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1por Seeley, Janet, Bond, Virginia, Yang, Blia, Floyd, Sian, MacLeod, David, Viljoen, Lario, Phiri, Mwelwa, Simuyaba, Melvin, Hoddinott, Graeme, Shanaube, Kwame, Bwalya, Chiti, de Villiers, Laing, Jennings, Karen, Mwanza, Margaret, Schaap, Ab, Dunbar, Rory, Sabapathy, Kalpana, Ayles, Helen, Bock, Peter, Hayes, Richard, Fidler, Sarah“…To achieve UNAIDS 90:90:90 targets at population-level, knowledge of HIV status must be followed by timely linkage to care, initiation and maintenance of antiretroviral therapy (ART) for all people living with HIV (PLHIV). Interpreting quantitative patterns using qualitative data, we investigate time taken to link to care and initiate ART amongst individuals aware of their HIV-status in high HIV-prevalence urban communities in the HPTN 071 (PopART) study, a community-randomised trial of a combination HIV prevention package, including universal testing and treatment, in 21 communities in Zambia and South Africa. …”
Publicado 2018
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2por Pickles, Michael, Cori, Anne, Probert, William J. M., Sauter, Rafael, Hinch, Robert, Fidler, Sarah, Ayles, Helen, Bock, Peter, Donnell, Deborah, Wilson, Ethan, Piwowar-Manning, Estelle, Floyd, Sian, Hayes, Richard J., Fraser, Christophe“…We show how the model calibrates within a Bayesian inference framework to detailed age- and sex-stratified data from multiple sources on HIV prevalence, awareness of HIV status, ART status, and viral suppression for an HPTN 071 (PopART) study community in Zambia, and present future projections of HIV prevalence and incidence for this community in the absence of trial intervention.…”
Publicado 2021
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3por Sabapathy, Kalpana, Mubekapi‐Musadaidzwa, Constance, Mulubwa, Chama, Schaap, Ab, Hoddinott, Graeme, Stangl, Anne, Floyd, Sian, Ayles, Helen, Fidler, Sarah, Hayes, Richard“…This nested study examined factors associated with timely linkage‐to‐care and ART initiation (TLA) (i.e. within six‐months of referral) in the context of UTT within the intervention communities of the HPTN 071 (PopART) trial. …”
Publicado 2017
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4por Limbada, Mohammed, Bwalya, Chiti, Macleod, David, Shibwela, Osborn, Floyd, Sian, Nzara, Diana, Situmbeko, Vasty, Hayes, Richard, Fidler, Sarah, Ayles, Helen“…Community delivery of Antiretroviral therapy (ART) is a novel innovation to increase sustainable ART coverage for People living with HIV (PLHIV) in resource limited settings. …”
Publicado 2021
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5por Skalland, Timothy, Ayles, Helen, Bock, Peter, Bwalya, Justin, Shanaube, Kwame, Kasese, Nkatya, Dupré, Michelle, Kosloff, Barry, Floyd, Sian, Wilson, Ethan, Moore, Ayana, Eshleman, Susan, Fidler, Sarah, Hayes, Richard, Donnell, Deborah“…CLINICAL TRIAL NUMBER: ClinicalTrials.gov number, NCT01900977, HPTN 071 [PopArt]…”
Publicado 2023
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6por Macleod, David, Shanaube, Kwame, Skalland, Timothy, Limbada, Mohammed, Mandla, Nomtha, Bwalya, Justin, Schaap, Ab, Yang, Blia, Donnell, Deborah, Piwowar-Manning, Estelle, Eshleman, Susan H, Hoddinott, Graeme, Bond, Virginia, Moore, Ayana, Griffith, Sam, Bock, Peter, Ayles, Helen, Fidler, Sarah, Hayes, Richard, Floyd, Sian“…BACKGROUND: In 2014, UNAIDS set the target that 90% of individuals on antiretroviral therapy (ART) be virally suppressed. Here, we use data from the HPTN 071 (PopART) trial to report whether the introduction of universal testing and treatment has affected viral suppression or treatment adherence among individuals who self-reported they were taking ART, and identify risk factors for these outcomes. …”
Publicado 2022
