch, John, Pascual, Marta, Patenkovic, Aleksandra, Puerma, Eva, Ritchie, Michael G, Rota-Stabelli, Omar, Schou, Mads Fristrup, Serga, Svitlana V, Stamenkovic-Radak, Marina, Tanaskovic, Marija, Veselinovic, Marija Savic, Vieira, Jorge, Vieira, Cristina P, Kapun, Martin, Flatt, Thomas, González, Josefa, Staubach, Fabian, Obbard, Darren J“…Drosophila melanogaster is an important model for antiviral immunity in arthropods, but very few DNA viruses have been described from the family Drosophilidae. …”
Publicado 2021
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4por Fabian, Daniel K, Kapun, Martin, Nolte, Viola, Kofler, Robert, Schmidt, Paul S, Schlötterer, Christian, Flatt, Thomas“…Understanding the genetic underpinnings of adaptive change is a fundamental but largely unresolved problem in evolutionary biology. Drosophila melanogaster, an ancestrally tropical insect that has spread to temperate regions and become cosmopolitan, offers a powerful opportunity for identifying the molecular polymorphisms underlying clinal adaptation. …”
Publicado 2012
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5por Kapun, Martin, van Schalkwyk, Hester, McAllister, Bryant, Flatt, Thomas, Schlötterer, Christian“…Here, we have developed a new set of diagnostic marker SNPs for seven cosmopolitan inversions in Drosophila melanogaster that can be used to infer inversion frequencies from Pool-Seq data. …”
Publicado 2014
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6por Kapun, Martin, Barrón, Maite G, Staubach, Fabian, Obbard, Darren J, Wiberg, R Axel W, Vieira, Jorge, Goubert, Clément, Rota-Stabelli, Omar, Kankare, Maaria, Bogaerts-Márquez, María, Haudry, Annabelle, Waidele, Lena, Kozeretska, Iryna, Pasyukova, Elena G, Loeschcke, Volker, Pascual, Marta, Vieira, Cristina P, Serga, Svitlana, Montchamp-Moreau, Catherine, Abbott, Jessica, Gibert, Patricia, Porcelli, Damiano, Posnien, Nico, Sánchez-Gracia, Alejandro, Grath, Sonja, Sucena, Élio, Bergland, Alan O, Guerreiro, Maria Pilar Garcia, Onder, Banu Sebnem, Argyridou, Eliza, Guio, Lain, Schou, Mads Fristrup, Deplancke, Bart, Vieira, Cristina, Ritchie, Michael G, Zwaan, Bas J, Tauber, Eran, Orengo, Dorcas J, Puerma, Eva, Aguadé, Montserrat, Schmidt, Paul, Parsch, John, Betancourt, Andrea J, Flatt, Thomas, González, Josefa“…Here, we address these issues using a collaborative approach, sequencing 48 pooled population samples from 32 locations, and perform the first continent-wide genomic analysis of genetic variation in European Drosophila melanogaster. Our analyses uncover longitudinal population structure, provide evidence for continent-wide selective sweeps, identify candidate genes for local climate adaptation, and document clines in chromosomal inversion and transposable element frequencies. …”
Publicado 2020
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7“…Although natural infections are known from Drosophila melanogaster and D. simulans, and artificial infections have been reported from several Drosophila species and other insects, it remains unclear to date whether DCV infections also occur naturally in other Drosophila species. …”
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8por Orozco-terWengel, Pablo, Kapun, Martin, Nolte, Viola, Kofler, Robert, Flatt, Thomas, Schlötterer, Christian“…Here, we combined laboratory natural selection (experimental evolution) in Drosophila melanogaster with genome-wide next generation sequencing of DNA pools (Pool-Seq) to identify alleles that are favourable in a novel laboratory environment and traced their trajectories during the adaptive process. …”
Publicado 2012
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9por Rodrigues, Marisa A., Merckelbach, Antoine, Durmaz, Esra, Kerdaffrec, Envel, Flatt, Thomas“…Here, we report that transgenic ablation of germ cells in late development or early adulthood in Drosophila melanogaster causes elevated baseline expression and increased induction of Toll and Imd immune genes upon bacterial infection, as compared to fertile flies with an intact germline. …”
Publicado 2021
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10por May, Christina M., van den Heuvel, Joost, Doroszuk, Agnieszka, Hoedjes, Katja M., Flatt, Thomas, Zwaan, Bas J.“…Here, we assess the consequences of adaptation to three different developmental diets in combination with classical selection for early or late reproduction in the fruit fly Drosophila melanogaster. We find that the response to each selection pressure is similar to that observed when they are applied independently, but the overall magnitude of the response depends on the selection regime experienced in the other life stage. …”
Publicado 2019
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11por Machado, Heather E, Bergland, Alan O, Taylor, Ryan, Tilk, Susanne, Behrman, Emily, Dyer, Kelly, Fabian, Daniel K, Flatt, Thomas, González, Josefa, Karasov, Talia L, Kim, Bernard, Kozeretska, Iryna, Lazzaro, Brian P, Merritt, Thomas JS, Pool, John E, O'Brien, Katherine, Rajpurohit, Subhash, Roy, Paula R, Schaeffer, Stephen W, Serga, Svitlana, Schmidt, Paul, Petrov, Dmitri A“…To advance our understanding of adaptation to temporally varying selection pressures, we identified signatures of seasonal adaptation occurring in parallel among Drosophila melanogaster populations. Specifically, we estimated allele frequencies genome-wide from flies sampled early and late in the growing season from 20 widely dispersed populations. …”
