Mostrando 1 - 20 Resultados de 23 Para Buscar 'POPULATION DYNAMICS', tiempo de consulta: 0.37s Limitar resultados
  1. 1
    “…Fitting a multilocus NFDS model of post-vaccine population dynamics to three genomic datasets using Approximate Bayesian Computation generated reproducible estimates of the influence of NFDS on pneumococcal evolution, the strength of which varied between loci. …”
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    Frequency-dependent selection in vaccine-associated pneumococcal population dynamics
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    “…Previous work on bacteriocin dynamics has highlighted the role of non-transitive ‘rock–paper–scissors’ competition in maintaining the coexistence of different bacteriocin profiles. …”
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    Epidemiological dynamics of bacteriocin competition and antibiotic resistance
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    Essential epidemiological mechanisms underpinning the transmission dynamics of seasonal influenza
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    “…This approach allows use to examine the direct effects of network structure on pathogen phylogenies, largely controlling for confounding differences arising from population dynamics. We find that networks with more heterogeneous degree distributions yield pathogen phylogenies with more variable cluster numbers, smaller mean cluster sizes, shorter mean branch lengths, and somewhat higher tree imbalance than networks with relatively homogeneous degree distributions. …”
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    How the Dynamics and Structure of Sexual Contact Networks Shape Pathogen Phylogenies
  5. 5
    “…In this state, the whole body’s viral population is stable over time, but the equilibrium results from an underlying, highly dynamic process of local infection and clearance within T-cell centers. …”
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    Large Variations in HIV-1 Viral Load Explained by Shifting-Mosaic Metapopulation Dynamics
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    “…This same phenomenon explains why serotypes with longer durations of carriage tend to be more resistant. These dynamics may apply to other potentially pathogenic, microbial commensals and highlight how population structure, which is often omitted from models, can have a large impact.…”
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    Host population structure and treatment frequency maintain balancing selection on drug resistance
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    “…This result suggests that targeted interventions to these hotspots will not alone control the epidemic in inland populations, where most transmissions occur. Thus, geographical targeting of high prevalence areas might not be effective for broader epidemic control depending on underlying epidemic dynamics. …”
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    Quantifying HIV transmission flow between high-prevalence hotspots and surrounding communities: a population-based study in Rakai, Uganda
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    “…Only one pair involved a WHR and male participant, suggesting that improved population sampling is needed to assess empirically the role of WHR to the transmission dynamics. …”
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    Phylogenetic and Demographic Characterization of Directed HIV-1 Transmission Using Deep Sequences from High-Risk and General Population Cohorts/Groups in Uganda
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    “…Using sequence data to infer population dynamics is playing an increasing role in the analysis of outbreaks. …”
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    Inferring pandemic growth rates from sequence data
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    “…Here we describe a novel method that combines epidemiological and population genetic approaches to estimate the variation in transmissibility of rapidly-evolving viral epidemics. …”
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    Integrating Phylodynamics and Epidemiology to Estimate Transmission Diversity in Viral Epidemics
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    “…To understand the transmission dynamics and potential impact of an outbreak, several types of data are necessary. …”
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    Key data for outbreak evaluation: building on the Ebola experience
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    “…If viral reproduction rates increase significantly during the course of infection, the viral population will evolve a high level of virulence even though this will reduce the transmission potential of the virus. …”
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    IS HIV SHORT-SIGHTED? INSIGHTS FROM A MULTISTRAIN NESTED MODEL
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    “…We conclude that while treatment and contact heterogeneity can promote coexistence to some extent, the in-host interactions between strains, particularly the interplay between coinfection, multiple infection and immunity, play a crucial role in the long-term population dynamics of pathogens with drug resistance.…”
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    What is the mechanism for persistent coexistence of drug-susceptible and drug-resistant strains of Streptococcus pneumoniae?
  14. 14
    “…CONCLUSIONS: Our findings suggest that population mobility patterns are fundamental to HIV transmission dynamics and to the impact of HIV control strategies. …”
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    Deep-sequence phylogenetics to quantify patterns of HIV transmission in the context of a universal testing and treatment trial – BCPP/Ya Tsie trial
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    “…We developed a mathematical model to simulate the dynamics of putative viral genotypes that differ in their virulence. …”
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    Transmission Selects for HIV-1 Strains of Intermediate Virulence: A Modelling Approach
  16. 16
    “…However, the concomitant incidence dynamics result in a very large reproductive number and are not consistent with empirical estimates of H3N2's population level attack rate. …”
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    Phylodynamic Inference and Model Assessment with Approximate Bayesian Computation: Influenza as a Case Study
  17. 17
    “…Seasonal fluctuations in antibiotic usage translate into small fluctuations of the frequency of resistance around the average value. We describe these dynamics using a perturbation approach that encapsulates all ecological and evolutionary forces into a generic model, whose parameters quantify a force stabilizing the frequency of resistance around the equilibrium and the sensitivity of the population to antibiotic selection. …”
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    An evolutionary model to predict the frequency of antibiotic resistance under seasonal antibiotic use, and an application to Streptococcus pneumoniae
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    “…We assess the impact and cost-effectiveness of introducing POC CD4 testing at the population level in South Africa in a range of care contexts, using a dynamic compartmental model of HIV transmission, calibrated to the South African HIV epidemic. …”
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    Impact and Cost-Effectiveness of Point-Of-Care CD4 Testing on the HIV Epidemic in South Africa
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    “…Viral phylogenetic methods contribute to understanding how HIV spreads in populations, and thereby help guide the design of prevention interventions. …”
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    Phylogenetic Tools for Generalized HIV-1 Epidemics: Findings from the PANGEA-HIV Methods Comparison
  20. 20
    “…A key feature of OpenABM-Covid19 are its Python and R interfaces, which has allowed scientists and policymakers to simulate dynamic packages of interventions and help compare options to suppress the COVID-19 epidemic.…”
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    OpenABM-Covid19—An agent-based model for non-pharmaceutical interventions against COVID-19 including contact tracing
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