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7por Shanaube, Kwame, Schaap, Ab, Floyd, Sian, Phiri, Mwelwa, Griffith, Sam, Chaila, Joseph, Bock, Peter, Hayes, Richard, Fidler, Sarah, Ayles, Helen“…OBJECTIVE: To determine the uptake of home-based HIV counselling and testing (HCT) in four HPTN 071 (PopART) trial communities (implementing a ‘full’ combination HIV prevention package that includes universal HIV testing and treatment) in Zambia. …”
Publicado 2017
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8por Fogel, Jessica M., Wilson, Ethan A., Piwowar‐Manning, Estelle, Breaud, Autumn, Clarke, William, Petropoulos, Christos, Moore, Ayana, Fraser, Christophe, Kosloff, Barry, Shanaube, Kwame, van Zyl, Gert, Scheepers, Michelle, Floyd, Sian, Bock, Peter, Ayles, Helen, Fidler, Sarah, Hayes, Richard, Donnell, Deborah, Eshleman, Susan H.“…These participants were classified as failing ART; 88 (93.6%) of the non‐seroconverters failing ART had resistance. …”
Publicado 2022
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9por Limbada, Mohammed, Macleod, David, Situmbeko, Vasty, Muhau, Ellen, Shibwela, Osborn, Chiti, Bwalya, Floyd, Sian, Schaap, Albertus J, Hayes, Richard, Fidler, Sarah, Ayles, Helen“…BACKGROUND: Non-facility-based antiretroviral therapy (ART) delivery for people with stable HIV might increase sustainable ART coverage in low-income and middle-income countries. …”
Publicado 2021
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10por Fogel, Jessica M, Zewdie, Kidist, Clarke, William A, Piwowar-Manning, Estelle, Breaud, Autumn, Moore, Ayana, Kosloff, Barry, Shanaube, Kwame, van Zyl, Gert, Scheepers, Michelle, Floyd, Sian, Bock, Peter, Ayles, Helen, Fidler, Sarah, Hayes, Richard, Donnell, Deborah, Eshleman, Susan H“…BACKGROUND: Antiretroviral therapy (ART) reduces human immunodeficiency virus (HIV) transmission risk. …”
Publicado 2022
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11por Bell-Mandla, Nomtha, Wilson, Ethan, Sharma, Deeksha, Sloot, Rosa, Bwalya, Justin, Schaap, Ab, Donnell, Deborah, Piwowar-Manning, Estelle, Floyd, Sian, Makola, Nozizwe, Nkonki, Lungiswa, Simwinga, Musonda, Moore, Ayana, Hayes, Richard, Fidler, Sarah, Ayles, Helen, Bock, Peter“…In this study, we have used an individual-level cohort study design to evaluate the association between sex and other baseline characteristics and participant retention in the HPTN 071 (PopART) trial in Zambia and South Africa. METHODS: HPTN 071 (PopART) was a community randomized trial (CRT) conducted from 2013 to 2018, in 21 communities. …”
Publicado 2023
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12por Shanaube, Kwame, Schaap, Ab, Chaila, Mwate Joseph, Floyd, Sian, Mackworth-Young, Constance, Hoddinott, Graeme, Hayes, Richard, Fidler, Sarah, Ayles, Helen“…OBJECTIVE: To determine the uptake of home-based HIV counselling and testing (HCT) in four communities of the HPTN 071 (PopART) trial in Zambia among adolescents aged 15–19 years and explore factors associated with HCT uptake. …”
Publicado 2017
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13por Eshleman, Susan H, Piwowar‐Manning, Estelle, Wilson, Ethan A, Lennon, Denni, Fogel, Jessica M, Agyei, Yaw, Sullivan, Philip A, Weng, Lei, Moore, Ayana, Laeyendecker, Oliver, Kosloff, Barry, Bwalya, Justin, Maarman, Gerald, van Deventer, Anneen, Floyd, Sian, Bock, Peter, Ayles, Helen, Fidler, Sarah, Hayes, Richard, Donnell, Deborah“…INTRODUCTION: The HPTN 071 (PopART) trial evaluated the impact of an HIV combination prevention package that included “universal testing and treatment” on HIV incidence in 21 communities in Zambia and South Africa during 2013‐2018. …”
Publicado 2020
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14por Shanaube, Kwame, Gachie, Thomas, Hoddinott, Graeme, Schaap, Albertus, Floyd, Sian, Mainga, Tila, Bond, Virginia, Hayes, Richard, Fidler, Sarah, Ayles, Helen“…METHODS: We conducted a cross-sectional survey from August-November 2017 in seven control communities of HPTN 071 (PopART) trial (a community-randomised trial of universal HIV testing and treatment), enrolling approximately 1400 eligible adolescents. …”