Publicado 2021
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12“…‘Evolve and resequence’ (E&R) studies in Drosophila melanogaster have identified many candidate loci underlying the evolution of ageing and life history, but experiments that validate the effects of such candidates remain rare. …”
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13“…Experimental evolution and genome-wide association studies have demonstrated that variation in the PPARγ-homolog Eip75B has associated with longevity and life-history differences in the fruit fly Drosophila melanogaster. Using RNAi knockdown, we first demonstrate that reduced expression of Eip75B in adult flies affects lifespan, egg-laying rate, and egg volume. …”
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14“…Here we examine this fundamental question by genetically manipulating aminergic neurotransmitter signaling in Drosophila melanogaster. We find that both serotonin and dopamine enhance adult ovarian dormancy, while the downregulation of their respective signaling pathways in endocrine cells or tissues (insulin producing cells, fat body, corpus allatum) reduces dormancy. …”
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15por Durmaz, Esra, Rajpurohit, Subhash, Betancourt, Nicolas, Fabian, Daniel K., Kapun, Martin, Schmidt, Paul, Flatt, Thomas“…A fundamental aim of adaptation genomics is to identify polymorphisms that underpin variation in fitness traits. In Drosophila melanogaster, latitudinal life‐history clines exist on multiple continents and make an excellent system for dissecting the genetics of adaptation. …”
Publicado 2019
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16por Kapun, Martin, Mitchell, Esra Durmaz, Kawecki, Tadeusz J, Schmidt, Paul, Flatt, Thomas“…Since the pioneering work of Dobzhansky in the 1930s and 1940s, many chromosomal inversions have been identified, but how they contribute to adaptation remains poorly understood. In Drosophila melanogaster, the widespread inversion polymorphism In(3R)Payne underpins latitudinal clines in fitness traits on multiple continents. …”
Publicado 2023
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17por Fabian, Daniel K., Garschall, Kathrin, Klepsatel, Peter, Santos‐Matos, Gonçalo, Sucena, Élio, Kapun, Martin, Lemaitre, Bruno, Schlötterer, Christian, Arking, Robert, Flatt, Thomas“…Here, we have analyzed the genomes of a set of Drosophila melanogaster lines that have been maintained under direct selection for postponed reproduction and indirect selection for longevity, relative to unselected control lines, for over 35 years. …”
Publicado 2018
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18por Hoedjes, Katja M., van den Heuvel, Joost, Kapun, Martin, Keller, Laurent, Flatt, Thomas, Zwaan, Bas J.“…To address these questions, we analyzed the genomes of experimentally evolved Drosophila melanogaster populations subjected to a factorial combination of two selection regimes: reproductive age (early versus postponed), and diet during the larval stage (“low,” “control,” “high”), resulting in six treatment combinations with four replicate populations each. …”
Publicado 2019
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19por Kapun, Martin, Nunez, Joaquin C B, Bogaerts-Márquez, María, Murga-Moreno, Jesús, Paris, Margot, Outten, Joseph, Coronado-Zamora, Marta, Tern, Courtney, Rota-Stabelli, Omar, Guerreiro, Maria P García, Casillas, Sònia, Orengo, Dorcas J, Puerma, Eva, Kankare, Maaria, Ometto, Lino, Loeschcke, Volker, Onder, Banu S, Abbott, Jessica K, Schaeffer, Stephen W, Rajpurohit, Subhash, Behrman, Emily L, Schou, Mads F, Merritt, Thomas J S, Lazzaro, Brian P, Glaser-Schmitt, Amanda, Argyridou, Eliza, Staubach, Fabian, Wang, Yun, Tauber, Eran, Serga, Svitlana V, Fabian, Daniel K, Dyer, Kelly A, Wheat, Christopher W, Parsch, John, Grath, Sonja, Veselinovic, Marija Savic, Stamenkovic-Radak, Marina, Jelic, Mihailo, Buendía-Ruíz, Antonio J, Gómez-Julián, Maria Josefa, Espinosa-Jimenez, Maria Luisa, Gallardo-Jiménez, Francisco D, Patenkovic, Aleksandra, Eric, Katarina, Tanaskovic, Marija, Ullastres, Anna, Guio, Lain, Merenciano, Miriam, Guirao-Rico, Sara, Horváth, Vivien, Obbard, Darren J, Pasyukova, Elena, Alatortsev, Vladimir E, Vieira, Cristina P, Vieira, Jorge, Torres, Jorge Roberto, Kozeretska, Iryna, Maistrenko, Oleksandr M, Montchamp-Moreau, Catherine, Mukha, Dmitry V, Machado, Heather E, Lamb, Keric, Paulo, Tânia, Yusuf, Leeban, Barbadilla, Antonio, Petrov, Dmitri, Schmidt, Paul, Gonzalez, Josefa, Flatt, Thomas, Bergland, Alan O“…Drosophila melanogaster is a leading model in population genetics and genomics, and a growing number of whole-genome data sets from natural populations of this species have been published over the last years. …”
Publicado 2021
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