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    “…Sensitivity analysis showed that exclusion of any single study did not influence overall results. [Figure: see text] [Figure: see text] [Figure: see text] CONCLUSION: Females with SAB have higher mortality than males in both unadjusted and adjusted analyses. …”
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    1030. Association of Female Sex with Mortality in Patients with Staphylococcus aureus Bacteremia: a Systematic Review and Meta-analysis
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    “…RESULTS: Compared with planktonic cells, biofilm-dispersed cells in both S. aureus WT and KO backgrounds exhibited: (1) ~10-fold less phagocytosis by BMDMs (p = 0.0003; Figure 1); (2) increased macrophage killing (23% vs. 8%; p = 0.0038; Figure 2); (3) stronger pro- (e.g., IFN-y, IL-2, IL-6, IL-17; Figure 3A) and anti- (e.g., IL-10, IL-4, IL-22; Figure 3B) inflammatory cytokine responses from macrophages (P < 0.05 for all); (4) significantly higher δ toxin PSM production (P = 0.0090; Figure 4) in WT background only. …”
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    2594. Biofilm-Dispersed Staphylococcus aureus Exhibits a Distinct agr-Independent Host Interaction
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    “…A Kaplan-Meier curve of all-cause 30-day mortality is in Figure 2 [Figure: see text] [Figure: see text] Desirability of outcome ranking at 30-days. …”
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    1029. Increased Mortality in Hospital-Onset Carbapenem-Resistant Enterobacterales Bloodstream Infections
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    “…Differential gene expression and gene co-expression analyses were performed (Fig 1). Figure 1 [Figure: see text] Overview of study design. …”
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    240. Transcriptional signatures differentiate pathogen- and treatment-specific host responses in patients with bacterial bloodstream infections
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    “…The changes in the 'major microbiological' and 'imaging' criteria had the most impact (Figure 1). Findings were robust in sensitivity analyses (Table 3). …”
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    963. External Validation of the 2023 Duke - International Society for Cardiovascular Infectious Diseases (ISCVID) Diagnostic Criteria for Infective Endocarditis (IE)
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    “…We simulated therapy guided by RMDs and compared with the observed empiric BLs using a DOOR-MAT score (Figure 1). RESULTS: A total of 36,531 BSI cases were identified. …”
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    1757. Using the Desirability of Outcome Ranking for Management of Antimicrobial Therapy (DOOR-MAT) to Assess Antibiotic Therapy Guided by Rapid Molecular Diagnostics (RMD) in Bloodstream Infection (BSI) Caused by Escherichia coli and Klebsiella pneumoniae
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    “…BLs were grouped into five tiers of increasing spectrum, both with and without a requirement for anaerobic activity (Figure 1). Tiers of BLs across the treatment periods were summarized and compared with the lowest-spectrum tier with an active agent. …”
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    1052. Do Healthcare Providers De-Escalate β-Lactam (BL) Antibiotic Therapy Based on Results of Antibiotic Susceptibility Testing (AST)? Analysis of Bloodstream Infections (BSI) Caused by Escherichia coli and Klebsiella pneumoniae From the Veterans Health Administration (VHA)
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    “…Most other IP related AEs were of mild severity and similar across Cohorts except prolonged prothrombin time (PT) AEs, which was more frequent in combination Cohorts. [Figure: see text] [Figure: see text] CONCLUSION: Clinicians should only consider using CZA-ATM when the benefits outweigh the risks. …”
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    233. Safety of Ceftazidime-Avibactam (CZA) in Combination with Aztreonam (ATM) in a Phase I, Open-Label Study in Healthy Adult Subjects (COMBINE)
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    “…In vitro T cell stimulation assays controlling for HLA genotype are in progress. [Figure: see text] [Figure: see text] CONCLUSION: We provide evidence to suggest that variation in peptide binding and cell surface expression may explain the association of HLA class II haplotypes with S. aureus infection. …”
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    307. Exploring HLA genotypes as contributing risk factors in Staphylococcus aureus bacteremia
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    “…The probability of a better DOOR outcome for a randomly selected MBL was 58% [95% CI: 48.2, 67.4], indicating no significant difference between the groups. [Figure: see text] [Figure: see text] Legend: Infection = categorization as infection or colonization. …”
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    229. Molecular and Clinical Epidemiology of Carbapenemase-Producing E. coli Isolates from Different Global Regions (CRACKLE-2)