Publicado 2022
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15por Shanaube, Kwame, Macleod, David, Chaila, Mwate Joseph, Mackworth-Young, Constance, Hoddinott, Graeme, Schaap, Ab, Floyd, Sian, Bock, Peter, Hayes, Richard, Fidler, Sarah, Ayles, Helen“…PURPOSE: The PopART for Youth (P-ART-Y) study was nested within the HPTN 071 (PopART) trial, a three-arm community randomized trial in 21 communities in Zambia and South Africa. …”
Publicado 2021
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16por Hayes, Richard J., Donnell, Deborah, Floyd, Sian, Mandla, Nomtha, Bwalya, Justin, Sabapathy, Kalpana, Yang, Blia, Phiri, Mwelwa, Schaap, Ab, Eshleman, Susan H., Piwowar-Manning, Estelle, Kosloff, Barry, James, Anelet, Skalland, Timothy, Wilson, Ethan, Emel, Lynda, Macleod, David, Dunbar, Rory, Simwinga, Musonda, Makola, Nozizwe, Bond, Virginia, Hoddinott, Graeme, Moore, Ayana, Griffith, Sam, Sista, Nirupama Deshmane, Vermund, Sten H., El-Sadr, Wafaa, Burns, David N., Hargreaves, James R., Hauck, Katharina, Fraser, Christophe, Shanaube, Kwame, Bock, Peter, Beyers, Nulda, Ayles, Helen, Fidler, Sarah“…METHODS: In this community-randomized trial (2013-18), 21 communities in Zambia and South Africa were randomized to Arm A (PopART intervention, universal antiretroviral therapy [ART]), Arm B (PopART intervention, ART per local guidelines), and Arm C (standard-of-care). …”
Publicado 2019
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17por Bond, Virginia, Hoddinott, Graeme, Viljoen, Lario, Ngwenya, Fredrick, Simuyaba, Melvin, Chiti, Bwalya, Ndubani, Rhoda, Makola, Nozizwe, Donnell, Deborah, Schaap, Ab, Floyd, Sian, Hargreaves, James, Shanaube, Kwame, Fidler, Sarah, Bock, Peter, Ayles, Helen, Hayes, Richard, Simwinga, Musonda, Seeley, Janet“…BACKGROUND: In a cluster-randomised trial (CRT) of combination HIV prevention (HPTN 071 (PopART)) in 12 Zambian communities and nine South African communities, carried out from 2012 to 2018, the intervention arm A that offered HIV treatment irrespective of CD4 count did not have a significant impact on population level HIV incidence. …”
Publicado 2021
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18por Cori, Anne, Ayles, Helen, Beyers, Nulda, Schaap, Ab, Floyd, Sian, Sabapathy, Kalpana, Eaton, Jeffrey W., Hauck, Katharina, Smith, Peter, Griffith, Sam, Moore, Ayana, Donnell, Deborah, Vermund, Sten H., Fidler, Sarah, Hayes, Richard, Fraser, Christophe“…BACKGROUND: The HPTN 052 trial confirmed that antiretroviral therapy (ART) can nearly eliminate HIV transmission from successfully treated HIV-infected individuals within couples. …”
Publicado 2014
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19por Floyd, Sian, Ayles, Helen, Schaap, Albertus, Shanaube, Kwame, MacLeod, David, Phiri, Mwelwa, Griffith, Sam, Bock, Peter, Beyers, Nulda, Fidler, Sarah, Hayes, Richard“…BACKGROUND: HPTN071(PopART) is a 3-arm community-randomised study in 21 peri-urban/urban communities in Zambia and the Western Cape of South Africa, with high HIV prevalence and high mobility especially among young adults. …”
Publicado 2018
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20por Thomas, Ranjeeta, Probert, William J M, Sauter, Rafael, Mwenge, Lawrence, Singh, Surya, Kanema, Sarah, Vanqa, Nosivuyile, Harper, Abigail, Burger, Ronelle, Cori, Anne, Pickles, Michael, Bell-Mandla, Nomtha, Yang, Blia, Bwalya, Justin, Phiri, Mwelwa, Shanaube, Kwame, Floyd, Sian, Donnell, Deborah, Bock, Peter, Ayles, Helen, Fidler, Sarah, Hayes, Richard J, Fraser, Christophe, Hauck, Katharina“…Two intervention scenarios were modelled: annual rounds of PopART from 2014 to 2030 (PopART 2014–30; as the UNAIDS Fast-Track target year) and three rounds of PopART throughout the trial intervention period (PopART 2014–17). …”
Publicado 2021
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