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    “…Figure 1 [Figure: see text] Cox proportional hazards model total in-hospital mortality in patients with gram-negative bloodstream infections. …”
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    960. Clinical impact of follow-up blood cultures in gram-negative bloodstream infections: A validation cohort
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    “…Gastrointestinal AEs, mostly mild nausea, were more frequent with BPR, consistent with data from previous Phase 3 studies. [Figure: see text] [Figure: see text] [Figure: see text] CONCLUSION: Ceftobiprole is non-inferior to daptomycin for overall success in patients with complicated SAB. …”
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    LB2302. Ceftobiprole Compared to Daptomycin With or Without Optional Aztreonam for the Treatment of Complicated Staphylococcus aureus (SAB): Results of a Phase 3, Randomized, Double-Blind Trial (ERADICATE)
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    “…These 4 patients all had unsuccessful discharge combined with renal failure (n=2), and/or lack of clinical response (n=3). [Figure: see text] Desirability of outcome ranking (DOOR) analyses [Figure: see text] Shown are the percentages of patients in each group with a specific DOOR category outcome. …”
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    215. Shorter vs. Longer Duration of Treatment in Patients with Ceftriaxone-resistant and Ceftriaxone-susceptible Escherichia coli Bloodstream Infections
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    “…[Figure: see text] BALB/c mice infected with paired initial or relapsed GNB-BSI isolate. 50 mg/kg ertapenem added at 3 hours post infection (hpi). …”
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    224. Clinical Relevance of Antibiotic Tolerance in Recurrent Gram-negative Bloodstream Infections
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    “…Risk factors for GNB-BSI relapse included cardiac device (OR: 3.7 [CI: 1.7-8.3]), and admission to surgical service (OR: 3.7 [CI:1.3-9.4]). Figure 1: Species Breakdown [Image: see text] Proportional comparison of the Gram-negative bacterial species identified in patients with recurrent and non-recurrent bloodstream infections. …”
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    59. Risk Factors for Recurrent Gram-Negative Bacterial Bloodstream Infections
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    “…Collectively, antimicrobial therapy could have changed for 41/223 (18.4%, 95% CI 13.5-24.1) participants if mcfDNA results were available to treating clinicians. [Figure: see text] [Figure: see text] CONCLUSION: Positive plasma mcfDNA sequencing results could have supported changes in clinical management for pneumonia and non-pulmonary infections among immunocompromised patients undergoing bronchoscopy. …”
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    870. Plasma microbial cell-free DNA sequencing impacts antimicrobial management in immunocompromised patients with pneumonia
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    “…VNRX-7145 is currently in development with the oral cephalosporin, ceftibuten (CTB) (Figure 1). [Image: see text] Figure 1. Structures of VNRX-7145, VNRX-5236, and ceftibuten. …”
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    1055. ARGONAUT-IV: Susceptibility of Carbapenem-resistant Klebsiellae to Ceftibuten/VNRX-5236
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    “…C. difficile exhibited substantial diversity: 47 distinct ribotypes were observed among 70 isolates (Figure 1). Fourteen clusters involving identical strain types were observed, totaling 35 isolates. …”
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    498. Molecular Epidemiology of C. difficile Within a Community Hospital: A Pilot for a Regional Survey
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    “…Component analyses in two trials showed that the study treatment was nominally statistically inferior to the comparator with regard to SAEs and clinical failure, respectively (Fig. 1b, 1c). [Figure: see text] [Figure: see text] Trial 1 has no significant differences between the treatment arms in the component analysis (A). …”
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    223. Development and Analysis of a Novel DOOR Endpoint for Complicated Intra-abdominal Infections (cIAI) Using 10 Registrational Trials for Antibacterial Drugs
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    “…RESULTS: Of 36,531 BSI identified, we analyzed a subset of 21,597 that met our inclusion criteria (figure). Within this subset of patients, the mean age was 70.3 and all-cause 30-day mortality was 13.9% (2,054 out of 14,735) for E. coli and 17.8% (1,220 out of 6,862) for K. pneumoniae. …”
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    1041. How Do Healthcare Providers Approach Empiric β-Lactam (BL) Treatment of Bloodstream Infections (BSI) Caused by Gram-Negative Rods (GNRs)? Analysis of Escherichia coli and Klebsiella pneumoniae BSI From the Veterans Health Administration (VHA)
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